Protein Alignment IA-2 and Ptprn

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_033011.2
• Gene: Ptprn / 19275
• MGIID: 102765
• Length: 981
• Species: Mus musculus
• Alignment Length: 1197
• Identity: 402/1197 - (33%)
• Similarity: 532/1197 - (44%)
• Gaps: 308/1197 - (25%)

  Fly   124 RREVRGCGAGGGG------LLCCSLDALSRPAKLLQFGVLLLILLLATHGDLAQAEGNVGCQFVR 182
            ||..|..|:||.|      ||.|                  |:||....|..:....: ||.|.|
Mouse     2 RRPRRPGGSGGSGGSGGLRLLVC------------------LLLLSGRPGGCSAISAH-GCLFDR 47

  Fly   183 TLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATM---LEELQGAGLGWDHPYV 244
            .|| .|.|||..|.:||:|....|      :..||.:..|.||..:   |.:|...||.|.....
Mouse    48 RLC-SHLEVCIQDGLFGQCQAGVG------QARPLLQVTSPVLQRLQGVLRQLMSQGLSWHDDLT 105

  Fly   245 QCRIQGSLFSLQRQQQLP--------PNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYE 301
            |..|.      |..:::|        |...:.|.|..|  |.....|.....|...|.|:  .:.
Mouse   106 QHVIS------QEMERIPRLRPPEPHPRDRSGLVPRKP--GPAGELLTQGNPTGSSPAAQ--GFP 160

  Fly   302 QPAG--------------PAQFYPALRKKQVRESDADDMYLNRMLQDRR----RLRHDPSELE-- 346
            :|||              .|:..|.|              |..:|...:    .|.::|:.|:
Mouse   161 RPAGGGDGAGAGSPLSSLQAELLPPL--------------LEHLLMPPQPPHPALTYEPALLQPY 211

  Fly   347 ---HFGKMDG-HGQSTQLDAPSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAA 407
               .||..|| .|..:......:               ..|:.||
Mouse   212 LFHQFGSRDGSRGSESSSGVVGV---------------GHLSKAE-------------------- 241

  Fly   408 SEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFA 472
               .|..:.|..:         :||:.........:....:.|.::      .:|..||......
Mouse   242 ---GPALFSRSAS---------KAILGTHSGHSFGDLTGPSPAQLF------QDSGLLYMAQELP 288

  Fly   473 PFKRARG----RSRGGLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPELVKRR 533
            ...|||.    .:.|..||:..:...:     |:.|.:| .:.||..         |.|||..:|
Mouse   289 VPGRARAPRLPENGGNRAEDSSEGHEE-----EVLGGRG-EKSPPQA---------AQPELSLQR 338

  Fly   534 PASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQD 598
            ..:.  |..|.|.|:|             |||.:...:|..                 |.|:|:.
Mouse   339 LTAV--LAGYGVELRQ-------------LTPEQFSTLLTL-----------------LQLLPKG 371

  Fly   599 EQDTDGMQADEPENVKQSLLANMLGFARHERLDVKK---------PGPLLGP-PSL--------G 645
                .|...:...||         |.|     ||||         |...|.| |||        .
Mouse   372 ----TGRNLEGAVNV---------GGA-----DVKKTIQQMQRGDPAEALPPTPSLPGYLTASPA 418

  Fly   646 SAELSNQLE---TEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQ----------HSAED 697
            |:|:...|.   .|..|.....|:..||           ..||..:.:.|          .|||:
Mouse   419 SSEVQQVLSPGFPEPPHTPSPLGSSSVL-----------LEKKSPLGQSQPTVVGRPSARPSAEE 472

  Fly   698 HAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHM-QGYFSYLTVQQHEVSFRVNSNNPERK 761
            :.....|        :.|: |...|.|:::.|.:.:|| .|.|..::|....|:||:..|.....
Mouse   473 YGYIVTD--------QKPL-SLVAGVRLLEILAEHVHMSSGSFINISVVGPAVTFRIRHNEQNLS 528

  Fly   762 TAGDVARTINENRG-VKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTH---- 821
            .|     .:.:..| ||:.::.:.|..:|..|||             .|.|.||..|...|
Mouse   529 LA-----DVTQQAGLVKSELEAQTGLQILQTGVG-------------QREEAAEVLPRQAHGISP 575

  Fly   822 ---IMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDK--LGGLQSGIAGAETCSKDYQELCRARMA 881
               ::..:.|.||.|.::|.....:.::.|.|:|||  |..|....|..:| :.:||:|||..||
Mouse   576 MRSVLLTLVALAGVAGLLVALAVALCMRHHSRQRDKERLAALGPEGAHGDT-TFEYQDLCRQHMA 639

  Fly   882 GKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEG---RPPSSRSSTSSWSEEPALTNMDISTG 943
            .|      |....|.|   :|.|| |::|:|.:...   ..|||.|||.||.||||..|||||||
Mouse   640 TK------SLFNRAEG---QPEPS-RVSSVSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTG 694

  Fly   944 HMVLSYMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLA 1008
            ||:|:||||||||:.||.:||:|||.|:|||:...||........||....|||||:|:.|...:
Mouse   695 HMILAYMEDHLRNRDRLAKEWQALCAYQAEPNTCAAAQDESNIKKNRHPDFLPYDHARIKLKVES 759

  Fly  1009 NAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACAR 1073
            :....||:|||.|.:||||.|||:|.||||..|:|.||||:||.|..|||.|..|.|:|...|.|
Mouse   760 SPSRSDYINASPIIEHDPRMPAYIATQGPLSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDR 824

  Fly  1074 YWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKAL 1138
            |||:||:.:||:|||:||||||||:|:||||||||||:|.||||:|||||||||..|.||..:.|
Mouse   825 YWPDEGSSLYHVYEVNLVSEHIWCEDFLVRSFYLKNLQTQETRTLTQFHFLSWPAEGTPASTRPL 889

  Fly  1139 LDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAG 1203
            |||||||||.||| |||||:||.|.||||||.|||:|:||.||.||.:||||||||||:||||.|
Mouse   890 LDFRRKVNKCYRG-RSCPIIVHCSDGAGRTGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPG 953

  Fly  1204 VVATRQQFEFVLMAVAEEVHAILKALP 1230
            :|.::.||||.|.||||||:|||||||
Mouse   954 LVRSKDQFEFALTAVAEEVNAILKALP 980

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	22/91 (24%)
		PTP_DSP_cys	942..1225	CDD:475123	181/282 (64%)
Ptprn	NP_033011.2	RESP18 homology domain. /evidence=ECO:0000250|UniProtKB:Q16849	38..134		31/109 (28%)
		RESP18	63..150	CDD:464394	23/100 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	291..332		12/55 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	394..445		12/50 (24%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250|UniProtKB:Q16849	451..577		34/152 (22%)
		Receptor_IA-2	471..559	CDD:463293	25/114 (22%)
		Sufficient for dimerization of proICA512. /evidence=ECO:0000250|UniProtKB:P80560	603..734		69/141 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	646..682		16/39 (41%)
		R-PTP-N	695..975	CDD:350457	179/280 (64%)