Protein Alignment IA-2 and ptprsa

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_068072483.1
• Gene: ptprsa / 140820
• ZFINID: ZDB-GENE-020107-3
• Length: 1936
• Species: Danio rerio
• Alignment Length: 1143
• Identity: 248/1143 - (21%)
• Similarity: 410/1143 - (35%)
• Gaps: 317/1143 - (27%)

  Fly   246 CRIQGSLFSLQRQQQLPPNLC---------------ANLAPTPPEFGDPASALAYVRFTPPEPEA 295
            |.:|.|        .|||.|.               |.....|.|...||...:|: .....|.|
Zfish   933 CSVQFS--------WLPPVLAERNGAITEYTLSYQEAGTISGPKELRLPADENSYI-LNSLRPNA 988

  Fly   296 ELDY---YEQPAGPAQFYPALRKKQVR-ESDADDMYLNRMLQDRRRL---RHDPSELEHFGKMDG 353
            ..|.   .....||..:.|.::.:.|. |:|....:..:::.....|   :...|...:...::.
Zfish   989 VYDVKIRAHTSVGPGPYSPPIQYRTVAYEADVPRNFTVKLVTKTTVLLSWKFYDSRFPYKCTIEY 1053

  Fly   354 HGQSTQLDAPSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRK 418
            |.|.:.:|| .:....:...|.....|.:::.  ||:.....:::|     :|.:.|..|  .||
Zfish  1054 HRQKSDIDA-RMTKTLITNLRPNTTYEFRISC--QDSSDGGPKHKL-----VARTAPHIQ--IRK 1108

  Fly   419 PAAQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRG 483
            |                  :.:||.:.|.....|:.|.|..:....:|..  ..|.|:.:|..|
Zfish  1109 P------------------ELDLKRESESTLTIVFPPLETKDLIKAIYVV--VVPLKKGKGPMR- 1152

  Fly   484 GLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVET-----EVDATPELVKRRP---ASFKQL 540
                  ..:.|......||.||:      .|...|..|     :||.      :||   ||||..
Zfish  1153 ------HIKSPDELDLEELLGER------RLGLHHSGTTRQLKQVDG------KRPYIAASFKPS 1199

  Fly   541 D-PYDVSLQQQEM--AFESGLLRNS-------LTPLEEEAMLASNSFPRQAKSQRVYTE------ 589
            . |...:|..|.|  :||:..|...       |..|....:.|..|.|        ||:
Zfish  1200 SMPPSFTLGNQMMYGSFENRALDRGQEYVLFILAELNTTGVKAFVSSP--------YTDPIMAPD 1256

  Fly   590 --------GG----------------------LLLMPQDEQDTDGMQADEPENVKQSLLANMLGF 624
                    ||                      :||....:.|:...:..||   :...|.|....
Zfish  1257 LDPQPLESGGDGLIWVVGPVLAVVFIICIVIAILLYKNSKPDSSKRKESEP---RTKCLLNNADI 1318

  Fly   625 ARHERLD-------------------VKKPG----PLLGPPSLGSAELSNQLETEKAHKQK---- 662
            ..|...|                   |.:.|    .::..|.:..:||:...|..||:...
Zfish  1319 TPHHPTDPVEMRRINFQTPDSGLSSPVSEAGFDYESMMNHPPIPISELAEHTELLKANDNLKLSQ 1383

  Fly   663 -------------GHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAP-------HTVDTEY 707
                         .|.|.||         ....::...|:...||....||       ..:::.|
Zfish  1384 EYESIDPGQQFTWEHSNLEV---------NKPKNRYANVIAYDHSRVILAPIEGITGSDYINSNY 1439

  Fly   708 V--------HVFVKNPI-DSWNDGQRIMKELEQILHMQGYFSYLTVQQHEVSFRVNSNN--PERK 761
            :        ::..:.|: :::.|..|::.|       |...:.:.:.:.|...|:..:.  |.|.
Zfish  1440 IDGYRKQNAYIATQGPLPETFGDFWRMVWE-------QRAATVVMMTRLEEKSRIKCDQYWPSRG 1497

