DRSC/TRiP Functional Genomics Resources

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Protein Alignment IA-2 and Ptprs

DIOPT Version :10

Sequence 1:NP_608562.4 Gene:IA-2 / 33277 FlyBaseID:FBgn0031294 Length:1319 Species:Drosophila melanogaster
Sequence 2:XP_038938986.1 Gene:Ptprs / 25529 RGDID:3452 Length:1916 Species:Rattus norvegicus


Alignment Length:1287 Identity:283/1287 - (21%)
Similarity:450/1287 - (34%) Gaps:423/1287 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 DLAQAEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEEL 232
            :|...||:.|.:..||         :|        |||...|||::  |.||...|:.|...:  
  Rat   544 ELLFREGDRGREVGRT---------FD--------PTTAFVVEDLK--PNTEYAFRLAARSPQ-- 587

  Fly   233 QGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPN--LCANL---------APTPPEFGDPASALAYV 286
               |||.....|:.|      :||.:...||.  .|.:|         .|.|||..:.|.....|
  Rat   588 ---GLGAFTAVVRQR------TLQAKPSAPPQDVKCTSLRSTAILVSWRPPPPETHNGALVGYSV 643

  Fly   287 RFTP-----PEPE-------------------------AELDYYEQPAGPA---------QFYPA 312
            |:.|     |:|:                         ..:.|.|...||.         :..|:
  Rat   644 RYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDVPS 708

  Fly   313 LRKKQVRESDADDMYLNRMLQDRRRLRHDPSELE----HFGKMDGHGQSTQLDAPSIMDAFLDTE 373
            ...::| |::|.:....|:|...........::.    |:.:|:|   :.....|.|.|.     
  Rat   709 APPRKV-EAEALNATAIRVLWRSPTPGRQHGQIRGYQVHYVRMEG---AEARGPPRIKDI----- 764

  Fly   374 RQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRKPAA----------QPNAMDQ 428
                    .||.|:.:.|..||      |:::..:......|....||          :|..:..
  Rat   765 --------MLADAQWEMDDTAE------YEMVITNLQPETAYSITVAAYTMKGDGARSKPKVVVT 815

  Fly   429 LEAI-------VEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNF--------------- 471
            ..|:       |:|..:..|..:.|        ||.:..|...|.:...|               
  Rat   816 KGAVLGRPTLSVQQTPEGSLLARWE--------PPADAAEDPVLGYRLQFGREDAAPATLELAAW 872

  Fly   472 -----APFK-------RARGRSRGGLAEE------VEDEQPKRSFFRELAGEQGLVQE------- 511
                 ||..       |...|.|.||.||      :.::.|:.  |.::.|..|.|..       
  Rat   873 ERRFAAPAHKGATYVFRLAARGRAGLGEEASAALSIPEDAPRG--FPQILGAAGNVSAGSVILRW 935

  Fly   512 -PPLRFRH--------------------VETEVDATPE--------LVKRRPASFKQL------- 540
             ||:....                    .|||:.|..:        |...||.:..:|       
  Rat   936 LPPVPAERNGAIIKYTVSVREAGAPGPATETELAAAAQPGAETALTLQGLRPETAYELRVRAHTR 1000

  Fly   541 ---DPYDVSLQQQEMAFESGLLRNSLTP-------LEEEAMLASNSFPRQAKSQRVY--TEGGLL 593
               .|:...|:.:       |.|:.::|       :.:.::|.|..||....|...|  ...||.
  Rat  1001 RGPGPFSPPLRYR-------LARDPVSPKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLT 1058

  Fly   594 LMPQDEQDTDGMQAD------EPENVKQSLLANMLGFARHERLDVKKPGPLLGPPSLGSAELSNQ 652
            |      |.||....      :|......:|.|.                   ..|||..:   |
  Rat  1059 L------DVDGRTTKKLITHLKPHTFYNFVLTNR-------------------GSSLGGLQ---Q 1095

  Fly   653 LETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYV--------- 708
            ..|.:.......|...|.|.    .|.|.:       ...:..:..:|.||...::         
  Rat  1096 TVTARTAFNMLSGKPSVAPK----PDNDGS-------IVVYLPDGQSPVTVQNYFIVMVPLRKSR 1149

