DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IA-2 and Ptprn2

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_035345.2	Gene:	Ptprn2 / 19276	MGIID:	107418	Length:	1001	Species:	Mus musculus

Alignment Length:	1185	Identity:	399/1185 - (33%)
Similarity:	543/1185 - (45%)	Gaps:	302/1185 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   157 LLLILLL------------ATHGDLAQAEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDV 209
            |||:|||            :..|  .|..|.:||.|...|| ...|.|.:|.:||:|.....:|.
Mouse     7 LLLLLLLPPPLPRALPAPASARG--RQLPGRLGCLFEDGLC-GSLETCVNDGVFGRCQKVPVMDT 68

  Fly   210 EDIEKTP--LTEDQSRVLATMLEELQGAGLGWDHPYVQCRIQGSL-------------------- 252
            ...|..|  |..     |...|::|...|..|...|.|..|...|
Mouse    69 YRYEVPPGALLH-----LKVTLQKLSRTGFTWQDDYTQRVIAQELANLPKAYLWHGEASGPARSL 128

  Fly   253 ---------FSLQRQQQLPPNL--------------CAN--------LAPTPPEFGDPASALAYV 286
                     |||:|:..|...|              .||        ..|...|...|.:.|.||
Mouse   129 QQNADNEKWFSLEREVALAKTLRRYLPYLELLSQTPTANAHSRIDHETRPAKGEDSSPENILTYV 193

  Fly   287 RFTPPEPEAELDYYEQPAGPAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHDPSELEHFGKM 351
            ..|     :.|.|      |    ||.|.|          |.:.:|:...||:  |.||.  .|:
Mouse   194 AHT-----SALTY------P----PATRAK----------YPDNLLRPFSRLQ--PDELS--PKV 229

  Fly   352 DGHGQSTQLDAPSIMDAFLDTERQRIEREQQLAA-AEQDADRRAEQNRLELYQILAASEPDPQPY 415
            ||                 |.::|::     :|| ....|.|...:|..|...::..|...|:|:
Mouse   230 DG-----------------DIDKQKL-----IAALGAYTAQRLPGENDPEPRYLVHGSARAPRPF 272

  Fly   416 ------QRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPF 474
                  ||.|....:|.|......:...|..||:.|:.::.                  |...|.
Mouse   273 SATALSQRWPPPPGDAKDSPSMDDDTLLQSLLKDLQQNSEV------------------DRLGPL 319

  Fly   475 KRARGRSRGGLAEEVEDEQPKRSFFRELAG---EQGLVQEPPLRFRHVETEVDATPELVKRRPAS 536
            |..:..|..|..:....|..:.|..|...|   ||....|..|: .|..:|||
Mouse   320 KEEKADSVAGAIQSDPAEGSQESHGRGAEGQPREQTDAPETMLQ-DHRLSEVD------------ 371

  Fly   537 FKQLDPYDVSLQQQEMAFESG-LLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQD-- 598
                ||  |..:...::|:.| ||::..:||..|..|...|...:.|...         .|::
Mouse   372 ----DP--VYKEVNRLSFQLGDLLKDYGSPLLPEGPLLEKSSREEIKKSE---------QPEEVL 421

  Fly   599 --EQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGP------------------------ 637
              |::|.|:     |:|:....:..|    .||....:|.|
Mouse   422 SSEEETAGV-----EHVRSRTYSKDL----FERKPNSEPQPRRLEDQFQNRAPELWEDEESLKLA 477

  Fly   638 LLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHT 702
            ..||||.|.     |||.:.:.:|:|:        .:.||
Mouse   478 AQGPPSGGL-----QLEVQPSEEQQGY--------ILTGN------------------------- 504

  Fly   703 VDTEYVHVFVKNPIDSWNDGQRIMKELEQILHM-QGYFSYLTVQQHEVSFRVNSNNPERKTAGDV 766
                       ||: |...|:::|.::..||.: ..:|:.:.|....|:|:| |.|.:..|..||
Mouse   505 -----------NPL-SPEKGKQLMDQVAHILRVPSSFFADIKVLGPAVTFKV-SANIQNMTTADV 556

