DRSC/TRiP Functional Genomics Resources

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Protein Alignment IA-2 and Ptprn

DIOPT Version :9

Sequence 1:NP_608562.4 Gene:IA-2 / 33277 FlyBaseID:FBgn0031294 Length:1319 Species:Drosophila melanogaster
Sequence 2:NP_033011.2 Gene:Ptprn / 19275 MGIID:102765 Length:981 Species:Mus musculus


Alignment Length:1197 Identity:402/1197 - (33%)
Similarity:532/1197 - (44%) Gaps:308/1197 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly   124 RREVRGCGAGGGG------LLCCSLDALSRPAKLLQFGVLLLILLLATHGDLAQAEGNVGCQFVR 182
            ||..|..|:||.|      ||.|                  |:||....|..:....: ||.|.|
Mouse     2 RRPRRPGGSGGSGGSGGLRLLVC------------------LLLLSGRPGGCSAISAH-GCLFDR 47

  Fly   183 TLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATM---LEELQGAGLGWDHPYV 244
            .|| .|.|||..|.:||:|....|      :..||.:..|.||..:   |.:|...||.|.....
Mouse    48 RLC-SHLEVCIQDGLFGQCQAGVG------QARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLT 105

  Fly   245 QCRIQGSLFSLQRQQQLP--------PNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYE 301
            |..|.      |..:::|        |...:.|.|..|  |.....|.....|...|.|:  .:.
Mouse   106 QHVIS------QEMERIPRLRPPEPHPRDRSGLVPRKP--GPAGELLTQGNPTGSSPAAQ--GFP 160

  Fly   302 QPAG--------------PAQFYPALRKKQVRESDADDMYLNRMLQDRR----RLRHDPSELE-- 346
            :|||              .|:..|.|              |..:|...:    .|.::|:.|:  
Mouse   161 RPAGGGDGAGAGSPLSSLQAELLPPL--------------LEHLLMPPQPPHPALTYEPALLQPY 211

  Fly   347 ---HFGKMDG-HGQSTQLDAPSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAA 407
               .||..|| .|..:......:               ..|:.||                    
Mouse   212 LFHQFGSRDGSRGSESSSGVVGV---------------GHLSKAE-------------------- 241

  Fly   408 SEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFA 472
               .|..:.|..:         :||:.........:....:.|.::      .:|..||......
Mouse   242 ---GPALFSRSAS---------KAILGTHSGHSFGDLTGPSPAQLF------QDSGLLYMAQELP 288

  Fly   473 PFKRARG----RSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPELVKRR 533
            ...|||.    .:.|..||:..:...:     |:.|.:| .:.||..         |.|||..:|
Mouse   289 VPGRARAPRLPENGGNRAEDSSEGHEE-----EVLGGRG-EKSPPQA---------AQPELSLQR 338

  Fly   534 PASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQD 598
            ..:.  |..|.|.|:|             |||.:...:|..                 |.|:|:.
Mouse   339 LTAV--LAGYGVELRQ-------------LTPEQFSTLLTL-----------------LQLLPKG 371

  Fly   599 EQDTDGMQADEPENVKQSLLANMLGFARHERLDVKK---------PGPLLGP-PSL--------G 645
                .|...:...||         |.|     ||||         |...|.| |||        .
Mouse   372 ----TGRNLEGAVNV---------GGA-----DVKKTIQQMQRGDPAEALPPTPSLPGYLTASPA 418

  Fly   646 SAELSNQLE---TEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQ----------HSAED 697
            |:|:...|.   .|..|.....|:..||           ..||..:.:.|          .|||:
Mouse   419 SSEVQQVLSPGFPEPPHTPSPLGSSSVL-----------LEKKSPLGQSQPTVVGRPSARPSAEE 472

