Protein Alignment IA-2 and ptp-3

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001263671.1
• Gene: ptp-3 / 174685
• WormBaseID: WBGene00004215
• Length: 2248
• Species: Caenorhabditis elegans
• Alignment Length: 1225
• Identity: 256/1225 - (20%)
• Similarity: 447/1225 - (36%)
• Gaps: 333/1225 - (27%)

  Fly   187 PHSEVCYDDNIFG----------KCIPTTGVDVE--DIEKTPLTEDQSRVLA------------- 226
            |::|..:..|.|.          |.|.|.|:..|  :|....|..|:..|:|
 Worm   891 PNTEYSFRLNAFNRNGDGEFSERKSIITQGIPPEAPEIVSVSLDRDEPPVVARIEWKMPKMKPNE 955

  Fly   227 TMLEE--LQGAGLGWDHPYVQCR-IQGS-----------------LFSLQRQQQLPPNLCANLA- 270
            |.:|:  |.....|:...||:.: :.|:                 |.:.:.::....|....:|
 Worm   956 TPIEKYNLWLRAQGYPDSYVKAKTVDGTDLSTTISGLWMGVVYDVLLAAENREGRSQNATETIAT 1020

  Fly   271 PTPPEFGDPASALAY--------VRFTPPEPE-----------------AELDYYEQPAGPAQFY 310
            |.....|:|.. :.|        |.:.||..|                 |..|.||||.
 Worm  1021 PVGSPDGEPID-VQYEVMKGKIVVSWRPPSEEKRNGNITSYKAILSAMDATADRYEQPV------ 1078

  Fly   311 PALRKKQVRESDADDMYLNRMLQDRRR----------LRHDPSELEHFGKMDGHGQSTQLDAPSI 365
            ||.......|.:....||.::.....:          :..||:.|.      |...:.:::|.|.
 Worm  1079 PAPSTSSTFEVNVRRAYLFKVAAATMKGIGPYSPVLTINPDPAALV------GPPTNVRVEATSN 1137

  Fly   366 MDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDP------------QPY--- 415
            ..|.:..:.:..:.:..:.....:...|.:..:.:...:::..:.:|            :||
 Worm  1138 STAVVQWDFESQKADSFVVKYMHEPGNRMDTEKWKQLPVVSIDKENPKRFAVVSDLNAHKPYAFC 1202

  Fly   416 -------QRKPAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAP 473
                   ::.|.:.|..:  ||::......:.|:        .::.....|..:.|...|.|...
 Worm  1203 VLAVKNNRQGPCSDPPTV--LESVTPTYMVQNLR--------VLWKTSNSVQLTWEYNGPRNVGF 1257

  Fly   474 FKRARGR-------------SRGGLAEEVEDEQPKRSFFRELAGEQ------GLVQEPPLRFRH- 518
            :....||             |..|..::| ||:.:...:..|....      |:...||...::
 Worm  1258 YVNHTGRKDYVNHELQEKTMSTPGFGQDV-DEKHREYLWTNLRPHMMYTIHVGVRTLPPGARKYW 1321

  Fly   519 ---VETEVDAT-PELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPR 579
               |.|..|.| |..|             ||.........:.|.....|||..||....|:.:
 Worm  1322 PQEVVTITDPTGPPFV-------------DVPKLVDSSGTQPGQQMIRLTPATEEYGPISHYW-- 1371

  Fly   580 QAKSQRVYTEGGLLLMP-----QDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLL 639
                        ::|:|     :|..:.|.::.::....|::.||..|..:..::|..|
 Worm  1372 ------------IILVPANYSTEDVVNLDPIELEKATAEKRAQLARSLSVSPSKKLKRK------ 1418

  Fly   640 GPPSLGSAELSNQLETEKAHKQKGHGNKEVLP-AHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTV 703
                  ::|:.:..::...|.::....:..:| |::......|.      :|||:  .::.|..|
 Worm  1419 ------ASEVGDDSQSASYHPKEKRARRATVPGAYVTARLSADR------VKQQY--RNNQPFIV 1469

  Fly   704 -DTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNNPERKTAGDVA 767
             |::....|...|             ||..||            :.:..|..:.|..|
 Worm  1470 GDSQLYDGFTNYP-------------LEHNLH------------YRLMMRAFAKNDVR------- 1502

