DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and Odad4

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_083194.2	Gene:	Odad4 / 74407	MGIID:	1921657	Length:	624	Species:	Mus musculus

Alignment Length:	553	Identity:	104/553 - (18%)
Similarity:	178/553 - (32%)	Gaps:	152/553 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly   367 STFPQYHIQKVASRKSRSKRKRLANN-TK-YQAFEAAYHQQQQEALPCRDCNNNNSSGYVYEGSS 429
            ||||.|        .:..:|..|... || .|:|..|.|.|..:    ::|....|..|:..|..
Mouse     9 STFPSY--------MAEGERLYLCGEFTKAIQSFTNALHLQSGD----KNCLVARSKCYLKMGDL 61

  Fly   430 PVAQAPAQAPHLVSSAF-------------------------RG-------------SRSSSSCS 456
            ..:...|:|.......|                         ||             .::..:.:
Mouse    62 EKSLNDAEASLRNDPTFCKGILQKAETLYTMGDFEFALVFYHRGYKLRPDREFKVGIQKAQEAIN 126

  Fly   457 NSTNSSSSSSSSSSSSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASN 521
            ||..|.||....:....|..|..:...:...|...::.:|.:.:|......||.    .......
Mouse   127 NSVGSPSSIKLENKGDLSFLSKQAESKKAQQKHLPIKQLSYSTKHEIKRKGSLK----SEKTVRQ 187

  Fly   522 LL--FYVGFVVAERLLYLPSVGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNA 584
            ||  .||.....|:||    :...|:.|            |....|....|::..::....|.|.
Mouse   188 LLGELYVDKEYLEKLL----LDEDLIKG------------TIKSGLTVEDLIMTGINYLDTRSNF 236

  Fly   585 DWRDEESLYR--------------------SAIAINPPKALGNLGSVL---SSQGRYEEAKQVLQ 626
             ||.::.:|.                    |..|....|:|.::..:|   |:.|..::|::||:
Mouse   237 -WRQQKPIYARERDRKLMQEKWLRDRKRSPSQTAHYILKSLEDIDMLLTSGSADGSLQKAEKVLK 300

  Fly   627 EAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIE 691
            :                :|..||:..|...|..........|   |.:.||....||...::.:|
Mouse   301 K----------------VLEWNQEEVPNKDELVGNLYSCIGN---AQIELGQMVAALQSHRKDLE 346

  Fly   692 ILQAGSNLDGAAVRDRTAHD--QARSSAYLQLGALYVEQGKLQRALAIYREALSSLPGLPQQREI 754
            |.:              .||  .|:|.|...:|.::...||.|:|:..:.|.: .|.....::..
Mouse   347 IAK--------------EHDLPDAKSRALDNIGRVFARVGKFQQAIDTWEEKI-PLAKTTLEKTW 396

  Fly   755 LYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLAP 819
            |:..||                |..|||  :|.....|||....:.:....:.|.....::.:|.
Mouse   397 LFHEIG----------------RCYLEL--DQAWQAQSYGEKSQQYAEEEGDLEWQLNASVLVAQ 443

  Fly   820 EQASVYHHYAEFLSLQSRHHESAIYHRRAAELA 852
            .|..:....:...:.:.....:.:.|...|:.|
Mouse   444 AQVKLRDFESAVNNFEKALERAKLVHNNEAQQA 476

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453
		DUF1736	275..343	CDD:285594
		TPR_11	602..667	CDD:290150	13/67 (19%)
		TPR_1	602..634	CDD:278916	8/34 (24%)
		TPR repeat	602..630	CDD:276809	8/30 (27%)
		TPR repeat	635..665	CDD:276809	5/29 (17%)
		TPR_11	636..700	CDD:290150	13/63 (21%)
		TPR_1	636..668	CDD:278916	5/31 (16%)
		TPR repeat	670..694	CDD:276809	7/23 (30%)
		TPR_11	714..784	CDD:290150	16/69 (23%)
		TPR repeat	715..743	CDD:276809	8/27 (30%)
		TPR repeat	748..782	CDD:276809	5/33 (15%)
		TPR_11	755..819	CDD:290150	12/63 (19%)
		TPR repeat	787..816	CDD:276809	4/28 (14%)
		TPR_11	821..887	CDD:290150	4/32 (13%)
		TPR repeat	822..850	CDD:276809	1/27 (4%)
		TPR repeat	855..885	CDD:276809
		TPR_11	<874..921	CDD:290150
		TPR repeat	890..918	CDD:276809
Odad4	NP_083194.2	TPR 1. /evidence=ECO:0000255	11..44		12/40 (30%)
		TPR_11	14..76	CDD:290150	16/73 (22%)
		TPR repeat	14..39	CDD:276809	8/32 (25%)
		TPR repeat	44..74	CDD:276809	6/33 (18%)
		TPR 2. /evidence=ECO:0000255	46..78		6/31 (19%)
		TPR_11	47..110	CDD:290150	9/62 (15%)
		TPR 3. /evidence=ECO:0000255	79..112		2/32 (6%)
		TPR repeat	79..107	CDD:276809	2/27 (7%)
		TPR 4. /evidence=ECO:0000255	273..309		11/51 (22%)
		TPR repeat	309..347	CDD:276809	8/40 (20%)
		TPR_12	314..383	CDD:290160	19/85 (22%)
		TPR 5. /evidence=ECO:0000255	318..351		8/49 (16%)
		TPR 6. /evidence=ECO:0000255	358..391		9/33 (27%)
		TPR repeat	358..383	CDD:276809	7/24 (29%)
		TPR_12	359..427	CDD:290160	19/86 (22%)
		TPR 7. /evidence=ECO:0000255	395..428		11/50 (22%)
		TPR_12	396..466	CDD:290160	14/87 (16%)
		TPR repeat	429..463	CDD:276809	3/33 (9%)
		TPR 8. /evidence=ECO:0000255	435..468		2/32 (6%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	511..624
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900