DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4341 and IFIT1B

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001010987.1	Gene:	IFIT1B / 439996	HGNCID:	23442	Length:	474	Species:	Homo sapiens

Alignment Length:	396	Identity:	73/396 - (18%)
Similarity:	138/396 - (34%)	Gaps:	126/396 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   484 QCSSKDY---------ALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPS 539
            :|..|:|         |||| :|.|                  |..|
Human   151 KCGGKNYERAKTCFEKALEG-NPEN------------------PEFN------------------ 178

  Fly   540 VGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAI----- 599
            .|:.:.| |.:.|..:.:.|.:            |.||..|:|......::...|..:|:
Human   179 TGYAITV-YRLDKFNTASGRNK------------AFSLHVLKRAVRLNPDDVYIRVLLALKLQDE 230

  Fly   600 ----NPPKALGNLGSVLSSQ--------------GRYEEAKQVLQEAIRFRPNMADVHFNLGILH 646
                ...|.:....:.:|||              |..::|.::|:.|:...|..|.:|..:|:.:
Human   231 GQEAEGEKYIEEALTSISSQAYVFQYAAKFYRRKGSVDKALELLKMALETTPTSAFLHHQMGLCY 295

  Fly   647 QNQQV---------------------YPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAI 690
            :.|.:                     ...|:..|::.|..:....:||::|..::..:|..::|.
Human   296 RAQMIQIKEATNWQPRGQDRETVDRLVQLAICKFEKTIMLKRTFEMAYVDLAETYAEIGHHRKAE 360

  Fly   691 EILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQ-RALAIYREALSSLPGLPQQREI 754
            |..|.|       :|.:...||.:...:...|......||.| :|:..|.:.| .:..:...||.
Human   361 EHFQKG-------LRMKIFEDQLKQEIHYHYGRFQEHHGKSQDKAITHYLKGL-KIEKMSHSREK 417

  Fly   755 LYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLAP 819
            |       |..|::..:...|       |..:|...:|....:.:.....|:|.:.::|||:||.
Human   418 L-------LNALEKLAKRCIH-------QNVRVVESVSLLGLIHKLKGEVSDALLCYERALRLAA 468

  Fly   820 EQASVY 825
            :...::
Human   469 DLNPIF 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453
		DUF1736	275..343	CDD:285594
		TPR_11	602..667	CDD:290150	16/99 (16%)
		TPR_1	602..634	CDD:278916	8/45 (18%)
		TPR repeat	602..630	CDD:276809	8/41 (20%)
		TPR repeat	635..665	CDD:276809	7/50 (14%)
		TPR_11	636..700	CDD:290150	15/84 (18%)
		TPR_1	636..668	CDD:278916	7/52 (13%)
		TPR repeat	670..694	CDD:276809	6/23 (26%)
		TPR_11	714..784	CDD:290150	13/70 (19%)
		TPR repeat	715..743	CDD:276809	6/28 (21%)
		TPR repeat	748..782	CDD:276809	6/33 (18%)
		TPR_11	755..819	CDD:290150	13/63 (21%)
		TPR repeat	787..816	CDD:276809	6/28 (21%)
		TPR_11	821..887	CDD:290150	0/5 (0%)
		TPR repeat	822..850	CDD:276809	0/4 (0%)
		TPR repeat	855..885	CDD:276809
		TPR_11	<874..921	CDD:290150
		TPR repeat	890..918	CDD:276809
IFIT1B	NP_001010987.1	TPR_11	36..>298	CDD:330823	35/196 (18%)
		TPR 1	52..85
		TPR repeat	54..80	CDD:276809
		TPR 2	95..128
		TPR repeat	97..123	CDD:276809
		TPR repeat	128..170	CDD:276809	5/18 (28%)
		TPR 3	139..174		8/23 (35%)
		TPR 4	182..216		9/46 (20%)
		TPR repeat	216..246	CDD:276809	3/29 (10%)
		TPR 5	251..284		5/32 (16%)
		TPR repeat	251..279	CDD:276809	4/27 (15%)
		TPR repeat	284..335	CDD:276809	7/50 (14%)
		TPR_11	<323..469	CDD:330823	37/167 (22%)
		TPR 6	340..373		9/39 (23%)
		TPR repeat	340..368	CDD:276809	8/34 (24%)
		TPR 7	378..412		7/34 (21%)
		TPR repeat	378..407	CDD:276809	7/29 (24%)
		TPR 8	437..470		8/32 (25%)
		TPR repeat	437..465	CDD:276809	5/27 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810