  Fly   762 T----------------AGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIKDLQDPSVSSSRI 810
            |                |....||.:.::...:. :|.|..:...|.....:.:...|.::..|.
Zfish  1498 TETYGMIQVTLLDTIELATFCVRTFSLHKNGSSE-KREVRQFQFTAWPDHGVPEYPTPFLAFLRR 1561

  Fly   811 ELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRHDRKRDKLGGLQSGIAGAETCSKDYQEL 875
            ......||...|:|:..||.|.....::...::...:|::..|..|               :..|
Zfish  1562 VKTCNPPDAGPIIAHCSAGVGRTGCFIVIDAMLERIKHEKTVDIYG---------------HVTL 1611

  Fly   876 CRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWS-------EEP 933
            .|                           |.|...:..|::            :|       |..
Zfish  1612 MR---------------------------SQRNYMVQTEDQ------------YSFIHDALLEAV 1637

  Fly   934 ALTNMDISTGHMVLSYME--------DHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNR 990
            |..|.::: ...:.||::        :|:..   ::.|::.|...:|..|...:|:.|.....||
Zfish  1638 ACGNTEVA-ARSLFSYIQKLAQVEAGEHVSG---MELEFKRLANSKAHTSRFISANLPCNKFKNR 1698

  Fly   991 PGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAV 1055
            ....:||:.:||.|..:...||.||:|:|.| |...:..||:|.||||..|...||:|:||..:.
Zfish  1699 LVNIMPYETTRVCLQPIRGLEGSDYINSSFI-DGYRQQKAYIATQGPLAETTEDFWRMLWENNST 1762

  Fly  1056 VIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQ 1120
            ::|.|.:|:|.|...|.:|||.|.:..|..:.|..::|:. ...|::|.|.:.:.|..::|||.|
Zfish  1763 IVVMLTKLREMGREKCHQYWPAERSARYQYFVVDPMAEYN-MPQYILREFKVTDARDGQSRTVRQ 1826

  Fly  1121 FHFLSWPHMGVPAQAKALLDFRRKVNKSYR--GRRSCPIVVHGSAGAGRTGVYILLDLVLERMN- 1182
            |.|..||..|||...:..:||..:|:|:..  |:.. ||.||.|||.|||||:|.|.:|||||.
Zfish  1827 FQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG-PISVHCSAGVGRTGVFITLSIVLERMRY 1890

  Fly  1183 KGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAE 1220
            :|.  :||..|::.||.||..:|.|..:::|...|..|
Zfish  1891 EGV--VDIFQTVKMLRTQRPAMVQTEDEYQFCYQAALE 1926

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	17/116 (15%)
		PTP_DSP_cys	942..1225	CDD:475123	102/290 (35%)
ptprsa	XP_068072483.1	I-set	31..122	CDD:400151
		Ig strand B	48..52	CDD:409353
		Ig strand C	61..65	CDD:409353
		Ig strand E	84..91	CDD:409353
		Ig strand F	102..107	CDD:409353
		Ig strand G	115..118	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	135..224	CDD:409400
		Ig strand A'	141..145	CDD:409400
		Ig strand B	148..157	CDD:409400
		Ig strand C	162..168	CDD:409400
		Ig strand C'	170..172	CDD:409400
		Ig strand D	181..185	CDD:409400
		Ig strand E	188..193	CDD:409400
		Ig strand F	202..209	CDD:409400
		Ig strand G	212..223	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	237..318	CDD:409401
		Ig strand A	237..239	CDD:409401
		Ig strand A'	243..247	CDD:409401
		Ig strand B	250..258	CDD:409401
		Ig strand C	263..269	CDD:409401
		Ig strand C'	271..273	CDD:409401
		Ig strand D	276..280	CDD:409401
		Ig strand E	285..290	CDD:409401
		Ig strand F	297..304	CDD:409401
		FN3	307..837	CDD:442628
		Ig strand G	308..317	CDD:409401
		FN3	792..>1088	CDD:442628	32/166 (19%)
		fn3	922..1006	CDD:394996	18/81 (22%)
		R-PTPc-S-1	1358..1639	CDD:350473	51/351 (15%)
		R-PTP-S-2	1641..1930	CDD:350475	103/295 (35%)