Protein Alignment IA-2 and ptprfa

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_068077727.1
• Gene: ptprfa / 140819
• ZFINID: ZDB-GENE-020107-2
• Length: 1910
• Species: Danio rerio
• Alignment Length: 797
• Identity: 191/797 - (23%)
• Similarity: 319/797 - (40%)
• Gaps: 214/797 - (26%)

  Fly   500 RELAGEQGLVQEPPLRFRHVETEVDATPELVK----------------RRPASFKQLDPYDVSLQ 548
            |...|:.|....|.::.|.:.|.:   ||..|                ..|.::|...|:.:...
Zfish   985 RAFTGKGGGPISPSIQSRTMSTSM---PEFTKNFGVKAVMKTSVLLTWEVPETYKSQVPFKILYN 1046

  Fly   549 QQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENV 613
            ||.:..:..|.|..:|.|:.:   ...||...::..   :.|||      :|......|.:....
Zfish  1047 QQSVEVQGDLKRKLITRLQPD---TDYSFVLMSRGN---SAGGL------QQQVSIRTAPDLFTT 1099

  Fly   614 KQSLLANMLGFARHERLDVKKPGPL----------------------LGPPSLGSAELSNQLETE 656
            |.:          |::||.::.|.|                      :.|.:|...|....::.:
Zfish  1100 KPA----------HQKLDPEEGGKLAITLPEVHNSALVRWFYIVVVPVTPSTLRHWENPEDIDLD 1154

  Fly   657 KAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVKNPIDSWND 721
            :                :.||:.|.|.::::...|              :::..::...::|
Zfish  1155 E----------------LMGNNRDAAVRRRRRQTQ--------------DFLRPYIAAKLES--- 1186

  Fly   722 GQRIMKELEQILHMQGYFSY----LTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQR 782
                :.|...:...:.|.:|    |..||...:| :.:...:|.:...|: ..:|...||
Zfish  1187 ----LPERFVLGDEKTYSNYYNKPLPGQQQYRTF-ILAALKDRDSTFTVS-PFSEPMMVK----- 1240

  Fly   783 RVGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKR 847
                  ||:|:...::|                 |::..:|..:.|   ...:|:|.:.::|.|
Zfish  1241 ------LHSGMSRHVED-----------------PEMLWVMGPVLA---VVLIIIIVIAILLFK- 1278

  Fly   848 HDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLS 912
              |||..........||.    ||:                      ....|::|....|   |:
Zfish  1279 --RKRTSPSAKDEHSAGV----KDH----------------------LLAHSSDPVEMRR---LN 1312

  Fly   913 KENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHL-----RNKGRLQREWEAL---CR 969
            .:.:|....:..|||...|.|.::          :..:.||:     .:..|..:|:|::   .:
Zfish  1313 YQTQGSSAFNCPSTSRMREHPPVS----------VCALADHIERLRANDSLRFSQEYESVDPGQQ 1367

  Fly   970 YEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAA 1034
            :..|.|..| .::|:    ||....:.||||||||..:....|.||:|.:.| |...:..||:|.
Zfish  1368 FTWENSNLE-VNKPK----NRYANVIAYDHSRVVLTPVDGVPGSDYINGNYI-DGYRKQNAYIAT 1426

  Fly  1035 QGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDD 1099
            |||||.||:.||:|:|||....||.:.||:|...|.|.:|||..|.|.|.:.:|.:: :.:....
Zfish  1427 QGPLPETLSDFWRMVWEQRTSTIVMMTRLEEKSRVKCDQYWPSRGTETYGMIQVSML-DTVELAT 1490

  Fly  1100 YLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSC------PIV 1158
            |.||:|.|....:||.|.|.||.|::||..|||.....:|.|.|:|       ::|      |:|
Zfish  1491 YSVRTFALYKNGSSEKREVRQFQFMAWPDHGVPEYPTPILAFLRRV-------KACNPPDAGPMV 1548

  Fly  1159 VHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVH 1223
            ||.|||.||||.:|::|.:|||| |..:.:||...:..:|.||..:|.|..|:.|:..|:.|
Zfish  1549 VHCSAGVGRTGCFIVIDAMLERM-KHEKSVDIYGHVTCMRSQRNYMVQTEDQYIFIHEALLE--- 1609

  Fly  1224 AILKALPANTSGEKREL 1240
               .|...||....|.|
Zfish  1610 ---AATCGNTEVPARSL 1623

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	16/93 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	106/296 (36%)
ptprfa	XP_068077727.1	Ig strand F	210..217	CDD:409400
		Ig strand G	220..231	CDD:409400
		IgI_3_RPTP_IIa_LAR_like	241..322	CDD:409401
		Ig strand A	241..243	CDD:409401
		Ig strand A'	247..251	CDD:409401
		Ig strand B	254..262	CDD:409401
		Ig strand C	267..273	CDD:409401
		Ig strand C'	275..277	CDD:409401
		Ig strand D	280..284	CDD:409401
		Ig strand E	289..294	CDD:409401
		FN3	299..735	CDD:442628
		Ig strand F	301..308	CDD:409401
		Ig strand G	312..321	CDD:409401
		FN3	716..812	CDD:238020
		FN3	817..898	CDD:238020
		FN3	915..1003	CDD:238020	4/17 (24%)
		FN3	1013..1082	CDD:238020	12/74 (16%)
		PTP_DSP_cys	1340..1613	CDD:475123	107/293 (37%)
		PTP_DSP_cys	1615..1905	CDD:475123	4/9 (44%)
		I-set	33..124	CDD:400151
		Ig strand B	50..54	CDD:409353
		Ig strand C	63..67	CDD:409353
		Ig strand E	86..93	CDD:409353
		Ig strand F	104..109	CDD:409353
		Ig strand G	117..120	CDD:409353
		IgI_2_RPTP_IIa_LAR_like	136..232	CDD:409400
		Ig strand A	136..138	CDD:409400
		Ig strand A'	143..147	CDD:409400
		Ig strand B	150..159	CDD:409400
		Ig strand C	164..170	CDD:409400
		Ig strand C'	172..174	CDD:409400
		Ig strand D	183..187	CDD:409400
		Ig strand E	196..201	CDD:409400