Protein Alignment IA-2 and Ptpn9

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001013058.1
• Gene: Ptpn9 / 266611
• RGDID: 628726
• Length: 593
• Species: Rattus norvegicus
• Alignment Length: 579
• Identity: 139/579 - (24%)
• Similarity: 236/579 - (40%)
• Gaps: 124/579 - (21%)

  Fly   718 SWNDGQRIM--KELEQILHMQGYFSY---------LTVQQHEVSFR----------VNSNNPERK 761
            |||...:.:  ::.:.:..::.:..|         :.::.||...|          :|..:|
  Rat    43 SWNVAVKFLMARKFDVLRAVELFHCYRETRRKEGIVKLKPHEEPLRSEILSGKFTILNVRDP--- 104

  Fly   762 TAGDV----ARTINENRGVKNNIQRRVGFYVLHAGVGD---------VIKDLQDPSVSSSRIELA 813
            |...:    ||..:.::.|::.:.:.: ||:|...|..         .|.|:...:.::..::|
  Rat   105 TGASIALFTARLHHPHKSVQHVVLQAL-FYLLDRAVDSFETQRNGLVFIYDMCGSNYANFELDL- 167

  Fly   814 EQGPDVTHIMAYMFAG-------AGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKD 871
              |..|.:::...|..       .||.....:..::|.:...|:.|:::..|::        |:.
  Rat   168 --GKKVLNLLKGAFPARLKKVLIVGAPIWFRVPYSIISLLLKDKVRERIQILKT--------SEV 222

  Fly   872 YQELCRARMAGKAGG-----------------GGNSTGGAAGGGSNEPAPSGRITSLSKENEGRP 919
            .|.|.|..:....||                 .|:            |.|...|...|     .|
  Rat   223 TQHLPRECLPENLGGYIKIDLATWNFQFLPQVNGH------------PDPFDEIILFS-----LP 270

  Fly   920 PSSRSSTSSWSEEPALTNMDISTGH-MVLSYMEDHL--RNKGRLQREWEALCRYEAEPSAREAAS 981
            |:     ..|.      ::.:...| |.:..:.|::  |.|..:..|:|.: |.|........:.
  Rat   271 PA-----LDWD------SVHVPGPHAMTIQELVDYVNTRQKQGIYEEYEDI-RRENPVGTFHCSM 323

  Fly   982 QPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFW 1046
            .|.....||.|.....|.:||.|...:.....||:||| ..|...:..||:..||||.:|...||
  Rat   324 SPGNLEKNRYGDVPCLDQTRVKLTKRSGHTQTDYINAS-FMDGYKQKNAYIGTQGPLENTYRDFW 387

  Fly  1047 QMIWEQGAVVIVALCRLQENGEVACARYWP-EEGAEVY--HIYEVHLVSEHIWCDDYLVRSFYLK 1108
            .|:|||..:|||...|.:|.|...|.:||| |:.:.:.  .:...:|..|::  :.|...:..:.
  Rat   388 LMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLEKDSRIQFGFLTVTNLGVENM--NHYKKTTLEIH 450

  Fly  1109 NLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSY---------RGRRSC---PIVVHG 1161
            |....:.|.||.|.|||||..|||:.|.:|:||.|.|....         |.:..|   |||||.
  Rat   451 NTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRSQQSMAVGSLGARSKGQCPEPPIVVHC 515

  Fly  1162 SAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE 1220
            |||.||||.:..||:.|.::.: ...:::..|:..:|.|||..:.|.:|:.|...|:.|
  Rat   516 SAGIGRTGTFCSLDICLAQLEE-LGTLNVFQTVSRMRTQRAFSIQTPEQYYFCYKAILE 573

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	17/101 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	96/297 (32%)
Ptpn9	NP_001013058.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..21
		CRAL_TRIO_N	20..66	CDD:215024	3/22 (14%)
		SEC14	90..238	CDD:214706	27/162 (17%)
		PTPc-N9	299..569	CDD:350391	90/274 (33%)