Protein Alignment IA-2 and ptprdb

DIOPT Version :10

• Sequence 1: NP_608562.4
• Gene: IA-2 / 33277
• FlyBaseID: FBgn0031294
• Length: 1319
• Species: Drosophila melanogaster
• Sequence 2: XP_021330819.2
• Gene: ptprdb / 100073332
• ZFINID: ZDB-GENE-070615-38
• Length: 1952
• Species: Danio rerio
• Alignment Length: 1236
• Identity: 262/1236 - (21%)
• Similarity: 432/1236 - (34%)
• Gaps: 352/1236 - (28%)

  Fly   152 LQFGVLLLILLLAT----HGDLAQAEGNVGCQFVRTLCIPHSEVCYDDNIFGKCIPTTGVDVEDI 212
            |..|||.:..|.|.    :|..||.          ||.||:......|.:....:.|.|..:...
Zfish   892 LSAGVLYVFRLAARTVWGYGSSAQV----------TLLIPNVVQTTTDGMITDLMTTEGQTMSVQ 946

  Fly   213 EKTPLTEDQSRVLATMLEE---LQGAGLGWDHPYVQCRIQG------------------------ 250
            |..|       :||.:..|   ...|.|.|:.|.....|||
Zfish   947 ENVP-------ILANLTAESINSSSAILRWERPKNYDGIQGYRVWFAVTYSNGTDIAMESDVSET 1004

  Fly   251 --SLFSLQRQQQLPPNLCANLAPTPPEFGDPASALAYVRFTPPEPEAELDYYEQPAGPA------ 307
              .|..|:...:....:|......|..:..|.|    ::..|.|....:::..:.|..:
Zfish  1005 TVVLHGLRANTEYVARVCMLSKQGPGPYSLPIS----IKTQPAEEVFAVNFKVKAAMKSSVLLTW 1065

  Fly   308 QFYPALRKKQ---VRESDADDMYLNRMLQDRRRLRHDPSELEHF---GKMDGHG----QSTQLDA 362
            :......|.|   :...|.:.:.::..|..:...:..|..|.:|   .|.|..|    ::..:.|
Zfish  1066 ESRTTSNKAQSLIISYGDGESVEVDGRLGQKLVTKLKPQSLYNFLLTSKSDSTGGLQHRTDAMTA 1130

  Fly   363 PSIM---DAFLDTERQRIEREQQLAAAEQDADRRAEQNRLELYQILAASEPDPQPYQRKPA---- 420
            |::|   ...||....:.....||...:..|:.|.       :.||..      |.:|:.|
Zfish  1131 PNLMTRKPQLLDKTSSQSIAILQLPTVQGQANVRG-------FYILVV------PLKRQRAGNFQ 1182

  Fly   421 ---AQPNAMDQLEAIVEQQQQRELKEQQEQAKAPVYVPPEEVNESSELYFPDNFAPFKRARGRSR 482
               :.|:.|:..|.:.|..........:.||:|..|:         ..:|.:..|.||...|...
Zfish  1183 NMWSDPDEMNLDELLREINGTGRSVRLRRQAEAKPYI---------TAHFQNLPAEFKLGDGHVY 1238

  Fly   483 GG-LAEEVEDEQPKRSFFREL--AGEQGLVQEPP----LRFRHVETEVDATPE------------ 528
            |. :...:.:.|....|...:  .|:..:....|    :.|..||.:.....|
Zfish  1239 GAFMNRPLVNGQEYVCFVLAILELGQNTVYSTSPFSDAVLFSDVEPQPIVDEEEGLLWVVGPVLA 1303

  Fly   529 ------------LVKRRPASFKQLDPYDVSLQQQEMAF-ESGLLRNSLTPLEEEAMLASNSFPRQ 580
                        |.|.:|      |.....|:.::.:| .||...:|..| .:...|...:||
Zfish  1304 VIFIISIVILILLFKSKP------DRKRAELEGRKCSFLSSGKAMSSQHP-SDPVELRRINFP-- 1359

  Fly   581 AKSQRVYTEGGLLLMPQDEQDTDGMQADEPENVK------QSLLAN-MLGFAR-HERLDVKKPGP 637
                                 |.||.:..|.:|.      :.:.|| .|.|:: :|.:|   ||
Zfish  1360 ---------------------TAGMTSHPPVSVSELPAHIERMKANDSLRFSQEYESID---PG- 1399

