Protein Alignment Tmtc2 and tmtc2a

DIOPT Version :10

• Sequence 1: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_001124075.1
• Gene: tmtc2a / 564667
• ZFINID: ZDB-GENE-041210-299
• Length: 844
• Species: Danio rerio
• Alignment Length: 933
• Identity: 366/933 - (39%)
• Similarity: 498/933 - (53%)
• Gaps: 142/933 - (15%)

  Fly    36 LFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLC 100
            |.|.::|.:||:|||.|.|.|||.|||..|.|:...|||.....:|||||.||.||||.|:||||
Zfish     5 LVCSAVALLLYMNTLSADFCYDDSRAIKTNQDLLPDTPWTNILYDDFWGTLLTHSGSHKSFRPLC 69

  Fly   101 VLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLL-ASVWAVLAAGALFAAHPIHTEA 164
            .:||||||.: ||..|:||||.|..|||..|||.....|.|| ...|::| ||.|||:|||||||
Zfish    70 TISFRLNYFL-GGLDPYGFHLFNVGLHCCVTALFTAFCRPLLGGGPWSLL-AGLLFASHPIHTEA 132

  Fly   165 VAGVVGRADLAACVCYLLTYLSY-----LRH-------MRWRESGDPRQWLA--LGATLILAAAG 215
            |||||||||:.|..|:||:.|.|     |||       :.||..    .|||  |||    |||.
Zfish   133 VAGVVGRADVGAAFCFLLSLLCYSQYCRLRHNAAHSSRVAWRAG----SWLAGSLGA----AAAA 189

  Fly   216 LLCKETAITALLVCALFDVMRGLSGQVDKQRLRSVCIVL------GALFCMAY----------CR 264
            ||.||..:|.|.|.|::||.     .|.:.|||...|||      ..|..:|:          .|
Zfish   190 LLWKEQGVTVLAVSAVYDVC-----VVHRLRLRQALIVLLKRKNRSLLVSLAWLVGWGIILLTAR 249

  Fly   265 LVIVPGPQTAFSSADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWD 329
            ...:......||::|||.|.:|...||.|||||||..|..|||.|:.|||||.|||:|.:.|:.|
Zfish   250 FHWMGNKPPNFSNSDNPAADSPHFLTRALTFLYLPSVNAWLLLCPDKLSFDWSMDAVPLLKSIAD 314

  Fly   330 RRNAQSACFYSVLVGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTK 394
            .||.||..|||....:||.|.|.                 |.....|:
Zfish   315 WRNLQSVMFYSGFALLAWFSLRN-----------------PPLQATKI----------------- 345

  Fly   395 YQAFEAAYHQQQQEALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNST 459
                                 |.:|...:|                     ..|..:::.||:..
Zfish   346 ---------------------NESNGKSHV---------------------SNGKYATNGCSHKH 368

  Fly   460 NSSSSSSSSSSSSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLF 524
            |.:.....:..|:...:.||    :.|.|..      ||..  .|::.||..|.|||:||:||.|
Zfish   369 NDNHYRDLNLKSNGYHNKSL----KVSQKTL------PATE--SVVVFSLGLLVLPFIPATNLFF 421

  Fly   525 YVGFVVAERLLYLPSVGFCLLVGYGVSKL-MSCNQRTRNILLLSFSL-LLAAMSLRTLRRNADWR 587
            |||||||||:||:||:||||||..||..| :.|..::...|||:.:. |:...||:|:|||.||:
Zfish   422 YVGFVVAERVLYIPSMGFCLLVTAGVRSLFVRCRSKSFRALLLTCTAGLVLLYSLKTVRRNQDWK 486

  Fly   588 DEESLYRSAIAINPPKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVY 652
            .||.||||.||:||.||.||||:||.:||:..||::..:.|:.:|.||||:.:|||:|.|..:.:
Zfish   487 SEEMLYRSGIAVNPAKAWGNLGNVLKNQGKMAEAERAYRNALYYRGNMADMLYNLGLLLQENERF 551

  Fly   653 PAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSA 717
            ..|:..::.||..||.||.||||:||..::.|..::|.......:::....::|..||..:.:|.
Zfish   552 SEALHYYKLAIGSRPTLASAYLNVGIILVSQGNIEEAKRTFHTCADIPDENLKDPHAHKSSVTSC 616

  Fly   718 YLQLGALYVEQGKLQRALAIYREALSSLPG--LPQQREILYQRIGDVLGRLQQWDEAERHHRAAL 780
            ...||.|..:||:.:.||::|:||:..:|.  .||.   ||..:|:...||...:||...:|.:|
Zfish   617 LYNLGKLLHDQGQHEEALSVYKEAVRKMPRQFAPQS---LYNMMGEAYMRLNILEEAGHWYRESL 678

  Fly   781 ELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYH 845
            :.:|:.:.|||:||..|:....: ||||.:|.:|::|.|.:.:.|.||.:||..:||..|:|...
Zfish   679 KAKPDHIPAHLTYGKLLSIMGQK-SEAERYFLKAIELDPARGNCYMHYGQFLLEESRLAEAAAMA 742

  Fly   846 RRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAA 910
            ::||||...::.:|.:||..:|......:||.:|.||..|||....|..||||||||.|:...|.
Zfish   743 QKAAELDNEEFDVVFSAAHMLRQASLNEEAETYYGKAADLRPDHPAALMNLGAILHLNGKLKEAE 807

  Fly   911 ASYKAALRLQPGDAITLGNLAKL 933
            ::|..||:|:|.|.||..||.||
Zfish   808 SNYLRALQLKPDDLITQSNLHKL 830

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468	39/72 (54%)
		TPR	597..852	CDD:440225	95/256 (37%)
		TPR repeat	602..630	CDD:276809	13/27 (48%)
		TPR repeat	635..665	CDD:276809	11/29 (38%)
		TPR repeat	670..694	CDD:276809	9/23 (39%)
		TPR repeat	715..743	CDD:276809	11/27 (41%)
		TPR repeat	748..782	CDD:276809	11/33 (33%)
		TPR	780..>933	CDD:440225	62/152 (41%)
		TPR repeat	787..816	CDD:276809	12/28 (43%)
		TPR repeat	822..850	CDD:276809	10/27 (37%)
		TPR repeat	855..885	CDD:276809	9/29 (31%)
		TPR repeat	890..918	CDD:276809	13/27 (48%)
tmtc2a	NP_001124075.1	TMTC_DUF1736	254..328	CDD:462468	39/73 (53%)
		TPR repeat	501..529	CDD:276809	13/27 (48%)
		LapB	504..815	CDD:442196	115/314 (37%)
		TPR repeat	534..564	CDD:276809	11/29 (38%)
		TPR repeat	569..597	CDD:276809	9/27 (33%)
		TPR repeat	603..642	CDD:276809	14/38 (37%)
		TPR repeat	653..679	CDD:276809	8/25 (32%)
		TPR repeat	684..714	CDD:276809	12/30 (40%)
		TPR repeat	787..815	CDD:276809	13/27 (48%)