Protein Alignment IA-2 and Ptprt

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_017172075.1
• Gene: Ptprt / 19281
• MGIID: 1321152
• Length: 1487
• Species: Mus musculus
• Alignment Length: 886
• Identity: 215/886 - (24%)
• Similarity: 329/886 - (37%)
• Gaps: 227/886 - (25%)

  Fly   436 QQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRAR---------GRSRG-GLAEEVE 490
            |.|....:||.:|        |||.::|..|......||...|         ||... .|..:.|
Mouse   429 QYQYVFNQQQYEA--------EEVIQTSSHYTLRGLRPFMTIRLRLLLSNPEGRMESEELVVQTE 485

  Fly   491 DEQPKRSFFRELAG----EQGLVQ-EPPLRFRHVET----------EVDATPELVKRRPASFKQL 540
            ::.|.......:.|    |:..:| :||.....|.|          .:|.:.:|..:|...||
Mouse   486 EDVPGAVPLESIQGGPFEEKIYIQWKPPNETNGVITLYEINYKAVGSLDPSADLSSQRGKVFK-- 548

  Fly   541 DPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGM 605
                  |:.:......||...:......:|..|....|  ..:.|:.|:.....||:.:.||
Mouse   549 ------LRNETHHLFVGLYPGTTYSFTIKASTAKGFGP--PVTTRIATKISAPSMPEYDADT--- 602

  Fly   606 QADEPENVKQSLLANMLGFARHERLDVKKPGPLLGPPSLGSAELS-NQLETEKAHKQKGHGNKEV 669
                |.|...:.:..||           ||....|.|      :| .||..::...||.....::
Mouse   603 ----PLNETDTTITVML-----------KPAQSRGAP------VSVYQLVVKEERLQKSRRAADI 646

  Fly   670 LP------AHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTV-DTEYVHVFVKNPIDSWNDGQRIMK 727
            :.      ::...::.|..|.....:|..:..... |.|| |.:..:.:       ||      .
Mouse   647 IECFSVPVSYRNASNLDSLHYFAAELKPSNLPVTQ-PFTVGDNKTYNGY-------WN------P 697

  Fly   728 ELEQILHMQGYFSYLTVQQHEVSF---RVNSNNP---ERKTAGDVARTINENRGVKNNIQRRVGF 786
            .|..:.....||..|:....|...   |:.:..|   .:.|.|.....:......:|
Mouse   698 PLSPLKSYSIYFQALSKANGETKINCVRLATKAPMGSAQVTPGTPLCLLTTGASTQN-------- 754

  Fly   787 YVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHD-- 849
                                |:.:| .|:..|.|..||.:.||.....:|::.|.|.:.:|.:
Mouse   755 --------------------SNTVE-PEKQVDNTVKMAGVIAGLLMFIIILLGVMLTIKRRRNAY 798

  Fly   850 -------------RKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNE 901
                         ::::...|.|..:....:..|.         ..|.|...|..|
Mouse   799 SYSYYLSQRKLAKKQKETQSGAQREMGPVASTDKP---------TAKLGTNRNDEG--------- 845

  Fly   902 PAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGH-------MVLSYMED------- 952
                  .:|.|::..|....||...|    :|.||   |.| |       :.:||..|
Mouse   846 ------FSSSSQDVNGFTDGSRGELS----QPTLT---IQT-HPYRTCDPVEMSYPRDQFQPAIR 896

  Fly   953 ------HLRNKGR-----LQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNH 1006
                  |:....|     .:.|:|||  .|.:.::.:.|.:.:....||.|..:.||||||.|..
Mouse   897 VADLLQHITQMKRGQGYGFKEEYEAL--PEGQTASWDTAKEDENRNKNRYGNIISYDHSRVRLLV 959

  Fly  1007 LANAEGLDYVNASTITD-HDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGE-- 1068
            |......||:||:.|.. |.||  .|:|.|||:..|:..||:|||::.:..||.:..|.|.|.
Mouse   960 LDGDPHSDYINANYIDGYHRPR--HYIATQGPMQETVKDFWRMIWQENSASIVMVTNLVEVGRHP 1022

  Fly  1069 ------------------VACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSET 1115
                              |.|.||||:: .|||...:|.|:...... :|::|:|.::.....|.
Mouse  1023 AEHTVGTATLGRAASPGMVKCVRYWPDD-TEVYGDIKVTLIETEPLA-EYVIRTFTVQKKGYHEI 1085

  Fly  1116 RTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLER 1180
            |.:..|||.|||..|||..|..||.|.|:| |......:.|||||.||||||||.:|.:|.:|:.
Mouse  1086 RELRLFHFTSWPDHGVPCYATGLLGFVRQV-KFLNPPEAGPIVVHCSAGAGRTGCFIAIDTMLDM 1149

  Fly  1181 M-NKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE 1220
            . |:|.  :||...:..||.||..:|.|.:|:.||..|:.|
Mouse  1150 AENEGV--VDIFNCVRELRAQRVNLVQTEEQYVFVHDAILE 1188

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	12/95 (13%)
		PTP_DSP_cys	942..1225	CDD:475123	111/326 (34%)
Ptprt	XP_017172075.1	MAM	36..193	CDD:214533
		Ig	200..285	CDD:472250
		fn3	298..364	CDD:394996
		FN3	394..484	CDD:238020	16/62 (26%)
		fn3	506..581	CDD:394996	16/84 (19%)
		R-PTPc-T-1	936..1192	CDD:350478	98/260 (38%)
		R-PTPc-T-2	1277..1482	CDD:350482