Protein Alignment IA-2 and ptprr

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_073804489.1
• Gene: ptprr / 100526652
• ZFINID: ZDB-GENE-101029-2
• Length: 639
• Species: Danio rerio
• Alignment Length: 743
• Identity: 179/743 - (24%)
• Similarity: 276/743 - (37%)
• Gaps: 211/743 - (28%)

  Fly   571 MLASNSFPRQAKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKP 635
            |||:.:....:...|::..||:      ..|.|..|..                  |.||...|.
Zfish     2 MLANAALLLISSLMRLHVTGGI------SADDDVFQTP------------------HRRLANGKI 42

  Fly   636 GPLLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVM----------- 689
            |.:.  ..:|:      |..|||...||    |.|||..:|       :..|:|
Zfish    43 GSVY--QQMGA------LIREKAVGFKG----EFLPARPRG-------RVAKLMPGVFLQSHFQR 88

  Fly   690 KQQHSAE-----DHAPHTVDTEYVHVFVKNPIDSWNDGQRIMKELEQILHMQGYFSYL---TVQQ 746
            ..|..||     |||.:           |.|...    ...|:|.::|   :.|.|.:   ....
Zfish    89 APQRQAELLRNTDHAEN-----------KQPAHR----TLTMEEKDEI---ELYVSSVGGSDPAA 135

  Fly   747 HEVSFRV-------NSNNPERKTAGDVARTINENRGVKNNIQRRVGFYVLHAGVGDVI------- 797
            ||...|:       :|:.|...|.....:.:.::...||.|..:.|||||      ||
Zfish   136 HEEMIRLLNLDNLQHSSGPIATTEASTEKNVFKDHHEKNGIWGKDGFYVL------VICLTIFLI 194

  Fly   798 ------------------KDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLIL 844
                              :.|:|||..|..:.||   |...|         ||...:.:..:::.
Zfish   195 IFSCLMVLYRLKEKEVLDQQLKDPSPPSRDVHLA---PVPVH---------GAQPPLTLKNSMVQ 247

  Fly   845 IKRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTGGAAGGGSNEP-APSG-- 906
            ..|..:..   .........|.:|:....:.                  .:.|.::|| .|||
Zfish   248 ASRTSKPS---ATYFPSSTNAPSCNISIHQT------------------PSSGTTSEPQCPSGPP 291

  Fly   907 ---------------RITSLS--KENEGRPPSSRSSTSS-WSEEP----------ALTNMDISTG 943
                           |:..::  :|..|...|.....|| .|.||          ..|...:.:.
Zfish   292 AAELKPSVSCTHSPFRMKPVAGLQERRGSNVSLVLDMSSLGSVEPLNCGVVTPRERATQEYLQSA 356

  Fly   944 HMVLS--YMEDHLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNH 1006
            ..|||  .:.|..:|...|..|:..:.....:   ::....|.....||....||..||||:|..
Zfish   357 SRVLSRKQLRDVTQNTHVLHAEFAEIPMNFVD---QKELDVPNHGSKNRYKTILPNPHSRVILKT 418

  Fly  1007 LANAEGL-DYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVA 1070
            ..:.:.| .|:||:.|..:.....|::|.|||:.:|:..||||:|::...|||.:.:|:|..| .
Zfish   419 KNSNDPLSSYINANYIRGYLGVERAFIATQGPMINTVNDFWQMVWQEDCPVIVMITKLKEKNE-K 482

  Fly  1071 CARYWPEEGAEVYHIYEVHL--VSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPA 1133
            |..||||:.. :|...||.:  |.|   ||.|::|:..|||  ..::|.|..:.:.|||....|.
Zfish   483 CVLYWPEKRG-IYGKVEVSVNNVKE---CDHYIIRTLNLKN--GGQSRKVQHYWYTSWPDHKTPE 541

  Fly  1134 QAKALLDFRRKVNKSYRG-RRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGARE------IDIA 1191
            .|..||.....|.:..:| ..|.|:|||.|||.||||.::...:       |.|:      :|:.
Zfish   542 SAGPLLQLVNDVEEDRKGWTSSGPVVVHCSAGIGRTGCFMATTI-------GCRQLGLEGLVDVL 599

  Fly  1192 ATLEHLRDQRAGVVATRQQFEFVLMAVA 1219
            ..:..||..|.|::.|.:|:|||..|::
Zfish   600 GIVCQLRTDRGGMIQTEEQYEFVHHALS 627

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	21/99 (21%)
		PTP_DSP_cys	942..1225	CDD:475123	92/290 (32%)
ptprr	XP_073804489.1	None