  Fly   698 HAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHM-QGYFSYLTVQQHEVSFRVNSNNPERK 761
            :.....|        :.|: |...|.|:::.|.:.:|| .|.|..::|....|:||:..|.....
Mouse   473 YGYIVTD--------QKPL-SLVAGVRLLEILAEHVHMSSGSFINISVVGPAVTFRIRHNEQNLS 528

  Fly   762 TAGDVARTINENRG-VKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTH---- 821
            .|     .:.:..| ||:.::.:.|..:|..|||             .|.|.||..|...|    
Mouse   529 LA-----DVTQQAGLVKSELEAQTGLQILQTGVG-------------QREEAAEVLPRQAHGISP 575

  Fly   822 ---IMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDK--LGGLQSGIAGAETCSKDYQELCRARMA 881
               ::..:.|.||.|.::|.....:.::.|.|:|||  |..|....|..:| :.:||:|||..||
Mouse   576 MRSVLLTLVALAGVAGLLVALAVALCMRHHSRQRDKERLAALGPEGAHGDT-TFEYQDLCRQHMA 639

  Fly   882 GKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEG---RPPSSRSSTSSWSEEPALTNMDISTG 943
            .|      |....|.|   :|.|| |::|:|.:...   ..|||.|||.||.||||..|||||||
Mouse   640 TK------SLFNRAEG---QPEPS-RVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTG 694

  Fly   944 HMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLA 1008
            ||:|:||||||||:.||.:||:|||.|:|||:...||........||....|||||:|:.|...:
Mouse   695 HMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCAAAQDESNIKKNRHPDFLPYDHARIKLKVES 759

  Fly  1009 NAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACAR 1073
            :....||:|||.|.:||||.|||:|.||||..|:|.||||:||.|..|||.|..|.|:|...|.|
Mouse   760 SPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDR 824

  Fly  1074 YWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKAL 1138
            |||:||:.:||:|||:||||||||:|:||||||||||:|.||||:|||||||||..|.||..:.|
Mouse   825 YWPDEGSSLYHVYEVNLVSEHIWCEDFLVRSFYLKNLQTQETRTLTQFHFLSWPAEGTPASTRPL 889

  Fly  1139 LDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAG 1203
            |||||||||.||| |||||:||.|.||||||.|||:|:||.||.||.:||||||||||:||||.|
Mouse   890 LDFRRKVNKCYRG-RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPG 953

  Fly  1204 VVATRQQFEFVLMAVAEEVHAILKALP 1230
            :|.::.||||.|.||||||:|||||||
Mouse   954 LVRSKDQFEFALTAVAEEVNAILKALP 980

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
IA-2NP_608562.4 Receptor_IA-2 708..795 CDD:288410 22/88 (25%)
PTPc 960..1220 CDD:214550 163/259 (63%)
PTPc 995..1220 CDD:238006 149/224 (67%)
PtprnNP_033011.2 RESP18 homology domain. /evidence=ECO:0000250|UniProtKB:Q16849 38..134 31/109 (28%)
RESP18 63..141 CDD:291609 22/91 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 291..332 12/55 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 394..445 12/50 (24%)
Sufficient for dimerization of proICA512. /evidence=ECO:0000250|UniProtKB:Q16849 451..577 34/152 (22%)
Receptor_IA-2 474..559 CDD:288410 24/111 (22%)
Sufficient for dimerization of proICA512. /evidence=ECO:0000250|UniProtKB:P80560 603..734 69/141 (49%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 646..682 16/39 (41%)
PTPc 711..970 CDD:214550 163/259 (63%)
PTPc 738..970 CDD:238006 151/232 (65%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 328 1.000 Domainoid score I1168
eggNOG 1 0.900 - - E2759_KOG0793
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 516 1.000 Inparanoid score I1275
Isobase 1 0.950 - 0 Normalized mean entropy S3974
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002390
OrthoInspector 1 1.000 - - otm44306
orthoMCL 1 0.900 - - OOG6_105521
Panther 1 1.100 - - LDO PTHR46106
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R5067
SonicParanoid 1 1.000 - - X1583
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1312.800

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