DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and kdm6a

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_005167851.1	Gene:	kdm6a / 569277	ZFINID:	ZDB-GENE-081105-56	Length:	1452	Species:	Danio rerio

Alignment Length:	509	Identity:	99/509 - (19%)
Similarity:	172/509 - (33%)	Gaps:	163/509 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   556 CNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINPPKALG------NLGSVLSS 614
            |..|.:.|     .|.|..|    .:.|.|:......::.|:..:.|..|.      ::..|...
Zfish   179 CFSRAKEI-----HLRLGLM----FKVNTDYESSLKHFQLALIDSTPCTLSKAEIQFHIAHVYEI 234

  Fly   615 QGRYEEAKQVLQEAIRFRPNMADVHF----NLGILHQ---------NQQVYPAAVECFQRAIKFR 666
            |.:|..||:..:..::.....|.|..    .||.:|.         |:..|  |::|.|::::..
Zfish   235 QKKYRIAKEAYESLLQTENLPAQVKATTLQQLGWMHHTVEQLGDKANKNSY--AIQCLQKSLEAD 297

  Fly   667 PNLAVAYLNLGISFIALGKRQQA--------------------IEILQAGSNLDGAAVRDRTAH- 710
            ||...::..||..:.::||.|.|                    |.:|....|....|::   |:
Zfish   298 PNSGQSWYFLGRCYSSIGKVQDAFISYRQSIDKSEASADTWCSIGVLYQQQNQPMDALQ---AYI 359

  Fly   711 -----DQARSSAYLQLGALYVEQGKLQRALAIY-----REALSSLPGLPQQREILYQRIGDVLGR 765
                 |.:.::|::.||.||....:.|.|:..|     .::.|::|.|..:.:.|..:    |..
Zfish   360 CAVQLDHSHAAAWMDLGTLYESCNQPQDAIKCYINATCSKSCSNIPALTARIKCLQAQ----LCN 420

  Fly   766 LQQ----------------WD-----------------------EAERHHRAALELQPNQVAAHL 791
            |||                |.                       :|.:.:.|..::....:..|:
Zfish   421 LQQGSLPSKSKMLPSIEEAWSLPIPAELTSRQGALNTTQQQTTCKAHQSNEAQSQIPSQSLPPHV 485

  Fly   792 SYGITLARNSSRASEAEMWFKRALKLAPEQASVY-----HHYAEFLSL---------QSRHHESA 842
            ..|.|    ..::|.|:.  ||....|...:..:     ||.....||         |.|::.
Zfish   486 LSGQT----EDQSSPAKK--KRTTSPARNSSDSWTNDPGHHQISNWSLTPQKLQLLEQLRNNR-- 542

  Fly   843 IYHRRAAELAPNDYTLVVAAATAMRLLDR----KVDAEMWYRKAVALRP-GDAHAHTNLGAI--- 899
                  |.|.|....::......:.|:.:    :::|....|.:|:..| .|:...||..:.
Zfish   543 ------ANLKPVQLQMLEQLEKQLSLMQQNQQTRLNAMGQIRPSVSNGPVADSSLPTNSNSTPSP 601

  Fly   900 --LHL-LGRTNHAAASYKAALRLQP-------------GDAITLGNLAKLGVTN 937
              .|: |.||..|.....|    ||             ..|.||||...:.|.|
Zfish   602 HHPHIALSRTPSALTRCAA----QPIANGPVPASPVPCSTAGTLGNTDAVSVGN 651

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453
		DUF1736	275..343	CDD:285594
		TPR_11	602..667	CDD:290150	17/83 (20%)
		TPR_1	602..634	CDD:278916	7/37 (19%)
		TPR repeat	602..630	CDD:276809	7/33 (21%)
		TPR repeat	635..665	CDD:276809	10/42 (24%)
		TPR_11	636..700	CDD:290150	21/96 (22%)
		TPR_1	636..668	CDD:278916	10/44 (23%)
		TPR repeat	670..694	CDD:276809	7/43 (16%)
		TPR_11	714..784	CDD:290150	19/113 (17%)
		TPR repeat	715..743	CDD:276809	8/32 (25%)
		TPR repeat	748..782	CDD:276809	9/72 (13%)
		TPR_11	755..819	CDD:290150	15/102 (15%)
		TPR repeat	787..816	CDD:276809	7/28 (25%)
		TPR_11	821..887	CDD:290150	13/83 (16%)
		TPR repeat	822..850	CDD:276809	6/41 (15%)
		TPR repeat	855..885	CDD:276809	4/33 (12%)
		TPR_11	<874..921	CDD:290150	13/53 (25%)
		TPR repeat	890..918	CDD:276809	8/33 (24%)
kdm6a	XP_005167851.1	TPR	74..332	CDD:223533	34/163 (21%)
		TPR repeat	95..123	CDD:276809
		TPR repeat	131..176	CDD:276809
		TPR repeat	181..211	CDD:276809	7/38 (18%)
		TPR repeat	222..250	CDD:276809	5/27 (19%)
		TPR repeat	260..295	CDD:276809	8/36 (22%)
		TPR_17	289..320	CDD:290167	9/30 (30%)
		TPR_11	302..365	CDD:290150	11/65 (17%)
		TPR repeat	302..329	CDD:276809	6/26 (23%)
		TPR repeat	334..364	CDD:276809	5/32 (16%)
		TPR_1	335..368	CDD:278916	6/35 (17%)
		TPR repeat	369..395	CDD:276809	8/25 (32%)
		SSDP	572..852	CDD:282372	22/84 (26%)
		JmjC	1149..1213	CDD:214721
		JmjC	1183..1291	CDD:202224
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900