Protein Alignment IA-2 and ptprt

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_004918595.1
• Gene: ptprt / 100496210
• XenbaseID: XB-GENE-5717729
• Length: 1486
• Species: Xenopus tropicalis
• Alignment Length: 956
• Identity: 222/956 - (23%)
• Similarity: 350/956 - (36%)
• Gaps: 280/956 - (29%)

  Fly   487 EEVEDEQPKRSFFRELAG---EQGLVQEPPLRFRHVETEVDATPELVKRRPAS------------ 536
            :|||        :|..:|   |..::..|..:..|::.:|:....::..||..
 Frog   314 KEVE--------YRTTSGSWAETHVMDGPTYKLWHLDPDVEYEIRVLLTRPGEGGTGPPGPPLTT 370

  Fly   537 -FKQLDP---------YDVSLQQQEMAFESGLLRNSLTPLEEEAMLASNSFPRQAKSQRV----- 586
             .|..||         .|:..:|..:.:|.  ...|:|......:....||  |....||
 Frog   371 RTKCADPVHGPQNVELVDIRARQLTLQWEP--FGYSVTRCHSYNLTLHYSF--QLGEDRVEAEEL 431

  Fly   587 ------YTEGGL-----------LLMPQDEQDTDGMQADEPENVKQSL-LANMLGFARHER--LD 631
                  ||..||           |..|:..:::..:.....|:|...: |.::.|....|:  |.
 Frog   432 VLTSSHYTLRGLRPHTAVYLRLALCNPEGRKESGEIVVHTEEDVPGPIPLESIQGGPFEEKIYLQ 496

  Fly   632 VKKPGPLLGPPSL------------GSAELSNQ------LETE------------------KAHK 660
            .|.|....|..|:            .||:||||      |..|                  :|..
 Frog   497 WKAPNETNGVISMYEVTYKAVGSLDPSADLSNQKGRIFKLRNETHHLFVGLYPGSTYSFTIRAST 561

  Fly   661 QKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVK------NPIDSW 719
            .||.|  ..:.|.|         ..|........:|..||.......:.|::|      .|:.::
 Frog   562 SKGFG--PPVTARI---------ATKIAAPSLTDSEAEAPLNETESTITVWLKPAQSRGAPVSAY 615

  Fly   720 NDGQRIMKELE-----------------------QILHMQGYF------SYLTVQQHEVSFRVNS 755
               |.::||..                       ..|....||      |.|.|.|   .|.|..
 Frog   616 ---QLVVKEERAQRSGRAADGSGCFPVPVGYRNASSLESSHYFAAELKPSQLAVTQ---PFTVGD 674

  Fly   756 NNPERKTAGDVARTINENRGVKN-------------------NIQRRVGFYVL--HAGVGDVIKD 799
            |           ||.|   |..|                   |.:.::|...|  .|....::..
 Frog   675 N-----------RTYN---GYWNPPLSPVKSYSIYFQALSTANGETKIGCVRLASKAATAGLLPI 725

  Fly   800 LQDP---------SVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRH------- 848
            .:.|         :::|:.:| .|:..|.|...|.:.||. ...:|::...::.|||.
 Frog   726 TRHPPSQPVTGASTLNSNTVE-PEKPADSTVQTAGVIAGM-LMFIIILLGAMMTIKRRRNVYSYS 788

  Fly   849 -------------------------DRKRDKLGGLQ-----------SGIAGAETC-----SKDY 872
                                     |:...||...:           :|.:.:..|     ||:.
 Frog   789 YYLKLAKKQKETQSGSQREMGLVASDKSSSKLSSTRNEDTFSSCQDVNGFSSSSPCSFSVQSKNI 853

  Fly   873 QELCRARMAGKAGGGGNSTGGAAGGGSNEPAPSGRITSLSKENEGRPPSSRSSTSSWSEEPALTN 937
            |              |.|...:....|::..||..:...|..:..:|..:..:....:.||  ..
 Frog   854 Q--------------GKSLLSSCYSVSSDTVPSLALLDNSHVDMNQPTLTIQTHPYRTCEP--LE 902

  Fly   938 MDISTGHM--------VLSYMEDHLRNKG-RLQREWEALCRYEAEPSAREAASQPQCAGLNRPGA 993
            |....|.:        :|.::....|.:| ..:.|:|||  .|.:.::.:.|.:.:....||.|.
 Frog   903 MAYPRGQLQPAIRVADLLQHITQMKRGQGYGFKEEYEAL--PEGQTASWDTAKEDENRNKNRYGN 965

  Fly   994 PLPYDHSRVVLNHLANAEGLDYVNASTITD-HDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVI 1057
            .:.||||||.|..:......||:||:.:.. |.||  .|:|.|||:..|:..||:|||::.:|.:
 Frog   966 IISYDHSRVRLQQIEGDPHSDYINANYVDGYHRPR--YYIATQGPMQETVKDFWRMIWQENSVSV 1028

  Fly  1058 VALCRLQENGEVACARYWPEEGAEVYHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFH 1122
            |.:..|.|.|.|.|.||||:| .|||...:|.|:...... :|::|:|.::...:.:.|.:.|||
 Frog  1029 VMVTNLVEVGRVKCVRYWPDE-TEVYGDIKVSLIETEPLA-EYVIRTFTVQKKGSHDIREIRQFH 1091

  Fly  1123 FLSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERM-NKGAR 1186
            |.|||..|||..|..||.|.|:| |......:.||.||.||||||||..|.:|::|:.. |:|.
 Frog  1092 FTSWPDHGVPCYATGLLGFIRQV-KFLNPPDAGPITVHCSAGAGRTGCLIAIDIMLDMAENEGV- 1154

  Fly  1187 EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPAN 1232
             :||...:..||.||..:|.|.:|:.||..|:.|.......|:|.:
 Frog  1155 -VDIFNCVRELRAQRVNMVQTEEQYVFVHDAILEACLCGNTAIPVS 1199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	25/145 (17%)
		PTP_DSP_cys	942..1225	CDD:475123	106/293 (36%)
ptprt	XP_004918595.1	MAM	21..180	CDD:214533
		Ig	187..272	CDD:472250
		FN3	280..351	CDD:214495	9/44 (20%)
		FN3	381..471	CDD:238020	16/93 (17%)
		fn3	493..568	CDD:394996	17/76 (22%)
		R-PTPc-T-1	955..1191	CDD:350478	96/242 (40%)
		R-PTPc-T-2	1276..1481	CDD:350482