Protein Alignment IA-2 and Ptprj

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_038960584.1
• Gene: Ptprj / 29645
• RGDID: 3454
• Length: 1352
• Species: Rattus norvegicus
• Alignment Length: 905
• Identity: 202/905 - (22%)
• Similarity: 338/905 - (37%)
• Gaps: 223/905 - (24%)

  Fly   460 NESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFREL--AGEQGLVQEPPLRFRHVETE 522
            :||.|::.....:  ::....|.|.|:..||:.:|..|:..|:  .|..|  .|.|.:.....|:
  Rat   495 SESFEIFITQEGS--EKRWNASTGDLSYIVENLKPGTSYQFEIFPRGPNG--TEGPSQTVVGRTD 555

  Fly   523 VDATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVY 587
            ..|..::   |..|   :...::.|:.|.....||...: |....|...:.:||      ||:..
  Rat   556 CSAVTDI---RVVS---VSTTEIQLEWQNTDSASGYTYH-LVLESENGSIKTNS------SQKWI 607

  Fly   588 TEGGL--------LLMPQDEQ----DTDGMQADEPENVK--QSLLANMLGFARHERLDVKKPGPL 638
            |.|||        .:.|:.:|    .:...|...|.||.  :......:...:.:.||.
  Rat   608 TVGGLTPGTLYNVTIFPEVDQMEGNSSSITQYTRPSNVSYIEVNTNTTVAAIQWKNLDA------ 666

  Fly   639 LGPPSLGSAELSNQLETEKAHKQKGHGN------KEVLPAHIKGNDEDDAHKKKKVMKQQHSAED 697
                  .||..|..:...||    |.|:      :::....|.|.....:::.|...|.:::...
  Rat   667 ------ASASYSYSVLILKA----GDGSNVTSRVRDIPSVTIPGLIPGVSYEVKIFTKIRNTEVG 721

  Fly   698 H----------APHTVDTEYVHVFVKNPI---------------------DSWNDGQRIMKELE- 730
            :          .|..||:.:..|..|.|.                     |:|::    |..||
  Rat   722 NEVPGQKLFCMEPAQVDSLHCEVVPKEPALVLKWACPPGMNSGFELGVRSDAWDN----MTHLEN 782

  Fly   731 -----------QILHMQGYFSY----LTVQQHEVSFRVNS------NNPERKTAGDVARTINENR 774
                       ::.::....||    .|:...:::....|      .:|..........:::.|
  Rat   783 CTLDNDTECRTEVTYLNFSTSYNISIATLSCGKMALPTQSTCTTGITDPPPPDGSPNITSVSHN- 846

  Fly   775 GVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAG--AGAAAVIV 837
            .||....   ||...|..:          ...:..:...|.|...|.::.|.:..  .||:...|
  Rat   847 SVKVKFS---GFEASHGPI----------KAYAVLLTTGEAGQPSTDVLKYTYEDFKKGASDTYV 898

  Fly   838 IFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEP 902
            .:    ||:..::      |...|::.|.....|.              |..||......|..||
  Rat   899 TY----LIRIEEK------GQSQGLSEALNYEIDV--------------GNQSTTLGYYNGRLEP 939

  Fly   903 APSGR-----ITSL--SKENEG--RPPSSRSSTSSWSEEPAL----------------------- 935
            ..|.|     .|::  :.:|:|  ....|..|.|.:||..:|
  Rat   940 LGSYRACVAGFTNITYNLQNDGLINGDESYVSFSPYSEAVSLPQDPGVICGAVFGCIFGALAIVA 1004

  Fly   936 ---------TNMDISTGHMVLSYMEDHLRNKGRLQR--EWEALCRYEAEPS----ARE------- 978
                     ...|.....:..|.::.   .|.:|.|  .:||..:.:...|    |.|
  Rat  1005 VGGFIFWRKKRKDAKNNEVSFSQIKP---KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLI 1066

  Fly   979 -------AASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQG 1036
                   ||...:..|.||....||||.|||.|:...::.. ||:||:.:..:..:.. ::|.||
  Rat  1067 GISLPKYAAEIAENRGKNRYNNVLPYDISRVKLSVQTHSTD-DYINANYMPGYHSKKD-FIATQG 1129

  Fly  1037 PLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYL 1101
            |||:||..||:|:||:....||.|.:..|.|...|..|||.:.|:.|....|.:.|| :...::.
  Rat  1130 PLPNTLKDFWRMVWEKNVYAIVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSE-VVLPEWT 1193

  Fly  1102 VRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR--RSCPIVVHGSAG 1164
            :|.|.:||:::||:..:.||||.|||..|||.....|::||..| :.|..:  ...||:||.|||
  Rat  1194 IRDFVVKNMQSSESHPLRQFHFTSWPDHGVPDTTDLLINFRYLV-RDYMKQIPPESPILVHCSAG 1257

  Fly  1165 AGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA 1224
            .||||.:|.:|.::.:: :....:|:...:..||..|..:|.|..|:.|:...|.:.:.|
  Rat  1258 VGRTGTFIAIDRLIYQI-ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRA 1316

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	19/132 (14%)
		PTP_DSP_cys	942..1225	CDD:475123	97/305 (32%)
Ptprj	XP_038960584.1	FN3	169..659	CDD:442628	39/180 (22%)
		fn3	642..719	CDD:394996	16/92 (17%)
		PTP_tm	850..980	CDD:465889	32/166 (19%)
		R-PTPc-J	1084..1312	CDD:350463	84/232 (36%)