  Fly   768 RTINENRGVKNNIQRRVGFYVLHAGVGDVIKD--LQDPSVSSSRIELAEQGPDVTHIMAYMFAGA 830
                    .|::.::|.   .:...:..:..|  |.:|....|.:..|.|       .:..:.||
 Worm  1503 --------TKDSFEQRA---PMSEKLSRMYSDSVLTEPFTIKSALRGASQ-------KSSPWVGA 1549

  Fly   831 GAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGN-----S 890
             ..|.:|:|                     .|.|...|   :...|..:.||:....|:     .
 Worm  1550 -CIAFLVLF---------------------SIVGMLIC---WWLRCNKKSAGRHPRHGSITKVAL 1589

  Fly   891 TGGAAGGGSNEPAPSGRITSLSKENEGRP-----------------------PSSRSSTSSWSEE 932
            ||....||...|..:.::.|.|.| .||.                       |:|.|.::.::..
 Worm  1590 TGNIMNGGGGIPGETSKLLSTSNE-YGRQIMNPYEQMNGNHHMESSMDLYPLPTSHSRSNGYAPV 1653

  Fly   933 PAL--------TNM-DISTGHMVLSYMEDH-----LRNKGRLQREWEALCRYEAEPSAREAASQP 983
            |..        .|| .:|...:.::.:.:|     :.|....|.|:|::  ...:....|.:|..
 Worm  1654 PVAIPSLPNNGNNMTTVSHPAVPIAELANHIERLRMNNNAGFQSEFESI--ETGQHFTWEHSSAD 1716

  Fly   984 QCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHD-PRAPAYVAAQGPLPSTLAHFWQ 1047
            .....||......||||||||:::....|:||:||:.:..:| ||  :|:|.|||||.|.:.||:
 Worm  1717 MNKHKNRYANVAAYDHSRVVLSNVEGYPGMDYINANYVDGYDKPR--SYIATQGPLPETFSDFWR 1779

  Fly  1048 MIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRT 1112
            |:||:.:|.||.|..|:|...|.|.:|||..|...|...||.|: |.:....|.:|:..||.:..
 Worm  1780 MVWEEQSVTIVMLTNLEERSRVKCDQYWPSRGTATYGDIEVTLL-ESVHLAHYTMRTMRLKMVGE 1843

  Fly  1113 SETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLV 1177
            .|.|.:....:.:||..|||......|.|.::| |:.....:.||:.|.|||.||||.:|::|.:
 Worm  1844 PEVREIKHLQYTAWPDHGVPDHPTPFLIFLKRV-KTLNPNDAGPIISHCSAGIGRTGAFIVIDCM 1907

  Fly  1178 LERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPAN 1232
            |||: :....:||...:..||.||:.:|.|.:|:.|:..||.:.|::....:||:
 Worm  1908 LERL-RYDNTVDIYGCVTALRAQRSYMVQTEEQYIFIHDAVLDAVNSGSTEVPAS 1961

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	11/89 (12%)
		PTP_DSP_cys	942..1225	CDD:475123	98/288 (34%)
ptp-3	NP_001263671.1	Ig	93..185	CDD:472250
		Ig strand B	109..113	CDD:409353
		Ig strand C	122..126	CDD:409353
		Ig strand E	146..152	CDD:409353
		Ig strand F	163..168	CDD:409353
		Ig strand G	177..180	CDD:409353
		Ig	197..288	CDD:472250
		Ig strand B	212..216	CDD:409353
		Ig strand C	225..229	CDD:409353
		Ig strand E	252..256	CDD:409353
		Ig strand F	266..271	CDD:409353
		Ig strand G	278..281	CDD:409353
		Ig	309..380	CDD:472250
		Ig strand B	312..316	CDD:409353
		Ig strand C	325..329	CDD:409353
		Ig strand E	347..351	CDD:409353
		Ig strand F	359..364	CDD:409353
		Ig strand G	372..375	CDD:409353
		FN3	383..499	CDD:238020
		FN3	449..932	CDD:442628	10/40 (25%)
		FN3	<769..1140	CDD:442628	49/261 (19%)
		fn3	1125..1213	CDD:394996	8/87 (9%)
		R-PTPc-LAR-1	1716..1953	CDD:350401	91/241 (38%)
		R-PTP-LAR-2	2001..2238	CDD:350402