Protein Alignment IA-2 and M04G7.2

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_499934.1
• Gene: M04G7.2 / 187449
• WormBaseID: WBGene00019773
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 685
• Identity: 147/685 - (21%)
• Similarity: 236/685 - (34%)
• Gaps: 217/685 - (31%)

  Fly   575 NSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLL 639
            |.|.|:||                ::.|...:|.......:|...|... ...:|.:|||
 Worm     2 NMFNRKAK----------------QEVTKKPEASNGSKNSKSTFVNSKS-PNQKRREVKK----- 44

  Fly   640 GPPSLGSAELSNQLETEKAHKQKGHGNKEVLPA---HIKGNDEDDAHKKKKVMKQQHSAEDHAPH 701
                       :..:||.:||.........:||   :.||::|  .||:|.|.:......:|.|.
 Worm    45 -----------SDSDTESSHKNTRRTKPVPVPAASSNSKGSNE--KHKRKSVQQVVKKVVNHIPF 96

  Fly   702 TVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTAGDV 766
            :...:....... |:...|..:..|.::.           :...:.|:...|....|
 Worm    97 SPSKQPKSTSTP-PVSEGNRKRLAMADVS-----------INQLESEMDSFVKKIEP-------- 141

  Fly   767 ARTINENRGVK----NNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMF 827
                ||.|..:    |::.|                  .:.:|....::.::|..| .|:
 Worm   142 ----NERRATQYIHSNSLSR------------------SNEAVPPGNVKTSQQKAD-HHL----- 178

  Fly   828 AGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTG 892
                      |..|..||               |:.| || ...|.:..:|
 Worm   179 ----------IRTTRSLI---------------GLDG-ET-EAVYSKATKA-------------- 202

  Fly   893 GAAGGGSNEPAP-SGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRN 956
                      :| .|::|:.|       ||||.::.|..|..:.|..|      .:|..:|.
 Worm   203 ----------SPDKGKLTADS-------PSSRRTSKSLEENSSETTND------SISLADDE--- 241

  Fly   957 KGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAP---------------------LP-YDH 999
              ..:..:..|.:..|..|.:......:....|.||.|                     :| .|.
 Worm   242 --ETREAYRKLFKDFAMSSQKMTLDDFKQEFSNLPGDPPSDLCTVFNHPVNNKKNRYSNIPCLDI 304

  Fly  1000 SRVVLN-HLANAEGLDYVNASTITDHDPRAP----AYVAAQGPLPSTLAHFWQMIWEQGAVVIVA 1059
            |||.|. .:.|....||::|:.|     |:|    .|:..|||...|.|.||:|||::....||.
 Worm   305 SRVQLKFKMPNKNSTDYIHANYI-----RSPFLKRGYILTQGPKKETRADFWRMIWQENTTAIVM 364

  Fly  1060 LCRLQENGEVACARYWPEEG-----AEVYHI-YEVHLVSEHIWCDDYLVRSFYLKNLRTS---ET 1115
            ||:..|.....||.|:|...     .:.:.: ||          |..:.:|.....|..|   ||
 Worm   365 LCQFLETNREKCAEYFPRNAHCCLQFDKFSVNYE----------DSTVNKSLVTTRLNLSYEGET 419

  Fly  1116 RTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLER 1180
            |.:|.:.:..||...||..::.:|...||:.     .||.|.|:|.|||.||:|..:.:::.|:.
 Worm   420 RLITHWLWKEWPDWQVPESSEVMLKILRKIR-----ARSTPPVIHCSAGVGRSGTLMAVEIALQS 479

  Fly  1181 MNKGAREIDIAATLEHLR-DQRAGVVATRQQFEFV 1214
            ::......||...:.||| ..||..|.|.||:..:
 Worm   480 IHTHFTLPDIKQIVSHLRVTGRAASVQTLQQYMLI 514

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	11/93 (12%)
		PTP_DSP_cys	942..1225	CDD:475123	82/310 (26%)
M04G7.2	NP_499934.1	PTZ00108	<9..242	CDD:240271	63/384 (16%)
		PTPc	266..520	CDD:214550	77/269 (29%)