Protein Alignment IA-2 and ptprn2

DIOPT Version :9

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_002935220.2
• Gene: ptprn2 / 100495746
• XenbaseID: XB-GENE-12565070
• Length: 1049
• Species: Xenopus tropicalis
• Alignment Length: 1188
• Identity: 395/1188 - (33%)
• Similarity: 564/1188 - (47%)
• Gaps: 253/1188 - (21%)

  Fly   155 GVLLLILLLATHGDL---AQAEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDIEKTP 216
            |.|.:..||.:...|   .:||...||.|...|| ...|||.:|.:||:|.....:||...|.:|
 Frog     2 GSLCIAFLLLSASSLRVTVRAEKQFGCLFEEDLC-KSFEVCLNDGVFGRCQRLPVIDVFKYEVSP 65

  Fly   217 LTEDQSRVLATMLEELQGAGLGWDHPYVQCRIQGSLFSLQRQQQLPPNLCANLAPTPPEFGDPAS 281
            ....:   |..:|::|...||.|...:.|..|...|.::::.....|:..::       .|...|
 Frog    66 AVVQR---LQAILQKLSHKGLTWKDDFTQQIIAKELSNIRKIYSRQPDALSS-------DGSSTS 120

  Fly   282 ALAYVRF-TPPEPEAE---------------LDYYEQPAGPAQFYPALR-KKQVRESD--ADDMY 327
            ..:.:.. :..:.|:|               |....|||.|: |||..: :|.:.::|  ..|.:
 Frog   121 RASQINAESDRDHESEKNANFAKSFHRYLQYLGILPQPALPS-FYPRTKTEKPLIKTDNIKSDRF 184

  Fly   328 LNRMLQDRR----RLRHDPSELEHFGKMDGHGQSTQLDAPSIMDAFLDTERQR--IEREQQLA-- 384
            ::|:.|..:    .|.:.|..|.        ..:.....|......||.|::.  |..:..||
 Frog   185 IDRIFQKSKGKLPMLSYPPENLP--------SNTLTQPVPGKFPKKLDQEKKSLLIALKAYLAQK 241

  Fly   385 AAEQDADRRAEQNRLELYQILAASEPD-----PQ--------------------PYQRKPAAQPN 424
            ..|.::|:.....|.:.|    :|.|:     ||                    .:.::|.|...
 Frog   242 TMEHNSDKTNPNGRAKFY----SSTPNRYLSLPQMKLLDGVLPKDDKGDGFKIKSFLQRPKAGVL 302

  Fly   425 AMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEV--NESSEL----YFPDNFAPFKRARGRSRG 483
            :...|.|::.:...|     .|..|.|:....|..  |...||    ...||.:|      :...
 Frog   303 SKPSLGALIYKSSSR-----LEDPKDPLSAVDETFIQNVVKELGKHKLNVDNLSP------KELD 356

  Fly   484 GLAEEVED-------EQPKRSFFRELAGEQG----LVQEPPLRFRHVETEVD--ATPELVKRRPA 535
            .||:.:.|       |||..   :::.||:.    ...||.....:.:.|:|  ...:..|.:.:
 Frog   357 ELADVIADTLQFVDMEQPSS---KKIEGEREEHDINPTEPQGSQENTDGEIDNMFQDQETKEKDS 418

  Fly   536 SFKQLDPYDVSLQQQEMAFESGLLRN-SLTPLEEEAMLASNSFPRQAKSQRV----YTEGGLLLM 595
            .::        ::.:|...:.|.|.. :..|.|:|.|   :..|..::.:|.    |..
 Frog   419 QYE--------MKVKETGSKDGYLPGFTGNPPEKEFM---SEEPISSELRRFGDINYNS------ 466

  Fly   596 PQDEQDTDGMQADEPENVKQSLLANMLGFARHERLDVKKPGPLLG----PPSLGSAELSNQLETE 656
            .:||::..|:     ||||.......|...:....|:.....:.|    ..||...|.|...|.:
 Frog   467 DEDEEEKYGI-----ENVKSETYTRELNAQKKSAEDIDSREFIEGQHWVEESLAQEEKSYFEEPK 526

