Protein Alignment Tmtc2 and TMTC1

DIOPT Version :10

• Sequence 1: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_001354804.1
• Gene: TMTC1 / 83857
• HGNCID: 24099
• Length: 944
• Species: Homo sapiens
• Alignment Length: 1071
• Identity: 287/1071 - (26%)
• Similarity: 418/1071 - (39%)
• Gaps: 366/1071 - (34%)

  Fly    46 YLNTLGAGFVYDDRRAILANADVSGGTP--WQRSFSNDFWGTPLTDSGSHGSWRPLCVLSFRLNY 108
            |..:|...||:||..||:.|.||..|.|  | ..|:|||||..:.::.||.|:||||||:|:||.
Human    41 YGRSLQGEFVHDDVWAIVNNPDVRPGAPLRW-GIFTNDFWGKGMAENTSHKSYRPLCVLTFKLNI 104

  Fly   109 LIGGGFAPWGFHLVNNLLHCVAT-ALVVRVARTLLASVWAVLAAGALFAAHPIHTEAVAGVVGRA 172
            .: .|..|:.||.||.:|||:.| .|:....:|:..:.........|||.||||||||||:||||
Human   105 FL-TGMNPFYFHAVNIILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPIHTEAVAGIVGRA 168

  Fly   173 DLAACVCYLLTYLSYLRHM-------RWRESGDPRQWLALGATLILAAAGLLCKETAITALLVCA 230
            |:.||:.:||.:|||.|.:       .:..:..|   ..|..:|.|....:|.|||.||...||.
Human   169 DVLACLLFLLAFLSYNRSLDQGCVGGSFPSTVSP---FFLLLSLFLGTCAMLVKETGITVFGVCL 230

  Fly   231 LFDVMRGLSGQVDKQRLRSVC-------------------------------------------- 251
            ::|:. .||.:.||....::|
Human   231 VYDLF-SLSNKQDKSSNGALCPRSPQQPGSPQPSSLPGHPHRENGKQQRFPHKGAWGGCHSPLPP 294

  Fly   252 -----------------------------------------IVLGALFCMAYCRLVIVPGPQTAF 275
                                                     :||..:..:.|.||.|:.|....|
Human   295 EPKSSGFPVSPRAVWSMMRYLRASSNRNFLLTMRPFLKRAILVLSYVLVILYFRLWIMGGSMPLF 359

  Fly   276 SSADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYS 340
            |..|||.:.:|...||.||:.||..||:.|||.|..|.:||.:.::|.|.::||.||. :..|.:
Human   360 SEQDNPASFSPYILTRFLTYSYLLAFNVWLLLAPVTLCYDWQVGSIPLVETIWDMRNL-ATIFLA 423

  Fly   341 VLVGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQ 405
            |::.        |||     .||                         ||      ||:...|::
Human   424 VVMA--------LLS-----LHC-------------------------LA------AFKRLEHKE 444

  Fly   406 QQEALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSS 470
                                                                             
Human   445 ----------------------------------------------------------------- 444

  Fly   471 SSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLL 535
                                              :::.|.||..||:|||||.|.||||||||:|
Human   445 ----------------------------------VLVGLLFLVFPFIPASNLFFRVGFVVAERVL 475

  Fly   536 YLPSVGFCLLVGYGVSKLMS----CNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSA 596
            |:||:|:|:|..:|:|||.:    |...|   |::|..|||...|.:|:::|..|...|||:||.
Human   476 YMPSMGYCILFVHGLSKLCTWLNRCGATT---LIVSTVLLLLLFSWKTVKQNEIWLSRESLFRSG 537

  Fly   597 IAINP--PKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQN---QQVYPAAV 656
            :...|  .|...|..:.|..|||.:||....:.|::..|..|....|||.|.::   .::|
Human   538 VQTLPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTRDTAEAKMY---- 598

  Fly   657 ECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQL 721
              :|||::..|....|..|||....:..|:::||.:|           :|...:....:.||..|
Human   599 --YQRALQLHPQHNRALFNLGNLLKSQEKKEEAITLL-----------KDSIKYGPEFADAYSSL 650

  Fly   722 GALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQ 786
            .:|..||.:.:.|..||:..:.:.|    ....|:...|..|......::|..|::.|::|.|:.
Human   651 ASLLAEQERFKEAEEIYQTGIKNCP----DSSDLHNNYGVFLVDTGLPEKAVAHYQQAIKLSPSH 711

  Fly   787 VAAHLSYGITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLS-------LQSRHHESAIY 844
            ..|.::.| .|.|:....|.||.|:||||::|        |.||.||       ...|:.|:...
Human   712 HVAMVNLG-RLYRSLGENSMAEEWYKRALQVA--------HKAEILSPLGALYYNTGRYEEALQI 767

  Fly   845 HRRAAELAPNDYTLVVAAATAM---------------------------RLL------------- 869
            ::.||.|.|:...|.:|.|..:                           |||
Human   768 YQEAAALQPSQRELRLALAQVLAVMGQTKEAEKMTNHIVSEETGCLECYRLLSAIYSKQENHDKA 832

  Fly   870 -------------DRKVDAEMW-------------------YRKAVALRPGDAHAHTNLGAILHL 902
                         |.||.:|::                   ||.||.|.|..|.|..|:|.|.|:
Human   833 LDAIDKALQLKPKDPKVISELFFTKGNQLREQNLLDKAFESYRVAVQLNPDQAQAWMNMGGIQHI 897

  Fly   903 LGRTNHAAASYKAALRLQPGDAITLGNLAKL 933
            .|:...|.|.|:.||:|.|...:...|||||
Human   898 KGKYVSARAYYERALQLVPDSKLLKENLAKL 928

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468	30/72 (42%)
		TPR	597..852	CDD:440225	70/266 (26%)
		TPR repeat	602..630	CDD:276809	9/27 (33%)
		TPR repeat	635..665	CDD:276809	9/32 (28%)
		TPR repeat	670..694	CDD:276809	7/23 (30%)
		TPR repeat	715..743	CDD:276809	9/27 (33%)
		TPR repeat	748..782	CDD:276809	6/33 (18%)
		TPR	780..>933	CDD:440225	59/231 (26%)
		TPR repeat	787..816	CDD:276809	11/28 (39%)
		TPR repeat	822..850	CDD:276809	8/34 (24%)
		TPR repeat	855..885	CDD:276809	14/101 (14%)
		TPR repeat	890..918	CDD:276809	11/27 (41%)
TMTC1	NP_001354804.1	TMTC_DUF1736	353..427	CDD:462468	30/74 (41%)
		TPR repeat	545..573	CDD:276809	9/27 (33%)
		LapB	549..801	CDD:442196	73/281 (26%)
		TPR repeat	578..605	CDD:276809	9/32 (28%)
		TPR repeat	610..638	CDD:276809	9/38 (24%)
		TPR repeat	644..672	CDD:276809	9/27 (33%)
		TPR repeat	677..707	CDD:276809	6/29 (21%)
		LapB	685..940	CDD:442196	66/253 (26%)
		TPR repeat	712..740	CDD:276809	11/28 (39%)
		TPR repeat	745..771	CDD:276809	6/25 (24%)
		TPR repeat	778..808	CDD:276809	3/29 (10%)
		TPR repeat	814..841	CDD:276809	3/26 (12%)
		TPR repeat	846..880	CDD:276809	8/33 (24%)
		TPR repeat	885..913	CDD:276809	11/27 (41%)