Protein Alignment IA-2 and ptprb

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: NP_001303656.2
• Gene: ptprb / 100149130
• ZFINID: ZDB-GENE-101108-3
• Length: 1892
• Species: Danio rerio
• Alignment Length: 688
• Identity: 161/688 - (23%)
• Similarity: 248/688 - (36%)
• Gaps: 211/688 - (30%)

  Fly   694 SAEDHAP--------HTVDT-----EYVHVFVKNPID------SWN------DGQRIMKELEQIL 733
            |.:.|:|        ||:.|     ..:|.|   |:.      ||.      ||..:.      .
Zfish  1240 SGKRHSPVTYSCPVYHTIRTPPLPAPSIHCF---PLSSTSVSCSWTPPHSDFDGFVVQ------C 1295

  Fly   734 HMQGYFSYLTVQQHEVSFRVNSNNPER------------KTAGDVARTINENRGVKNNIQRRVGF 786
            |.||  |...|..|.:..|..|...:|            ..:||     .::..|||:
Zfish  1296 HRQG--SGKAVYTHTLGNRTLSQRFDRLEPFKNYTIYVAVMSGD-----KQSSTVKNS------- 1346

  Fly   787 YVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIM------AYMFAGAGAAAVIVIFVTLILI 845
                     ||..:..|.|....:.:.|....:||..      ...|:.|..|   :.:.|:|..
Zfish  1347 ---------VITMIDRPPVPPVTVRVNEHSAVITHFTIRFKFNCSWFSDANGA---IRYFTIIAT 1399

  Fly   846 KRHD------------------RKRDKLGGLQSGIAGAETCSKDYQELCRARMAGKA-------G 885
            :.:|                  |:...:...|:|.         :...|.....||.       |
Zfish  1400 ESNDVDNGLPEQRHPLPSYLDYRQNHSIKAYQTGY---------FHSTCAEGSDGKVQVFEINLG 1455

  Fly   886 GGGNSTGGAA-------GGGSN-------------------------------EPAPSGRITSLS 912
            .|....|||.       ..||:                               .|..:....||.
Zfish  1456 AGMKHLGGACKLDPESIQHGSHLCDGPLRSRTSYRLSVRAFTQLFDEENREFPHPLYTDTYLSLP 1520

  Fly   913 KENEGRPPS--------------------------SRSSTSSWSEEPALTNMD---ISTGHMVL- 947
            ...:..|.|                          .|:...:..|.|.:....   :.|..|.|
Zfish  1521 LLTQSAPRSGLTGGITAALFLITMVLALTALLIYRKRAHKIAVQESPVMKMCKWKALPTSQMCLR 1585

  Fly   948 -------SYMEDHLR-----NKGRLQREWEAL---CRYEAEPSAREAASQPQCAGLNRPGAPLPY 997
                   :..|.||.     :...|..|:|.|   .|.:.:.:||...::.:    ||....|||
Zfish  1586 IRSPVQAANFESHLAKLQSDSSYLLSEEFEGLKDVGRIQTQNAARLLGNRNK----NRYNNILPY 1646

  Fly   998 DHSRVVLNHLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCR 1062
            |.:||.|:.|.:....||:||:.|..::.|. .|:|.|||||.|...||:|:|||....:|.:.:
Zfish  1647 DSTRVRLSCLEDDPCSDYINANYIPGNNFRW-EYIATQGPLPGTKDDFWRMVWEQNVHSLVMVTQ 1710

  Fly  1063 LQENGEVACARYWPEEGAEV-YHIYEVHLVSEHIWCDDYLVRSFYL---KNLRTSETRTVTQFHF 1123
            ..|.|.|.|..|||.:...: |....|.|:||.:: .::.:|.|.:   ..||  ..|.|.|||:
Zfish  1711 CVERGMVKCDHYWPTDSEPLCYGDIVVQLLSEKVF-PEWTIRDFKISCESQLR--YPRMVRQFHY 1772

  Fly  1124 LSWPHMGVPAQAKALLDFRRKVNKSYRGRRSCP--IVVHGSAGAGRTGVYILLDLVLERMNKGAR 1186
            ..||..|||...::|:.|.|.| :.:..|.:.|  .|||.|||.||||.:|:||..|:::::..
Zfish  1773 TIWPDHGVPDTTQSLIQFVRTV-RDFINRTNSPGISVVHCSAGVGRTGTFIVLDRALQQLDRNC- 1835

  Fly  1187 EIDIAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHA 1224
            .:||...:..||..|:.:|.|..|:.::...|.:.:.|
Zfish  1836 TVDIYGCVFDLRLHRSYMVQTECQYAYIHQCVRDVLRA 1873

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	22/118 (19%)
		PTP_DSP_cys	942..1225	CDD:475123	100/305 (33%)
ptprb	NP_001303656.2	None