Protein Alignment IA-2 and Ptprj

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_006499054.1
• Gene: Ptprj / 19271
• MGIID: 104574
• Length: 1351
• Species: Mus musculus
• Alignment Length: 1349
• Identity: 265/1349 - (19%)
• Similarity: 447/1349 - (33%)
• Gaps: 435/1349 - (32%)

  Fly   135 GGLLCC--------SLDALSRPAKLLQFGVLLLILLLATHGDLAQAEGNVGCQFVRTLCIP--HS 189
            |.:||.        .::|:..|..         :||...|.|...:|..:..:....|..|  :.
Mouse   143 GQVLCAGAAPNPIFDIEAVVSPTS---------VLLTWKHNDSGASECRIENKMESNLTFPVKNQ 198

  Fly   190 EVCYDDNIFG---------------------KCIPTTGVDVEDIEKTPLTEDQSRV--------- 224
            ..|   ||.|                     |.|.|....|.|:..|.:...|:|:
Mouse   199 TSC---NITGLSPGTSYTFSIISVTTNETLNKTITTEPWPVSDLHVTSVGVTQARLTWSNANGTA 260

  Fly   225 -LATMLEEL--------QGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLCAN------------ 268
             ...::|||        .|...|.::.:.......:.......:::|.:  ||
Mouse   261 SYRMLIEELTTHSSVNISGLKPGTNNSFAFPESNETQADFAVAEEVPAD--ANGTKRIPVTNLSQ 323

  Fly   269 ------LAPTPPEFGDPASALAYVRFTPPEPEAELD--YYEQPAGPAQFYPALRKKQVRESDADD 325
                  ::..||...||  :|..:..|..:|:.:.:  .|.|.|...:..|  |.|..:.:
Mouse   324 LHKNSLVSVDPPSGQDP--SLTEILLTDLKPDTQYNATIYSQAANGTEGQP--RNKVFKTN---- 380

  Fly   326 MYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIMDAFLDTERQRIEREQQLAAAEQDA 390
               :..:.|.|.:....|.:....|.:..|..|.:.....:.....:..|.:.:.:.:......:
Mouse   381 ---STQVSDVRAMNISASSMTLTWKSNYDGSRTSIVYKIHVAGGTHSVNQTVNKTEAIILGLSSS 442

  Fly   391 DRRAEQNRLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVP 455
                     .||.|..      .|:..:....|..:.                        ||..
Mouse   443 ---------TLYNITV------HPFLGQTEGTPGFLQ------------------------VYTS 468

  Fly   456 PEEVNE---------------------SSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFF 499
            |::|::                     |.|::...:..  ::.|..|.|..:..|||.:|..|:.
Mouse   469 PDQVSDFRVTNVSTRAIGLAWRSNDSKSFEIFIKQDGG--EKHRNASTGNQSYMVEDLKPGTSYH 531

  Fly   500 RELA-----GEQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLDPYDVSLQQQEMAFE---- 555
            .|:.     |.:||           .:.|:.:.:     |::...:...::|..:.::.::
Mouse   532 FEIIPRGPDGTEGL-----------SSTVNGSTD-----PSAVTDIRVVNISTTEMQLEWQNTDD 580

  Fly   556 -SGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGL--------LLMPQDEQDTDGM-----Q 606
             ||...:.:...:..:::.:||      ||:..|.|.|        .:.|:.:| ..|:     |
Mouse   581 ASGYTYHLVLESKSGSIIRTNS------SQKWITVGSLTPGTLYNVTIFPEVDQ-IQGISNSITQ 638

  Fly   607 ADEPENVKQ--------------------------SLLANMLGFARHERLDVKKPGPLLGPPSLG 645
            ...|.:|..                          |:|....|...:...:..|...:|.|..:.
Mouse   639 YTRPSSVSHIEVNTTTTTAAIRWKNEDAASASYAYSVLILKTGDGSNVTSNFTKDPSILIPELIP 703

  Fly   646 SAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHV 710
            ....     |.|...|.|.|...::|.......|                    |..|.:.:..|
Mouse   704 GVSY-----TVKILTQVGDGTTSLVPGWNLFCTE--------------------PEPVTSFHCEV 743

