DRSC/TRiP Functional Genomics Resources

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Protein Alignment IA-2 and Ptprs

DIOPT Version :10

Sequence 1:NP_608562.4 Gene:IA-2 / 33277 FlyBaseID:FBgn0031294 Length:1319 Species:Drosophila melanogaster
Sequence 2:NP_035348.2 Gene:Ptprs / 19280 MGIID:97815 Length:1907 Species:Mus musculus


Alignment Length:1283 Identity:291/1283 - (22%)
Similarity:449/1283 - (34%) Gaps:424/1283 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   168 DLAQAEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATMLEEL 232
            :|...||:.|.:..||         :|        |||...|||::  |.||...|:.|...:  
Mouse   544 ELLFREGDRGREVGRT---------FD--------PTTAFVVEDLK--PNTEYAFRLAARSPQ-- 587

  Fly   233 QGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPN--LCANL---------APTPPEFGDPASALAYV 286
               |||.....|:.|      :||.:...||.  .|.:|         .|.|||..:.|.....|
Mouse   588 ---GLGAFTAVVRQR------TLQAKPSAPPQDVKCTSLRSTAILVSWRPPPPETHNGALVGYSV 643

  Fly   287 RFTP-----PEPE-------------------------AELDYYEQPAGPA---------QFYPA 312
            |:.|     |:|:                         ..:.|.|...||.         :..|:
Mouse   644 RYRPLGSEDPDPKEVNNIPPTTTQILLEALEKWTEYRVTAVAYTEVGPGPESSPVVVRTDEDVPS 708

  Fly   313 LRKKQVRESDADDMYLNRMLQDRRRLRHDPSELE----HFGKMDGHGQSTQLDAPSIMDAFLDTE 373
            ...::| |::|.:....|:|...........::.    |:.:|:|   :.....|.|.|..|...
Mouse   709 APPRKV-EAEALNATAIRVLWRSPTPGRQHGQIRGYQVHYVRMEG---AEARGPPRIKDIMLADA 769

  Fly   374 RQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRK---PAAQPNAMDQLEAI--- 432
            ::.:....|...|               |.|..|:      |..|   ..::|..:....|:   
Mouse   770 QEMVITNLQPETA---------------YSITVAA------YTMKGDGARSKPKVVVTKGAVLGR 813

  Fly   433 ----VEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNF--------------------AP 473
                |:|..:..|..:.|        ||.:..|...|.:...|                    ||
Mouse   814 PTLSVQQTPEGSLLARWE--------PPADAAEDPVLGYRLQFGREDAAPATLELAAWERRFAAP 870

  Fly   474 FK-------RARGRSRGGLAEE------VEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDA 525
            ..       |...|.|.||.||      :.::.|:.  |.::.|..|.|....:..|.:      
Mouse   871 AHKGATYVFRLAARGRAGLGEEAAAALSIPEDAPRG--FPQILGAAGNVSAGSVLLRWL------ 927

  Fly   526 TPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEG 590
            .|...:|..|..|    |.||::      |:|    :..|..|..:.|:    .|..::...|..
Mouse   928 PPVPAERNGAIIK----YTVSVR------EAG----APGPATETELAAA----AQPGAETALTLR 974

  Fly   591 GLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLLGPPSLGSAELSNQLET 655
            ||                .||.      |..|....|.|   :.||| ..||.  ...|:....:
Mouse   975 GL----------------RPET------AYELRVRAHTR---RGPGP-FSPPL--RYRLARDPVS 1011

  Fly   656 EKAHKQKGHGNKEVL-------------PAHIKGN----DEDDAHKKKKVMKQQHSAEDHAPHTV 703
            .|..|.|......||             |..|:.|    |.|....||.:...:       ||| 
Mouse  1012 PKNFKVKMIMKTSVLLSWEFPDNYNSPTPYKIQYNGLTLDVDGRTTKKLITHLK-------PHT- 1068

  Fly   704 DTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYL-------------------------- 742
                .:.||..     |.|.. :..|:|.:..:..|:.|                          
Mouse  1069 ----FYNFVLT-----NRGSS-LGGLQQTVTARTAFNMLSGKPSVAPKPDNDGFIVVYLPDGQSP 1123

  Fly   743 -TVQQHEV-----------SFRVNSNNPERKTAGDVARTIN--ENRGVKNNIQRRV--------- 784
             |||.:.:           .|.|...:||.....::.:.|:  :.|.::::.|..|         
Mouse  1124 VTVQNYFIVMVPLRKSRGGQFPVLLGSPEDMDLEELIQDISRLQRRSLRHSRQLEVPRPYIAARF 1188