  Fly   638 LLGPPSLGSAELSNQLETEKAHKQKGHGNKEVLPAHIKGNDEDDAHKKKKVMKQQHS--AEDHAP 700
                         .|...|       |.|.|:         ....::...|:...|:  |..:..
Zfish  1400 -------------QQFSWE-------HSNLEI---------NKPKNRYANVIAYDHTRVALTNTD 1435

  Fly   701 HTVDTEYV-------------HVFVKNPI-DSWNDGQRIMKE-----------LEQILHMQGYFS 740
            .....:|:             ::..:.|: |:::|..|::.|           ||:...|..||
Zfish  1436 GVAGGDYINANFIDGYRRQGAYIATQGPMPDTFSDFWRMVWEQHTANVIMITKLEEKSRMPSYF- 1499

  Fly   741 YLTVQQHEVSFRVNSNN---PERKT----------------AGDVART---INENRGVKNNIQRR 783
                      |..|..:   |.|.|                |....||   .....|.|..:::
Zfish  1500 ----------FSKNKCDQYWPSRGTETYGLMQVSLLDTVELATYCVRTFALFKSGSGEKREVRQ- 1553

  Fly   784 VGFYVLHAGVGDVIKDLQDPSVSSSRIELAEQGPDVTHIMAYMFAGAGAAAVIVIFVTLILIKRH 848
               :...|.....:.:...|.::..|...|...||...|:.:..||.|.....::...::...:.
Zfish  1554 ---FQFTAWPDQGVPEHPTPFLAFLRRVKACNPPDAGPIVVHCSAGVGRTGCFIVIDAMLERVKQ 1615

  Fly   849 DRKRDKLGGLQSGIAGAETCSKD---------------YQELCRARMAGKAGGGGNSTGGAAGGG 898
            ::..|        |.|..|..:.               |:.|..|...|
Zfish  1616 EKTLD--------IYGHVTLMRSQRNYMVQTEEQYVFIYEALLEAVSCG---------------- 1656

  Fly   899 SNEPAPSGRITS-LSKENEGRPPSSRSSTSSWSEEPALTNMDISTGHMVLSYMEDHLRNKGRLQR 962
             |...|:..:.: :.:.::..||                               :|:..   :::
Zfish  1657 -NTEVPARNLYAYIQRLSQTEPP-------------------------------EHISG---MEQ 1686

  Fly   963 EWEALCRYEAEPSAREAASQPQCAGLNRPGAPLPYDHSRVVLNHLANAEGLDYVNASTITDHDPR 1027
            |::.|...:|..|...:||.|.....||....:||:.:||.|..:...||.||||.|.| |...:
Zfish  1687 EFKRLANAKAHNSRFVSASLPCNKFKNRLVNIMPYESTRVCLQPIRGVEGSDYVNGSFI-DGYRQ 1750

  Fly  1028 APAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVACARYWPEEGAEVYHIYEVHLVS 1092
            ..||:|.||||..|:..||:|:||..:.::|.|.:|:|.|...|.:|||.:.:..|..:.|..::
Zfish  1751 QRAYIATQGPLAETVEDFWRMLWEHNSTIVVMLTKLREMGREKCHQYWPSDRSARYQYFVVDPMA 1815

  Fly  1093 EHIWCDDYLVRSFYLKNLRTSETRTVTQFHFLSWPHMGVPAQAKALLDFRRKVNKSYR--GRRSC 1155
            |:. ...|::|.|.:.:.|..::|||.||.|..||..|||...:..:||..:|:|:..  |:..
Zfish  1816 EYN-MPQYILREFKVTDARDGQSRTVRQFQFTDWPEQGVPKSGEGFIDFIGQVHKTKEQFGQDG- 1878

  Fly  1156 PIVVHGSAGAGRTGVYILLDLVLERMN-KGAREIDIAATLEHLRDQRAGVVATRQQFEFVLMAVA 1219
            ||.||.|||.|||||:|.|.:|||||. :|.  :||..|::.||.||..:|.|.:|::|...|..
Zfish  1879 PITVHCSAGVGRTGVFITLSIVLERMRYEGV--VDIFQTVKMLRTQRPAMVQTEEQYQFCYRAGL 1941

  Fly  1220 E 1220
            |
Zfish  1942 E 1942

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
IA-2	NP_608562.4	Receptor_IA-2	705..795	CDD:463293	22/136 (16%)
		PTP_DSP_cys	942..1225	CDD:475123	102/282 (36%)
ptprdb	XP_021330819.2	None