  Fly   709 ----HVFVKNPIDSWNDGQRIMKELEQIL---------------HMQGYFSYLTVQQHEVSFRVN 754
                .:.:.:|.|.  |.:.::::|.::.               ::...||.|....|.      
  Rat  1150 GGQFPILLGSPEDM--DLEELIQDLSRLQRRSLRHSRQLEVPRPYIAARFSILPAVFHP------ 1206

  Fly   755 SNNPERKTAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQ--DPSVSSSRIELAEQ-- 815
               ..:|..|..     :|||::...:     |||.     |:..||  :|:.::|......|  
  Rat  1207 ---GNQKQYGGF-----DNRGLEPGHR-----YVLF-----VLAVLQKNEPTFAASPFSDPFQLD 1253

  Fly   816 GPD--------------VTHIMAYMFAGAGAAAVIVIFVTLILIK-RHDRKRDKLGGLQSGIAGA 865
            .||              :..::|.:|       :|.|.:.::|.| :.|.||             
  Rat  1254 NPDPQPIVDGEEGLIWVIGPVLAVVF-------IICIVIAILLYKNKPDSKR------------- 1298

  Fly   866 ETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWS 930
                ||.:...:..:         :....|.....:|....||...:......||.         
  Rat  1299 ----KDSEPRTKCLL---------NNADLAPHHPKDPVEMRRINFQTPGMLSHPPI--------- 1341

  Fly   931 EEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEAL---CRYEAEPSAREAASQPQCAGLNRPG 992
               .:|:|   ..||......|.|    :|.:|:|::   .::..|.|..| |::|:    ||..
  Rat  1342 ---PITDM---AEHMERLKANDSL----KLSQEYESIDPGQQFTWEHSNLE-ANKPK----NRYA 1391

  Fly   993 APLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVI 1057
            ..:.||||||:|..|....|.||:||:.: |...|..||:|.|||||.|...||:|:|||.:..:
  Rat  1392 NVIAYDHSRVILQPLEGIMGSDYINANYV-DGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATV 1455

  Fly  1058 VALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFH 1122
            |.:.||:|...|.|.:|||..|.|.|...:|.|: :.:....:.||:|.|....:||.|.|..|.
  Rat  1456 VMMTRLEEKSRVKCDQYWPNRGTETYGFIQVTLL-DTMELATFCVRTFSLHKNGSSEKREVRHFQ 1519

  Fly  1123 FLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSC------PIVVHGSAGAGRTGVYILLDLVLERM 1181
            |.:||..|||......|.|.|:|       ::|      |:|||.|||.||||.:|::|.:|||:
  Rat  1520 FTAWPDHGVPEYPTPFLAFLRRV-------KTCNPPDAGPVVVHCSAGVGRTGCFIVIDAMLERI 1577

  Fly  1182 NKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANT 1233
             :..:.:|:...:..:|.||..:|.|..|:.|:..|:.|.|......:||.:
  Rat  1578 -RTEKTVDVYGHVTLMRSQRNYMVQTEDQYSFIHEALLEAVGCGNTEVPARS 1628

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IA-2NP_608562.4 Receptor_IA-2 705..795 CDD:463293 16/117 (14%)
PTP_DSP_cys 942..1225 CDD:475123 105/291 (36%)
PtprsXP_038938986.1 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409570
Ig strand C 63..67 CDD:409570
Ig strand E 86..93 CDD:409570
Ig strand F 104..109 CDD:409570
Ig strand G 117..120 CDD:409570
IgI_2_RPTP_IIa_LAR_like 137..226 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 190..195 CDD:409400
Ig strand F 204..211 CDD:409400
Ig strand G 214..225 CDD:409400
IgI_3_RPTP_IIa_LAR_like 235..316 CDD:409401
Ig strand A 235..237 CDD:409401
Ig strand A' 241..245 CDD:409401
Ig strand B 248..256 CDD:409401
Ig strand C 261..267 CDD:409401
Ig strand C' 269..271 CDD:409401
Ig strand D 274..278 CDD:409401
Ig strand E 283..288 CDD:409401
Ig strand F 295..302 CDD:409401
Ig strand G 306..315 CDD:409401
FN3 309..>711 CDD:442628 44/196 (22%)
FN3 710..815 CDD:238020 22/127 (17%)
FN3 823..899 CDD:214495 15/83 (18%)
FN3 925..1013 CDD:238020 13/87 (15%)
FN3 1018..1101 CDD:238020 21/110 (19%)
R-PTPc-S-1 1338..1619 CDD:350473 109/314 (35%)
R-PTP-S-2 1621..1910 CDD:350475 2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

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