DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment IA-2 and F20H11.4

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	NP_498458.1	Gene:	F20H11.4 / 175937	WormBaseID:	WBGene00017647	Length:	446	Species:	Caenorhabditis elegans

Alignment Length:	415	Identity:	107/415 - (25%)
Similarity:	187/415 - (45%)	Gaps:	73/415 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly   910 SLSKENEGRPP------SSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALC 968
            |.:::::.:||      :::....:|                   :..|.|..| :|.|::.||
Worm    85 SKNRKSKMKPPPDTQELANKKKFCNW-------------------FFVDELDCK-KLMRDFVAL- 128

  Fly   969 RYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVA 1033
               ..||...|.:..:.:...|....|..|.:||||.:  .....|:::|:.:|  .|....|::
Worm   129 ---RAPSTCVADTMKKHSEKCRYYDILCPDATRVVLQN--RPPDNDFIHANWMT--MPDKFRYIS 186

  Fly  1034 AQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEG--AEVYHIYEVHLVSEHIW 1096
            ||||:..|:..||.|::.:.|..:|.:|..:|:|...|:||.|.|.  :.|..||.:..:.:...
Worm   187 AQGPMDQTVEDFWHMVYTEKAPAVVMICDWEEDGIQKCSRYIPSEDNISHVCGIYRITKIDQMTM 251

  Fly  1097 C-DDYLVRSFYL----KNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRG-RRSC 1155
            . .|..::||.:    |:|. ..:..|..:|||.|.....|..:.::|    |:.|:.|. :|..
Worm   252 VYADVALQSFEISVTDKSLE-CPSLVVKHYHFLKWRDHTAPMTSISVL----KLLKALRDPKRPG 311

  Fly  1156 PIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE 1220
            |.|:|.|||.|||...|.:|...:|:.: ..|:::...:..:|..|...|.:..||.|:||.:|:
Worm   312 PPVIHCSAGIGRTATLIGVDYGNQRIGE-VGEMNVLDIVREMRQMRDKAVQSHHQFIFMLMCIAD 375

  Fly  1221 EVHAILKALPANTSGEKRELDKDPVVGGGSSSTT-TKEPLKEDKAQEAAEEEAPTSSSKAAAAAK 1284
            .:  :|..:|.|          |.::......|. .|:.|.|.|.::.||:            ||
Worm   376 RM--VLDGVPQN----------DNMLDLADFYTEFMKKVLMERKKKDEAEK------------AK 416

  Fly  1285 KEKEKDKDKEEKQAKDQAKVAEPRT 1309
            ||||:.:.::|...|...|.|..:|
Worm   417 KEKEEKRKRDEANDKTNEKSALSKT 441

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410
		PTPc	960..1220	CDD:214550	77/267 (29%)
		PTPc	995..1220	CDD:238006	69/232 (30%)
F20H11.4	NP_498458.1	Y_phosphatase	142..375	CDD:278528	70/242 (29%)
F20H11.4	NP_498458.1	PTPc	144..375	CDD:238006	70/240 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S3974
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.860