  Fly   711 FVKNPI---------------------DSWNDGQRIMKELEQILHMQ--------GYFSYLTVQQ 746
            ..|.|.                     |||::    |..||......        .|.::.|  .
Mouse   744 VPKEPALVLKWACPFGMYTGFELGVRSDSWDN----MTRLENCTSDDDTECRTEVAYLNFST--S 802

  Fly   747 HEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDP---SVSSS 808
            :.:|....|.......|.::..|                      |:.|.......|   |||.:
Mouse   803 YNISIATLSCGKMALPAQNICTT----------------------GITDPPTPDGSPNITSVSHN 845

  Fly   809 RIELAEQGPDVTH--IMAY-MFAGAGAAA---VIVIFVTLILIKRHDRKRDKLGGLQSGIAGAET 867
            .:::...|.:.:|  |.|| :....|.||   ..|:..|.     .|.||           ||..
Mouse   846 SVKVKFSGFEASHGPIKAYAVILTTGEAAQPSADVLKYTY-----EDFKR-----------GASD 894

  Fly   868 CSKDYQELCRARMAGKAGG-----------GGNSTGGAAGGGSNEPAPSGR-----ITSL--SKE 914
            ....|  |.|....|::.|           |..||......|..||..|.|     .|::  :.:
Mouse   895 TYVTY--LIRIEEKGQSQGLSEVLNYEIDVGNQSTTLGYYNGRLEPLGSYRACVAGFTNITYNLQ 957

  Fly   915 NEG--RPPSSRSSTSSWSE------EP---------------ALT-----------NMDISTGHM 945
            |:|  ....|..|.|.:||      :|               |:|           ..|.....:
Mouse   958 NDGLINGDESYVSFSPYSEAVFLPQDPGVICGAVFGCIFGALAITAVGGFIFWRKKRTDAKNNEV 1022

  Fly   946 VLSYMEDHLRNKGRLQR---------------------EWE-------ALCRYEAEPSAREAASQ 982
            ..|.::.   .|.:|.|                     |:|       :|.:|.||.:...
Mouse  1023 SFSQIKP---KKSKLIRVENFEAYFKKQQADSNCGFAEEYEDLKLIGISLPKYTAEIAENR---- 1080

  Fly   983 PQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQ 1047
                |.||....||||.|||.|:...::.. ||:||:.:..:..:.. ::|.|||||:||..||:
Mouse  1081 ----GKNRYNNVLPYDISRVKLSVQTHSTD-DYINANYMPGYHSKKD-FIATQGPLPNTLKDFWR 1139

  Fly  1048 MIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRT 1112
            |:||:....||.|.:..|.|...|..|||.:.|:.|....|.:.|| :...::.:|.|.:||::.
Mouse  1140 MVWEKNVYAIVMLTKCVEQGRTKCEEYWPSKQAQDYGDITVAMTSE-VVLPEWTIRDFVVKNMQN 1203

  Fly  1113 SETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGR--RSCPIVVHGSAGAGRTGVYILLD 1175
            ||:..:.||||.|||..|||.....|::||..| :.|..:  ...||:||.|||.||||.:|.:|
Mouse  1204 SESHPLRQFHFTSWPDHGVPDTTDLLINFRYLV-RDYMKQIPPESPILVHCSAGVGRTGTFIAID 1267

  Fly  1176 LVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA 1224
            .::.:: :....:|:...:..||..|..:|.|..|:.|:...|.:.:.|
Mouse  1268 RLIYQI-ENENTVDVYGIVYDLRMHRPLMVQTEDQYVFLNQCVLDIIRA 1315

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	16/118 (14%)
		PTP_DSP_cys	942..1225	CDD:475123	96/313 (31%)
Ptprj	XP_006499054.1	fn3	162..222	CDD:394996	12/71 (17%)
		FN3	199..699	CDD:442628	86/579 (15%)
		PTP_tm	849..979	CDD:465889	36/147 (24%)
		R-PTPc-J	1083..1311	CDD:350463	84/232 (36%)