DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and TMTC4

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001337500.1	Gene:	TMTC4 / 84899	HGNCID:	25904	Length:	818	Species:	Homo sapiens

Alignment Length:	954	Identity:	260/954 - (27%)
Similarity:	376/954 - (39%)	Gaps:	292/954 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    40 SLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLCVLSF 104
            |:|.|.:..:....||:||..||:.|.|:...||....:.:||||:.|:.:.||.|:|||.||:|
Human    47 SVAIVCFARSYDGDFVFDDSEAIVNNKDLQAETPLGDLWHHDFWGSRLSSNTSHKSYRPLTVLTF 111

  Fly   105 RLNYLIGGGFAPWGFHLVNNLLHCVATALVVRV-------------ARTLLASVWAVLAAGALFA 156
            |:||.:.|||.|.|||:||.|||...:.|:|.|             .|.|..:..|.|.|..|||
Human   112 RINYYLSGGFHPVGFHVVNILLHSGISVLMVDVFSVLFGGLQYTSKGRRLHLAPRASLLAALLFA 176

  Fly   157 AHPIHTEAVAGVVGRADLAACVCYLLTYLSYLRHMRWRESG-----DPRQWLALGATLILAAAGL 216
            .||:|||.||||||||||...:.:||::|.|.:  .:|||.     ....|:.|  ::.|.|..:
Human   177 VHPVHTECVAGVVGRADLLCALFFLLSFLGYCK--AFRESNKEGAHSSTFWVLL--SIFLGAVAM 237

  Fly   217 LCKETAITALLVCALFDVM---------RGL-------------------------------SGQ 241
            ||||..|| :|.|.|.:|.         :||                               ..|
Human   238 LCKEQGIT-VLSCKLIEVAVLHTTALPGKGLLSSMCGFQSHPVHLHSSQLEGETKWECVPKFYNQ 301

  Fly   242 VDKQRLRSVCIVL------------------------------GALFCMA----------YCRLV 266
            ..|..|.:|..:|                              |.||.|.          |.|..
Human   302 TSKMGLNAVFDILVIGKFNVLEIVQKVLHKDKSLENLGMLRNGGLLFRMTLLTSGGAGMLYVRWR 366

  Fly   267 IVPGPQTAFSSADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRR 331
            |:.....||:..|||.:...|...|.:.:.|....|..|||.|..|.|||.|..:|.:.|:.|.|
Human   367 IMGTGPPAFTEVDNPASFADSMLVRAVNYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSISDWR 431

  Fly   332 NAQSACFYSVLVGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQ 396
            ....|..:..|:|:.   |:.|.|   |..|                      ||:
Human   432 VIALAALWFCLIGLI---CQALCS---EDGH----------------------KRR--------- 459

  Fly   397 AFEAAYHQQQQEALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNS 461

Human   460 ----------------------------------------------------------------- 459

  Fly   462 SSSSSSSSSSSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYV 526
                                                      :|.:.|.||.:||||||||.|.|
Human   460 ------------------------------------------ILTLGLGFLVIPFLPASNLFFRV 482

  Fly   527 GFVVAERLLYLPSVGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLR---RNADWRD 588
            |||||||:|||||||:|:|:.:|...|   ::.|:...|:: :::|..:.:.|||   |:.:||.
Human   483 GFVVAERVLYLPSVGYCVLLTFGFGAL---SKHTKKKKLIA-AVVLGILFINTLRCVLRSGEWRS 543

  Fly   589 EESLYRSAIAINP--PKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQV 651
            ||.|:|||:::.|  .|...|:|..|:.:|....|.:..:||:|..|.......|||.:.:.:..
Human   544 EEQLFRSALSVCPLNAKVHYNIGKNLADKGNQTAAIRYYREAVRLNPKYVHAMNNLGNILKERNE 608

  Fly   652 YPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSS 716
            ...|.|....|::.:|:.|.|::||||...:| ||.:|.|          .:.|....|.:....
Human   609 LQEAEELLSLAVQIQPDFAAAWMNLGIVQNSL-KRFEAAE----------QSYRTAIKHRRKYPD 662

  Fly   717 AYLQLGALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALE 781
            .|..||.||.:..:...||..:|.|....|    :..:.:..:..:|.......:||...|.|||
Human   663 CYYNLGRLYADLNRHVDALNAWRNATVLKP----EHSLAWNNMIILLDNTGNLAQAEAVGREALE 723

  Fly   782 LQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLAPEQAS-------VYHHYAEFLSLQSRHH 839
            |.||..:...|....|.: |.:..|:|..|.:|:|..|..||       :||.:.. |.|..:|:
Human   724 LIPNDHSLMFSLANVLGK-SQKYKESEALFLKAIKANPNAASYHGNLAVLYHRWGH-LDLAKKHY 786

  Fly   840 ESAIYHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAV 883
            |.::.....|.....:|          .||.||:  |:..:|||
Human   787 EISLQLDPTASGTKENY----------GLLRRKL--ELMQKKAV 818

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	57/137 (42%)
		DUF1736	275..343	CDD:285594	22/67 (33%)
		TPR_11	602..667	CDD:290150	16/64 (25%)
		TPR_1	602..634	CDD:278916	9/31 (29%)
		TPR repeat	602..630	CDD:276809	8/27 (30%)
		TPR repeat	635..665	CDD:276809	6/29 (21%)
		TPR_11	636..700	CDD:290150	18/63 (29%)
		TPR_1	636..668	CDD:278916	6/31 (19%)
		TPR repeat	670..694	CDD:276809	11/23 (48%)
		TPR_11	714..784	CDD:290150	18/69 (26%)
		TPR repeat	715..743	CDD:276809	9/27 (33%)
		TPR repeat	748..782	CDD:276809	6/33 (18%)
		TPR_11	755..819	CDD:290150	18/63 (29%)
		TPR repeat	787..816	CDD:276809	7/28 (25%)
		TPR_11	821..887	CDD:290150	18/70 (26%)
		TPR repeat	822..850	CDD:276809	8/34 (24%)
		TPR repeat	855..885	CDD:276809	9/29 (31%)
		TPR_11	<874..921	CDD:290150	4/10 (40%)
		TPR repeat	890..918	CDD:276809
TMTC4	NP_001337500.1	DUF1736	369..443	CDD:369859	23/73 (32%)
		TPR	558..794	CDD:223533	67/252 (27%)
		TPR repeat	559..587	CDD:276809	8/27 (30%)
		TPR repeat	592..622	CDD:276809	6/29 (21%)
		TPR repeat	627..655	CDD:276809	12/38 (32%)
		TPR repeat	661..687	CDD:276809	8/25 (32%)
		TPR repeat	695..723	CDD:276809	5/27 (19%)
		TPR repeat	728..758	CDD:276809	7/30 (23%)
		TPR repeat	763..791	CDD:276809	8/28 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.820