Protein Alignment IA-2 and Ptpn20

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_006518791.1
• Gene: Ptpn20 / 19256
• MGIID: 1196295
• Length: 463
• Species: Mus musculus
• Alignment Length: 351
• Identity: 112/351 - (31%)
• Similarity: 163/351 - (46%)
• Gaps: 35/351 - (9%)

  Fly   889 NSTGGAAGGGSNEPAP--SGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYME 951
            ||......|.|...:|  ||. :.|||:.| ...|.:..|......|.:.|   |:....:....
Mouse   132 NSMDSETAGPSKTVSPVLSGS-SRLSKDTE-TSVSEKELTQLAQIRPLIFN---SSARSAMRDCL 191

  Fly   952 DHLRNKGRLQ--REWEALCRYEAE----PSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANA 1010
            :.|:.|..|.  ||:     .|.|    |....:.:..|....||....||||.:||.|     .
Mouse   192 NTLQKKEELDIIREF-----LELEQMTLPDDFNSGNTLQNRDKNRYRDILPYDSTRVPL-----G 246

  Fly  1011 EGLDYVNAS--TITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACAR 1073
            :..||:|||  .|.:|:... .|:|.|||||.|:..||||:.|....||..:.|..|.|.:.|..
Mouse   247 KNKDYINASYIRIVNHEEEY-FYIATQGPLPETIEDFWQMVLENNCNVIAMITREIECGVIKCYS 310

  Fly  1074 YWP---EEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQA 1135
            |||   :|..|..| :.|.|.:.|: ...:.||.|.:....|.:::.|....|..||..|.||.|
Mouse   311 YWPISLKEPLEFEH-FSVFLETFHV-TQYFTVRVFQIVKKSTGKSQCVKHLQFTKWPDHGTPASA 373

  Fly  1136 KALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQ 1200
            ...:.:.|.|.||:   .:.|::||.|||.|||||:|.:|:|...:.|. ...||...:..:|.|
Mouse   374 DFFIKYVRYVRKSH---ITGPLLVHCSAGVGRTGVFICVDVVFSAIEKN-YSFDIMNIVTQMRKQ 434

  Fly  1201 RAGVVATRQQFEFVLMAVAEEVHAIL 1226
            |.|::.|::|::|....|.|.:..:|
Mouse   435 RCGMIQTKEQYQFCYEIVLEVLQNLL 460

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293
		PTP_DSP_cys	942..1225	CDD:475123	95/293 (32%)
Ptpn20	XP_006518791.1	PTP_DSP_cys	251..457	CDD:475123	76/212 (36%)