  Fly   657 KAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHSAEDHAPHTVDTEYVHVFVKNPIDSWND 721
            |.:       .|.|...:|.:..|         :..:.....:|.||:                .
 Frog   527 KVY-------VEGLQLQVKSSSSD---------RYGYIVTQKSPLTVE----------------K 559

  Fly   722 GQRIMKELEQIL-HMQGYFSYLTVQQHEVSFRVNSNNPERKTAGDVARTINENRGVKNNIQRRVG 785
            |..::.|:..|| |....||.::|....|.|:| |::....||.|||.....|   |:.:::..|
 Frog   560 GLELLNEVALILKHQMNVFSDVSVSGSAVMFQV-SSHVRNLTAEDVAHAAAAN---KDALEKSTG 620

  Fly   786 FYVLHAGVGDVIKDLQDPSVSSSRIE-----LAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILI 845
            ..:|..|||:           .|:::     |.|:  |.|..               |.:|||.|
 Frog   621 LKILQTGVGE-----------KSKLKFLPHHLEEE--DTTKF---------------IILTLISI 657

  Fly   846 ------------------KRHDRKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKAGGGGNSTG 892
                              :.|.:.::||..|  |.......:..||||||.|||.|:
 Frog   658 ACIIGVLTGSGVIYCLRHQSHHKLKEKLSSL--GTDANTDATHTYQELCRQRMAVKS-------- 712

  Fly   893 GAAGGGSNEPAP--SGRITSLSKENEGRP---PSSRSSTSSWSEEPALTNMDISTGHMVLSYMED 952
                  |:.|..  |.||.|:|.:....|   |::|||||||.|||..:|||||||||:||||||
 Frog   713 ------SDRPEAQHSSRINSISSQFSDGPMPSPTARSSTSSWCEEPVQSNMDISTGHMILSYMED 771

  Fly   953 HLRNKGRLQREWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVN 1017
            ||:||.||::||||||.|:|||:|...|.:.:....||..|.:||||||::|....:.:..||:|
 Frog   772 HLKNKNRLEKEWEALCAYQAEPNATNIAHKEESMSKNRSLAIVPYDHSRIILKTENSHDNSDYIN 836

  Fly  1018 ASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEV 1082
            ||.|.|||||.|||:|.|||||:|:|.||||:||.|.||||.|..|.|||...|..|||:||:.:
 Frog   837 ASPIMDHDPRNPAYIATQGPLPATVADFWQMVWENGCVVIVMLTSLTENGVKQCYHYWPDEGSNL 901

  Fly  1083 YHIYEVHLVSEHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNK 1147
            ||||||:||||||||:|:||||||||||:|:||||||||:||:|...||||..::||||||||||
 Frog   902 YHIYEVNLVSEHIWCEDFLVRSFYLKNLQTNETRTVTQFNFLNWNDQGVPASTRSLLDFRRKVNK 966

  Fly  1148 SYRGRRSCPIVVHGSAGAGRTGVYILLDLVLERMNKGAREIDIAATLEHLRDQRAGVVATRQQFE 1212
            .|:| ||||::||.|.||||:|.|||:|:||.:|.|||:|||||||||||||||.|:|.|::|||
 Frog   967 CYKG-RSCPVIVHCSDGAGRSGTYILIDMVLNKMAKGAKEIDIAATLEHLRDQRPGMVQTKEQFE 1030

  Fly  1213 FVLMAVAEEVHAILKALP 1230
            |.|.||||||:|||||||
 Frog  1031 FALTAVAEEVNAILKALP 1048

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410	23/87 (26%)
		PTPc	960..1220	CDD:214550	167/259 (64%)
		PTPc	995..1220	CDD:238006	151/224 (67%)
ptprn2	XP_002935220.2	RESP18	62..>120	CDD:291609	13/67 (19%)
		Receptor_IA-2	546..631	CDD:288410	27/115 (23%)
		PTPc	779..1038	CDD:214550	167/259 (64%)
		PTPc	807..1038	CDD:238006	154/231 (67%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	331	1.000	Domainoid score	I1163
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	522	1.000	Inparanoid score	I1233
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D281324at33208
OrthoFinder	1	1.000	-	-		FOG0002390
OrthoInspector	1	1.000	-	-		otm49483
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1583
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.060