Protein Alignment Tmtc2 and Tmtc4

DIOPT Version :10

• Sequence 1: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_082927.1
• Gene: Tmtc4 / 70551
• MGIID: 1921050
• Length: 741
• Species: Mus musculus
• Alignment Length: 967
• Identity: 240/967 - (24%)
• Similarity: 367/967 - (37%)
• Gaps: 307/967 - (31%)

  Fly     1 MPSLEPWLWGDSCSWLGMLAMLRLRLHKSNMDFTCLFCCSLAFVLYLNTLGAGFVYDDRRAILAN 65
            :||:.|..|.                 |..:.|..|.|       :..:....||:||..||:.|
Mouse    12 VPSVLPPFWA-----------------KLVVGFVSLLC-------FARSYDGDFVFDDSEAIVNN 52

  Fly    66 ADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLCVLSFRLNYLIGGGFAPWGFHLVNNLLHCVA 130
            .|:...||....:.:||||:.|:.:.||.|:|||.||:||:||.:.|||.|.|||:||.|||...
Mouse    53 KDLQSDTPLGDLWHHDFWGSKLSSNTSHKSYRPLTVLTFRINYYLSGGFHPVGFHVVNILLHGSI 117

  Fly   131 TALVVRVARTLLASVW-------------AVLAAGALFAAHPIHTEAVAGVVGRADLAACVCYLL 182
            :.|::.|...|...:.             |.|.|..|||.||:|||.||||||||||...:.:||
Mouse   118 SILMLDVFSVLFGGLQYTGKGQRVHLAPRASLLATLLFAVHPVHTECVAGVVGRADLLCALFFLL 182

  Fly   183 TYLSYLRHMRWRESGDPRQ------WLALGATLILAAAGLLCKETAITALLVCALFDVMRGLSGQ 241
            ::|.|.:  .::|:|:...      |:.|  ::.|.|..:||||..||.|.:.|:||::  :.|:
Mouse   183 SFLGYCQ--AFKETGNKEGTHSSTFWVLL--SIFLGAVAMLCKEQGITVLGLNAVFDIL--VIGK 241

  Fly   242 VDKQRLRSVCIVL---------------GALF----------CMAYCRLVIVPGPQTAFSSADNP 281
            :|  .|.:|..||               |.||          .|.|.|..|:.....||:..|||
Mouse   242 LD--ILAAVRKVLHKDKSQENAGMFKNGGLLFRIALLTIGGTSMLYIRWKIMGTGPPAFTEVDNP 304

  Fly   282 IARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVA 346
            .:...|...|.:.:.|....|..|||.|..|.|||.|..:|.:.|:.|.|....|..:..|:|:
Mouse   305 ASFADSMLVRAINYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGL- 368

  Fly   347 WGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALP 411
                                                                             
Mouse   369 ----------------------------------------------------------------- 368

  Fly   412 CRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSS 476
                                             .|:...|..||...
Mouse   369 ---------------------------------IFQALCSEDSCKRR------------------ 382

  Fly   477 SSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVG 541
                                       :|.:.|.||.:||||||||.|.||||||||:|||||.|
Mouse   383 ---------------------------ILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAG 420

  Fly   542 FCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINP--PKA 604
            :|:|:.:|...|....::.:.:..:...:|| ..:||.:.|:.:||.||.|:|||:::.|  .|.
Mouse   421 YCVLLTFGFGALSRHTKKKKPVAAIILGILL-INALRCVIRSGEWRSEEQLFRSALSVCPLNAKV 484

  Fly   605 LGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKFRPNL 669
            ..|:|..|:.||....|.:..:||:|..|.......|||.:.:.:.....|.|....|::.:|:.
Mouse   485 HYNIGKNLADQGNQTAAIKYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDF 549

  Fly   670 AVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRA 734
            |.|::||||
Mouse   550 AAAWMNLGI-------------------------------------------------------- 558

  Fly   735 LAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSYGITLAR 799
                                       |...|::::|||:.:|.|::.:......:.:.|...|.
Mouse   559 ---------------------------VQNSLKRFEEAEQSYRTAIKHRRKYPDCYYNLGRLYAD 596

  Fly   800 NSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYTLVVAAAT 864
            .:........| :.|..|.||.:..:::....|.......::....|.|.:|.|||::|:.:.|.
Mouse   597 LNRHVDALNAW-RNATVLKPEHSLAWNNMIILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLAN 660

  Fly   865 AMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQP 921
            .:....:..::|..:.||:...|..|..|.||..:.|..|..:.|...|:.:|:|.|
Mouse   661 VLGKSQKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGHLDSAKKHYEISLQLDP 717

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468	23/72 (32%)
		TPR	597..852	CDD:440225	42/256 (16%)
		TPR repeat	602..630	CDD:276809	9/27 (33%)
		TPR repeat	635..665	CDD:276809	6/29 (21%)
		TPR repeat	670..694	CDD:276809	6/23 (26%)
		TPR repeat	715..743	CDD:276809	0/27 (0%)
		TPR repeat	748..782	CDD:276809	7/33 (21%)
		TPR	780..>933	CDD:440225	31/142 (22%)
		TPR repeat	787..816	CDD:276809	4/28 (14%)
		TPR repeat	822..850	CDD:276809	3/27 (11%)
		TPR repeat	855..885	CDD:276809	6/29 (21%)
		TPR repeat	890..918	CDD:276809	8/27 (30%)
Tmtc4	NP_082927.1	TMTC_DUF1736	292..366	CDD:462468	23/73 (32%)
		TPR	475..681	CDD:440225	51/289 (18%)
		TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	482..515		11/32 (34%)
		TPR repeat	482..510	CDD:276809	9/27 (33%)
		TPR repeat	515..545	CDD:276809	6/29 (21%)
		TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	516..549		7/32 (22%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	550..583		13/115 (11%)
		TPR repeat	550..578	CDD:276809	13/110 (12%)
		TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	584..617		6/33 (18%)
		TPR repeat	584..610	CDD:276809	3/26 (12%)
		TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	618..651		5/32 (16%)
		TPR repeat	618..646	CDD:276809	3/27 (11%)
		TPR	645..>738	CDD:440225	21/73 (29%)
		TPR repeat	651..681	CDD:276809	6/29 (21%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	652..685		6/32 (19%)
		TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	686..719		11/32 (34%)
		TPR repeat	686..714	CDD:276809	8/27 (30%)