Protein Alignment IA-2 and Ptpn22

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001099930.1
• Gene: Ptpn22 / 295338
• RGDID: 1307992
• Length: 804
• Species: Rattus norvegicus
• Alignment Length: 364
• Identity: 113/364 - (31%)
• Similarity: 165/364 - (45%)
• Gaps: 48/364 - (13%)

  Fly   969 RYEAE---PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITD-HDPRAP 1029
            :|:|:   |:.  .|.:|:....||....||||||.|.|:.|.:.|...|:|||.|.. :.||
  Rat    37 KYKADKIYPTT--VAQRPKNIKKNRYKDILPYDHSLVELSLLTSDEDSSYINASFIKGVYGPR-- 97

  Fly  1030 AYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEH 1094
            ||:|.||||.:||..||:||||...:|||..|...|.|:..|.|||.|.|..     ::......
  Rat    98 AYIATQGPLSTTLLDFWRMIWEYRVLVIVMACMEFEMGKKKCERYWAEPGET-----QLQFGPFS 157

  Fly  1095 IWCD------DYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALL----DFRRKVNKSY 1149
            |.|:      ||.:|:  ||....||||.|.|||:.:||...||:....:|    |.|     .|
  Rat   158 ISCETEKKKSDYKIRT--LKAKFNSETRIVYQFHYKNWPDHDVPSSIDPILQLIWDMR-----CY 215

  Fly  1150 RGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKG--AREIDIAATLEHLRDQRAGVVATRQQFE 1212
            :.....|:.:|.|||.|||||...:|.....:..|  .:...:...::.:|.||..:|.|::|:|
  Rat   216 QEDDCVPLCIHCSAGCGRTGVICAVDYTWMLLKDGIIPKNFSVFNLIQEMRTQRPSLVQTQEQYE 280

  Fly  1213 FVLMAVAEEVHAILKALPANTSGEKRELDKDPVVGGGSSSTTTKEPLKEDKAQEAAEEEAPTSSS 1277
            .|..||.|.....:..:..|  ..:||:..:.             .:.|.|....|:........
  Rat   281 LVYSAVLELFKRHVDIISDN--HREREIQAEC-------------SIPEQKLTIEADSYPLDFPK 330

  Fly  1278 KAAAAAKKEKEKDKDKEEKQAKDQAKVAEPRTPAKSAKQ 1316
            .|...||...::.|...|.::.:.:... .||...|||:
  Rat   331 NAVRDAKMTNQQSKQGAEAESTEVSSFG-LRTSKISAKE 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293
		PTP_DSP_cys	942..1225	CDD:475123	97/271 (36%)
Ptpn22	NP_001099930.1	PTPc-N22	57..290	CDD:350450	92/246 (37%)
		Herpes_BLLF1	<539..800	CDD:282904