  Fly   785 ----------------GF----------YVLHAGVGDVIKDLQ--DPSVSSSRIELAEQ--GPD- 818
                            ||          |||.     |:..||  :|:.::|......|  .|| 
Mouse  1189 SILPAVFHPGNQKQYGGFDNRGLEPGHRYVLF-----VLAVLQKNEPTFAASPFSDPFQLDNPDP 1248

  Fly   819 -------------VTHIMAYMFAGAGAAAVIVIFVTLILIK-RHDRKRDKLGGLQSGIAGAETCS 869
                         :..::|.:|       :|.|.:.::|.| :.|.||                 
Mouse  1249 QPIVDGEEGLIWVIGPVLAVVF-------IICIVIAILLYKNKPDSKR----------------- 1289

  Fly   870 KDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPA 934
            ||.:...:..:         :....|.....:|....||...:......||.            .
Mouse  1290 KDSEPRTKCLL---------NNADLAPHHPKDPVEMRRINFQTPGMLSHPPI------------P 1333

  Fly   935 LTNMDISTGHMVLSYMEDHLRNKGRLQREWEAL---CRYEAEPSAREAASQPQCAGLNRPGAPLP 996
            :|:|   ..||......|.|    :|.:|:|::   .::..|.|..| |::|:    ||....:.
Mouse  1334 ITDM---AEHMERLKANDSL----KLSQEYESIDPGQQFTWEHSNLE-ANKPK----NRYANVIA 1386

  Fly   997 YDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALC 1061
            ||||||:|..|....|.||:||:.: |...|..||:|.|||||.|...||:|:|||.:..:|.:.
Mouse  1387 YDHSRVILQPLEGIMGSDYINANYV-DGYRRQNAYIATQGPLPETFGDFWRMVWEQRSATVVMMT 1450

  Fly  1062 RLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSW 1126
            ||:|...:.|.:|||..|.|.|...:|.|: :.:....:.||:|.|....:||.|.|..|.|.:|
Mouse  1451 RLEEKSRIKCDQYWPNRGTETYGFIQVTLL-DTMELATFCVRTFSLHKNGSSEKREVRHFQFTAW 1514

  Fly  1127 PHMGVPAQAKALLDFRRKVNKSYRGRRSC------PIVVHGSAGAGRTGVYILLDLVLERMNKGA 1185
            |..|||......|.|.|:|       ::|      |||||.|||.||||.:|::|.:|||: |..
Mouse  1515 PDHGVPEYPTPFLAFLRRV-------KTCNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERI-KTE 1571

  Fly  1186 REIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANT 1233
            :.:|:...:..:|.||..:|.|..|:.|:..|:.|.|......:||.:
Mouse  1572 KTVDVYGHVTLMRSQRNYMVQTEDQYGFIHEALLEAVGCGNTEVPARS 1619

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IA-2NP_608562.4 Receptor_IA-2 705..795 CDD:463293 24/164 (15%)
PTP_DSP_cys 942..1225 CDD:475123 106/291 (36%)
PtprsNP_035348.2 I-set 33..124 CDD:400151
Ig strand B 50..54 CDD:409570
Ig strand C 63..67 CDD:409570
Important for binding to glycosaminoglycan chains. /evidence=ECO:0000269|PubMed:19833921, ECO:0000269|PubMed:21454754 68..72
Ig strand E 86..93 CDD:409570
Ig strand F 104..109 CDD:409570
Ig strand G 117..120 CDD:409570
IgI_2_RPTP_IIa_LAR_like 137..226 CDD:409400
Ig strand A' 143..147 CDD:409400
Ig strand B 150..159 CDD:409400
Ig strand C 164..170 CDD:409400
Ig strand C' 172..174 CDD:409400
Ig strand D 183..187 CDD:409400
Ig strand E 190..195 CDD:409400
Ig strand F 204..211 CDD:409400
Ig strand G 214..225 CDD:409400
IgI_3_RPTP_IIa_LAR_like 235..316 CDD:409401
Ig strand A 235..237 CDD:409401
Ig strand A' 241..245 CDD:409401
Ig strand B 248..256 CDD:409401
Ig strand C 261..267 CDD:409401
Ig strand C' 269..271 CDD:409401
Ig strand D 274..278 CDD:409401
Ig strand E 283..288 CDD:409401
Ig strand F 295..302 CDD:409401
Ig strand G 306..315 CDD:409401
FN3 309..815 CDD:442628 65/325 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 691..711 3/19 (16%)
FN3 916..1004 CDD:238020 29/139 (21%)
FN3 1009..1092 CDD:238020 21/100 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1286..1313 6/52 (12%)
R-PTPc-S-1 1329..1610 CDD:350473 110/314 (35%)
R-PTP-S-2 1612..1901 CDD:350475 2/8 (25%)
Blue background indicates that the domain is not in the aligned region.

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