Protein Alignment IA-2 and Lar

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_061516302.1
• Gene: Lar / 1279520
• VectorBaseID: AGAMI1_014585
• Length: 2049
• Species: Anopheles gambiae
• Alignment Length: 1042
• Identity: 224/1042 - (21%)
• Similarity: 373/1042 - (35%)
• Gaps: 303/1042 - (29%)

  Fly   271 PTPPEFGDPASALAYVRFTPPEPEAELDYY---------------EQPAGPAQFYPALRKKQVRE 320
            ||...:..||......:...|:|..:.|:|               .:..||...|
Mosquito  1209 PTDYSYKPPAKITVTTQMAAPQPMVQPDFYGVVNGEEIQVILPQASEEYGPISHY---------- 1263

  Fly   321 SDADDMYLNRMLQDRRRLRHDPSELEHFGKMDGHGQSTQLDAPSIMDAFLDTERQRIEREQQLAA 385
                  ||..:.:|:..|...|.:......:....:..:|:||.|...||   ::.|.....|.:
Mosquito  1264 ------YLIVVPEDKANLHKIPDQFLTEELLPSRPKLDRLNAPYIAAMFL---QRNIPYTFHLGS 1319

  Fly   386 AEQD---ADRRAEQ-NRLELYQILAASEPDPQPYQRKPAAQPNAMDQLEAIVEQQQQRELKEQQE 446
            .|.:   .:::.|: .|..::.......|....|...|.::..|:|..||...:
Mosquito  1320 GETNHNFTNKKLERGKRYRIFVRAVVDTPQKHLYTSSPFSEFLALDMKEAPTGE----------- 1373

  Fly   447 QAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSRGGLAEEVEDEQPKRSFFRELAGEQGLVQE 511
                |.:.|...|.:.:|:..          ||::                            :|
Mosquito  1374 ----PPHRPNPNVPQDTEIII----------RGKN----------------------------EE 1396

  Fly   512 PPLRFRHVETEVDATPELVKRRPASFKQLDPYDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNS 576
            |.:.:        ....::.....|...|..|.|..::|
Mosquito  1397 PGMLW--------VVGPIIAALVLSVCFLVVYFVRRRRQ-------------------------- 1427

  Fly   577 FPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLLGP 641
             |.:|..|...|..   ||..|.  ..|....:|.:::              |::.:.||.:..|
Mosquito  1428 -PCKAPDQAAVTRP---LMAADL--GAGPAPTDPVDMR--------------RINFQTPGMISHP 1472

  Fly   642 PSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDA----------HKKKKVMKQQH--- 693
            | :..|||:|.:|..||:.            ::|.:.|.::          |...:|.|.::
Mosquito  1473 P-ISIAELANHVERLKAND------------NLKFSQEYESIEPGQQFTWDHSNMEVNKPKNRYA 1524

  Fly   694 --SAEDHA----------PHT--VDTEY--------VHVFVKNPI-DSWNDGQRIMKELEQILHM 735
              ::.||:          |.:  ::..|        .:|..:.|: :::.|..|:..||:
Mosquito  1525 NVTSYDHSRVILPPIEGVPGSDYINANYCDGYRKHNAYVATQGPLQETFGDFWRMCWELK----- 1584

  Fly   736 QGYFSYLTVQQHEVSFRVNSNNPERKTA--GDVARTINENRGVKNNIQRRVGFYVLHAGVGDVIK 798
            ......:|..:.....:.:...|.|.|.  |.:..||.|.:.:.....|....|...:.....||
Mosquito  1585 SSTIVMMTRLEERSRIKCDMYWPARGTEVYGAMTVTITETQELATYSIRTFQIYRNGSNERREIK 1649

  Fly   799 DLQ-----DPSV------------SSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIK 846
            .||     |..|            .:..:..:|.||.:.|..    ||.|.....::..:::...
Mosquito  1650 QLQFTAWPDHGVPDHPAPFLQFLRRTKSLTPSESGPIIVHCS----AGVGRTGCYIVIDSMLERM 1710

  Fly   847 RHDRKRDKLGGLQSGIAGAETC----------SKD-----YQELCRARMAGKAGGGGNSTGGAAG 896
            ::::..|        |.|..||          ::|     :..|..|.:.|.
Mosquito  1711 KYEKTID--------IYGHVTCLRAQRNYMVQTEDQYIFIHDALLEAVICGS------------- 1754

  Fly   897 GGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQ 961
                                             :|.||   ..:......|...|.| .|...::
Mosquito  1755 ---------------------------------TEVPA---RSLHNHIQKLMQTEPH-ENITGME 1782

  Fly   962 REWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDP 1026
            .|::.|...:|:.:....|:.|.....||....|||:.|||.|..:...||.||:|||.:..:..
Mosquito  1783 MEYKKLSNVKADSTRFVTANLPCNKHKNRLVHILPYESSRVCLTPIRGVEGSDYINASLVDGYRY 1847

  Fly  1027 RAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLV 1091
            | .||:||||||..|...||:|:||..:.::|.|.:|:|.|...|.:|||.|.:..|..|.|..:
Mosquito  1848 R-NAYIAAQGPLQETAEDFWRMLWEHNSTIVVMLTKLKEMGREKCFQYWPHERSVRYQCYVVDPI 1911

  Fly  1092 SEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYR--GRRS 1154
            :|:. ...|.:|.|.:.:.|...:|||.||.|:.||..|||...:..:||..:|:|:..  |:..
Mosquito  1912 AEYN-MPQYKLREFKVTDARDGSSRTVRQFQFIDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG 1975

  Fly  1155 CPIVVHGSAGAGRTGVYILLDLVLERMN-KGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAV 1218
             ||.||.|||.|||||:|.|.:|||||. :|.  :|:..|:..||.||..:|.|..|::|...|.
Mosquito  1976 -PITVHCSAGVGRTGVFITLSIVLERMQYEGV--LDVFQTVRILRSQRPAMVQTEDQYQFCYRAA 2037

  Fly  1219 AE 1220
            .|
Mosquito  2038 LE 2039

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	17/100 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	106/282 (38%)
Lar	XP_061516302.1	None