Protein Alignment Tmtc2 and Ttc6

DIOPT Version :10

• Sequence 1: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_001299573.1
• Gene: Ttc6 / 70846
• MGIID: 2684915
• Length: 1857
• Species: Mus musculus
• Alignment Length: 351
• Identity: 76/351 - (21%)
• Similarity: 132/351 - (37%)
• Gaps: 29/351 - (8%)

  Fly   593 YRSAIAINPPKALGNLGSV--LSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAA 655
            :..|:.:||......|..|  ...:|||.:|.....|||:..|.....:...|:|....:.|...
Mouse  1397 FNRALTLNPKHYQAYLSRVAYYGLKGRYSKAILNCNEAIKLYPESVRAYICRGVLKYYNRTYKLG 1461

  Fly   656 VECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIE------ILQAGSNLDGAAVRDRTAHDQAR 714
            :.....|||...|...||.|..:.:..:|:.|.|:.      :|.||.|:              .
Mouse  1462 ITDLSTAIKMDKNNYTAYYNRALCYTKIGEHQMALRDYGIVLLLDAGENI--------------A 1512

  Fly   715 SSAYLQLGALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAA 779
            .:..:..|.:|.|..:...||..:::| :.:.|....   |.|.......|:::::.|......|
Mouse  1513 LNTLINRGLIYTELKQYGFALEDFKQA-ALMSGTSVS---LCQATATCHHRIKEFEGAVEFFTRA 1573

  Fly   780 LELQPNQVAAHLSYGITLARNSSRAS--EAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESA 842
            :::.|:.|.|::..|.:....|...:  :|:..|.:||.|.|............|..|.:..::.
Mouse  1574 IKINPHYVDAYIGRGNSYMEYSQEDAMIQAQKDFLKALHLDPSCLKARISLGYNLQAQGKFQKAW 1638

  Fly   843 IYHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTN 907
            |:.....|..|..|......|.....:.....|......|:.:. ..|...||.|.|...:|:..
Mouse  1639 IHFTVGIESNPKSYLAYEGRAVVCLQMSNYFAAMQDINCAIKIN-STAEFLTNRGVIHEFMGQQQ 1702

  Fly   908 HAAASYKAALRLQPGDAITLGNLAKL 933
            .|.|.|:||:.|.|..::...|...:
Mouse  1703 SAMADYQAAISLNPSYSLAYFNAGNI 1728

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468
		TPR	597..852	CDD:440225	56/264 (21%)
		TPR repeat	602..630	CDD:276809	8/29 (28%)
		TPR repeat	635..665	CDD:276809	5/29 (17%)
		TPR repeat	670..694	CDD:276809	6/29 (21%)
		TPR repeat	715..743	CDD:276809	6/27 (22%)
		TPR repeat	748..782	CDD:276809	5/33 (15%)
		TPR	780..>933	CDD:440225	34/154 (22%)
		TPR repeat	787..816	CDD:276809	7/30 (23%)
		TPR repeat	822..850	CDD:276809	3/27 (11%)
		TPR repeat	855..885	CDD:276809	4/29 (14%)
		TPR repeat	890..918	CDD:276809	11/27 (41%)
Ttc6	NP_001299573.1	PTZ00436	<13..178	CDD:185616
		TPR repeat	889..917	CDD:276809
		PEP_TPR_lipo	896..1760	CDD:274350	76/351 (22%)
		TPR repeat	922..952	CDD:276809
		TPR repeat	957..984	CDD:276809
		TPR repeat	990..1017	CDD:276809
		TPR repeat	1023..1051	CDD:276809
		TPR repeat	1056..1086	CDD:276809
		TPR repeat	1162..1189	CDD:276809
		TPR repeat	1194..1224	CDD:276809
		TPR repeat	1229..1257	CDD:276809
		TPR repeat	1268..1292	CDD:276809
		TPR repeat	1299..1325	CDD:276809
		TPR repeat	1341..1369	CDD:276809
		TPR repeat	1374..1403	CDD:276809	1/5 (20%)
		TadD	<1398..1506	CDD:444034	26/107 (24%)
		TPR repeat	1408..1436	CDD:276809	8/27 (30%)
		TPR repeat	1441..1471	CDD:276809	5/29 (17%)
		TPR repeat	1476..1499	CDD:276809	6/22 (27%)
		TPR repeat	1515..1541	CDD:276809	6/26 (23%)
		TPR repeat	1546..1576	CDD:276809	5/32 (16%)
		TPR repeat	1581..1611	CDD:276809	6/29 (21%)
		TPR repeat	1619..1646	CDD:276809	3/26 (12%)
		TPR repeat	1651..1681	CDD:276809	4/29 (14%)
		TPR	1685..>1852	CDD:440225	14/44 (32%)
		TPR repeat	1685..1713	CDD:276809	11/27 (41%)
		TPR repeat	1718..1748	CDD:276809	1/11 (9%)
		TPR repeat	1753..1781	CDD:276809
		TPR repeat	1787..1810	CDD:276809
		TPR repeat	1821..1849	CDD:276809