Protein Alignment IA-2 and ZK354.8

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_500775.1
• Gene: ZK354.8 / 191295
• WormBaseID: WBGene00022709
• Length: 483
• Species: Caenorhabditis elegans
• Alignment Length: 325
• Identity: 82/325 - (25%)
• Similarity: 127/325 - (39%)
• Gaps: 83/325 - (25%)

  Fly   908 ITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEA 972
            :..|.||....|          :|.|.    ||:|     |::.:..||:.|
 Worm   198 VAGLKKEYRDSP----------NEAPE----DIAT-----SFLGNPTRNRYR------------- 230

  Fly   973 EPSAREAASQPQCAGLNRPGAPLPYDHSRVVLN---HLANAEGLDYVNASTITDHDPRAPAYVAA 1034
                    :.|.|            |.:||.|.   |.       |::|:.::. .|....::..
 Worm   231 --------NIPCC------------DITRVKLTDDPHF-------YIHANLVSS-GPNPRRFICT 267

  Fly  1035 QGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDD 1099
            |.||..|:..||:||...|...||.||.|.|.|:...|.|:|.:..:...|..:..|::....|
 Worm   268 QAPLNGTIEEFWKMIIVTGIEYIVMLCELVEKGKPKSAEYFPSQIGQTTKIGRLCTVTKESRVD- 331

  Fly  1100 YLVRSFYLKNLRTSE------TRTVTQFHFLSWPHMGVPAQAKA---LLDFRRKVNKSYRGRRSC 1155
             :.::..:..:|.|:      .:.|...|:.:||..|||....:   ||...:...|
 Worm   332 -IDKTLVMSTMRISKPGDNAVVKIVKHIHWRNWPDHGVPDNFLSPFRLLTVVKNCTK-------- 387

  Fly  1156 PIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE 1220
            |||||.|||.||||...|:.::||.:.. ...|.:...|..||::|...|.|..|:.:....|.|
 Worm   388 PIVVHCSAGVGRTGTLALILIILESICL-PDFIGVPRLLAKLREERFRAVQTEMQYLYAHRCVLE 451

  Fly  1221  1220
             Worm   452  451

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293
		PTP_DSP_cys	942..1225	CDD:475123	74/291 (25%)
ZK354.8	NP_500775.1	PTPc	200..451	CDD:214550	81/321 (25%)