DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment IA-2 and Ptprn

DIOPT Version :9

Sequence 1:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster
Sequence 2:	XP_017451718.1	Gene:	Ptprn / 116660	RGDID:	620777	Length:	1064	Species:	Rattus norvegicus

Alignment Length:	1103	Identity:	382/1103 - (34%)
Similarity:	522/1103 - (47%)	Gaps:	213/1103 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   177 GCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTPLTEDQSRVLATM---LEELQGAGLG 238
            ||.|.|.|| .|.|||..|.:||:|....|      :..||.:..|.||..:   |.:|...||.
  Rat   125 GCLFDRRLC-SHLEVCIQDGLFGQCQAGVG------QARPLLQVTSPVLQRLQGVLRQLMSQGLS 182

  Fly   239 WDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPPE---PEAELDYY 300
            |.....|..|.      |..:::|     .|.|..|...|.:.::       |.   |..||...
  Rat   183 WHDDLTQYVIS------QEMERIP-----RLRPPEPHPRDRSGSV-------PRRAGPAGELLSQ 229

  Fly   301 EQPAGPAQFYPALRKKQVRESDADDMYLNRMLQDRRRLRHD--PSELEH--FGKMDGHGQSTQLD 361
            ..|.|.:   ||::.......|.:...:...|..   |:.:  |..|||  ......|...|.
  Rat   230 GNPTGSS---PAVQGLSRPPGDGNGAGVGSPLSS---LQAELLPPLLEHLLMPPQPPHPSLTY-- 286

  Fly   362 APSIMDAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRKPAAQPNAM 426
            .|:::..:|         .||..:  :|..|.:| :...:...||.:| ||..:.|..:
  Rat   287 EPALLQPYL---------FQQFGS--RDGSRGSE-SASGVVGHLAKAE-DPVLFSRSLS------ 332

  Fly   427 DQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRAR--------GRSRG 483
               :||:.........:....:.|.::      .:|..||.........|||        |.||.
  Rat   333 ---KAILGTHSGHSFGDLTGPSPAQLF------QDSGLLYMAQELPVPGRARAPRLPEEGGSSRA 388

  Fly   484 GLAEEVEDEQPKRSFFRELAGEQGLVQEPPLRFRHVETEVDATPELVKRRPASFKQLDP----YD 544
            ..:.|..:|        |:.|..|  ::.|             |:.|:....|.::|..    |.
  Rat   389 EDSSEGHEE--------EVLGGHG--EKSP-------------PQAVQAADVSLQRLAAVLAGYG 430

  Fly   545 VSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADE 609
            |.|:|             |||.:...:|..                 |.|:|:......|...:.
  Rat   431 VELRQ-------------LTPEQLSTLLTL-----------------LQLLPKGTGRHLGGAVNG 465

  Fly   610 PENVKQSLLANMLGFARHERLDVKKPGPLL-GPPSLGSAELS-NQLET----EKAHKQKGHGNKE 668
            ..:||:::...|   .|.:..|.:.|.||| |.|:..|..:. .|:.:    |........|...
  Rat   466 GADVKKTIEEQM---QRGDTADARPPTPLLPGHPTASSTSIKVRQVLSPGFPEPPKTSSPLGISA 527

  Fly   669 VLPAHIKGNDEDDAHKKKKVMKQ-------QHSAEDHAPHTVDTEYVHVFVKNPIDSWNDGQRIM 726
            ||            .:||..:.|       |.||...|     .||.::.......|...|.:::
  Rat   528 VL------------LEKKSPLGQSQPTVVGQPSARPSA-----EEYGYIVTDQKPLSLVAGVKLL 575

  Fly   727 KELEQILHM-QGYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRG-VKNNIQRRVGFYVL 789
            :.|.:.:|| .|.|..::|....|:||:..|......|     .:.:..| ||:.::.:.|..:|
  Rat   576 EILAEHVHMTSGSFINISVVGPAVTFRIRHNEQNLSLA-----DVTQQAGLVKSELEAQTGLQIL 635

  Fly   790 HAGVGDVIKDLQDPSVSSSRIELAEQGPDVTH-------IMAYMFAGAGAAAVIVIFVTLILIKR 847
            ..|||             .|.|.|...|...|       ::..:.|.||.|.::|.....:.::.
  Rat   636 QTGVG-------------QREESAAVLPRQAHGISPMRSLLLTLVALAGVAGLLVALAVALCMRH 687

  Fly   848 HDRKRDK--LGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITS 910
            |.::|||  |..|....|..:| :.:||:|||..||.|      |....|.|   :|.|| |::|
  Rat   688 HSKQRDKERLAALGPEGAHGDT-TFEYQDLCRQHMATK------SLFNRAEG---QPEPS-RVSS 741

  Fly   911 LSKENEG---RPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQREWEALCRYEA 972
            :|.:...   ..|||.|||.||.||||..|||||||||:|:||||||||:.||.:||:|||.|:|
  Rat   742 VSSQFSDAAQASPSSHSSTPSWCEEPAQANMDISTGHMILAYMEDHLRNRDRLAKEWQALCAYQA 806

  Fly   973 EPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGP 1037
            ||:....|........||....|||||:|:.|...::....||:|||.|.:||||.|||:|.|||
  Rat   807 EPNTCATAQGEGNIKKNRHPDFLPYDHARIKLKVESSPSRSDYINASPIIEHDPRMPAYIATQGP 871

  Fly  1038 LPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLV 1102
            |..|:|.||||:||.|..|||.|..|.|:|...|.||||:||:.:||:|||:||||||||:|:||
  Rat   872 LSHTIADFWQMVWESGCTVIVMLTPLVEDGVKQCDRYWPDEGSSLYHVYEVNLVSEHIWCEDFLV 936

  Fly  1103 RSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGR 1167
            |||||||::|.||||:|||||||||..|.||..:.||||||||||.||| |||||:||.|.||||
  Rat   937 RSFYLKNVQTQETRTLTQFHFLSWPAEGTPASTRPLLDFRRKVNKCYRG-RSCPIIVHCSDGAGR 1000

  Fly  1168 TGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALP 1230
            ||.|||:|:||.||.||.:||||||||||:||||.|:|.::.||||.|.||||||:|||||||
  Rat  1001 TGTYILIDMVLNRMAKGVKEIDIAATLEHVRDQRPGLVRSKDQFEFALTAVAEEVNAILKALP 1063

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	20/88 (23%)
		PTPc	960..1220	CDD:214550	161/259 (62%)
		PTPc	995..1220	CDD:238006	148/224 (66%)
Ptprn	XP_017451718.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	329	1.000	Domainoid score	I1123
eggNOG	1	0.900	-	-		E2759_KOG0793
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1214
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281324at33208
OrthoFinder	1	1.000	-	-		FOG0002390
OrthoInspector	1	1.000	-	-		otm46407
orthoMCL	1	0.900	-	-		OOG6_105521
Panther	1	1.100	-	-	LDO	PTHR46106
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1583
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	13	12.830