Protein Alignment IA-2 and Ptprr

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_035347.1
• Gene: Ptprr / 19279
• MGIID: 109559
• Length: 656
• Species: Mus musculus
• Alignment Length: 647
• Identity: 154/647 - (23%)
• Similarity: 268/647 - (41%)
• Gaps: 128/647 - (19%)

  Fly   658 AHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVKN--PIDSWN 720
            |.:||    |...|..|..:.: |..|...:.::.:....|:|..|.....|..:.:  |..:::
Mouse    31 AIRQK----KSWKPVFIYDHSQ-DIKKSLDIAQEAYKHNYHSPSEVQISKHHQIINSAFPRPAYD 90

  Fly   721 DGQRIMKELEQ-------------------------------------------ILHMQGYFSYL 742
            ....::.|.:|                                           :|..|.:.:.|
Mouse    91 PSLNLLAESDQDLEIENLPIPAANVIVVTLQMDITKLNITLLRIFRQGVAAALGLLPQQVHINRL 155

  Fly   743 TVQQHEVSFRVNSNNPERK-------TAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVI--K 798
            ..::::|...|:..|  ||       .|.:|.|::|.: |:..::.:        .|:.||.  |
Mouse   156 IEKKNQVELFVSPGN--RKPGETQALQAEEVLRSLNVD-GLHQSLPQ--------FGITDVAPEK 209

  Fly   799 DLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILI-----------KRHDRKR 852
            ::......:.:| .:::|         .:|.....::.:|.||.::|           .|.|:::
Mouse   210 NVLQGQHEADKI-WSKEG---------FYAVVIFLSIFIIIVTCLMIIYRLKERLQLSLRQDKEK 264

  Fly   853 DKLGGLQSGIA--GAETCSKDYQELCRARMAGK-----AGGGGNSTGGAAGGGSNEPAPSG-RIT 909
            ::...| |.||  .|::.:|....:.:...|.|     ....|..|.......|....||. |:.
Mouse   265 NQEIHL-SPIARQQAQSEAKTTHSMVQPDQAPKVLNVVVDPQGQCTPEIRNSTSTSVCPSPFRMK 328

  Fly   910 SLS-KENEGRPPSSRSSTSS-WSEEP-----------ALTNMDISTGHMVLSYMEDHLRNKGRLQ 961
            .:. :|..|...|.....|| .|.||           |:..:..::..:..|.:.|.:.:...||
Mouse   329 PIGLQERRGSNVSLTLDMSSLGSVEPFVAVSTPREKVAMEYLQSASRVLTRSQLRDVVASSHLLQ 393

  Fly   962 REWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLD-YVNASTITDHD 1025
            .|:..:.....:|...:.   |:....||....||...|||.|......:.|. |:||:.|..:.
Mouse   394 SEFMEIPMNFVDPKEIDI---PRHGTKNRYKTILPNPLSRVCLRPKNITDSLSTYINANYIRGYS 455

  Fly  1026 PRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHL 1090
            .:..|::|.|||:.:|:..||||:|::.:.|||.:.:|:|..| .|..||||:.. :|...|| |
Mouse   456 GKEKAFIATQGPMINTVNDFWQMVWQEDSPVIVMITKLKEKNE-KCVLYWPEKRG-IYGKVEV-L 517

  Fly  1091 VSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK---SYRGR 1152
            |:....||:|.:|:..||  :.|.|:.|..:.:.|||....|..|:.||.....|.:   :..||
Mouse   518 VTGVTECDNYTIRNLVLK--QGSHTQHVKHYWYTSWPDHKTPDSAQPLLQLMLDVEEDRLASEGR 580

  Fly  1153 RSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFV 1214
            .  |:|||.|||.||||.:|...:..::: |....:|..:.:..||..|.|:|.|.:|:|||
Mouse   581 G--PVVVHCSAGIGRTGCFIATSIGCQQL-KEEGVVDALSIVCQLRVDRGGMVQTSEQYEFV 639

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	18/141 (13%)
		PTP_DSP_cys	942..1225	CDD:475123	90/277 (32%)
Ptprr	NP_035347.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	269..289		6/20 (30%)
		R-PTPc-R	416..641	CDD:350459	83/232 (36%)