  Fly   767 ARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAG 831
            .:...:|   |:.:::..|..:|.:|:        .|......:...|:..|.|..:...|....
Mouse   557 IKAAADN---KDQLEKATGLTILQSGI--------RPKGKLKLLPHQEEQEDSTKFILLTFLSIA 610

  Fly   832 AAAVIVIFVTLILIKRHD---RKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGG 893
            ....:::..:|....||:   :.:|||.||  |...:...::.||||||.|||.:.
Mouse   611 CILGVLLASSLAYCLRHNSHYKLKDKLSGL--GADPSADATEAYQELCRQRMAIRP--------- 664

  Fly   894 AAGGGSNEPAPSGRITSLSKENEGRP---PSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLR 955
               ...:|...:.||.|:|.:....|   ||:|||||||||||..:|||||||||:|:||||||:
Mouse   665 ---QDRSEGPHTSRINSVSSQFSDGPMPSPSARSSTSSWSEEPVQSNMDISTGHMILAYMEDHLK 726

  Fly   956 NKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNAST 1020
            ||.||::||||||.|:|||::...|.:.:.|..||..|.|.|||||::|....:....||:|||.
Mouse   727 NKNRLEKEWEALCAYQAEPNSSLVAQREENAPKNRSLAVLTYDHSRILLKSQNSHGSSDYINASP 791

  Fly  1021 ITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHI 1085
            |.|||||.|||:|.|||||:|:|.||||:||.|..|||.|..|.|||...|..|||:||:.:||:
Mouse   792 IMDHDPRNPAYIATQGPLPATVADFWQMVWESGCAVIVMLTPLSENGVRQCHHYWPDEGSNLYHV 856

  Fly  1086 YEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYR 1150
            |||:||||||||.|:||||||||||:|:|||||||||||||...|||:..::||||||||||.||
Mouse   857 YEVNLVSEHIWCQDFLVRSFYLKNLQTNETRTVTQFHFLSWYDQGVPSSTRSLLDFRRKVNKCYR 921

  Fly  1151 GRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVL 1215
            | |||||:||.|.||||:|.|:|:|:||.:|.|||:|||||||||||||||.|:|.|::||||.|
Mouse   922 G-RSCPIIVHCSDGAGRSGTYVLIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFEFAL 985

  Fly  1216 MAVAEEVHAILKALP 1230
            .||||||:|||||||
Mouse   986 TAVAEEVNAILKALP 1000

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	22/87 (25%)
		PTPc	960..1220	CDD:214550	167/259 (64%)
		PTPc	995..1220	CDD:238006	151/224 (67%)
Ptprn2	NP_035345.2	Involved in localization to secretory granules, interaction with CPE. /evidence=ECO:0000269\|PubMed:21210912	1..407		113/495 (23%)
		RESP18	72..>126	CDD:291609	12/58 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	271..296		6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	308..359		12/68 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	394..459		17/82 (21%)
		Receptor_IA-2	498..583	CDD:288410	25/141 (18%)
		Tyrosine-based internalization motif. /evidence=ECO:0000250\|UniProtKB:Q63475	652..661		7/8 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	663..705		18/53 (34%)
		PTPc	731..990	CDD:214550	167/259 (64%)
		PTPc	758..990	CDD:238006	154/232 (66%)
		Substrate binding. /evidence=ECO:0000250	931..937		3/5 (60%)
		Leucine-based sorting signal. /evidence=ECO:0000305\|PubMed:16262730	990..996		4/5 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	328	1.000	Domainoid score	I1168
eggNOG	1	0.900	-	-		E2759_KOG0793
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	516	1.000	Inparanoid score	I1275
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281324at33208
OrthoFinder	1	1.000	-	-		FOG0002390
OrthoInspector	1	1.000	-	-		otm44306
orthoMCL	1	0.900	-	-		OOG6_105521
Panther	1	1.100	-	-	O	PTHR46106
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5067
SonicParanoid	1	1.000	-	-		X1583
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	14	13.860