DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc2 and Tmtc4

DIOPT Version :10

Sequence 1:NP_608558.1 Gene:Tmtc2 / 33276 FlyBaseID:FBgn0028481 Length:938 Species:Drosophila melanogaster
Sequence 2:NP_650451.1 Gene:Tmtc4 / 41867 FlyBaseID:FBgn0038324 Length:705 Species:Drosophila melanogaster


Alignment Length:954 Identity:256/954 - (26%)
Similarity:375/954 - (39%) Gaps:303/954 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 MLRLRLHKSNMD---------FTCLFC--CSLAFVLYLNTLGAGFVYDDRRAILANADVSG-GTP 73
            ||.| :||:.:.         ..||.|  |.       ...||.||:||..||:.|.||:. .|.
  Fly     1 MLDL-VHKATLHSMVCQAILVLICLLCYGCG-------GLSGAKFVFDDTVAIVKNRDVNSLPTN 57

  Fly    74 WQRSFSNDFWGTPLTDSGSHGSWRPLCVLSFRLNY-LIGGGFAPWGFHLVNNLLHCVATALVVRV 137
            |...|::||||..|..|.||.|:|||..|.|...| |:|...|...|  :|.|||||.|.|:.|:
  Fly    58 WTAIFTHDFWGASLLSSDSHKSFRPLTTLMFHCEYALLGLSAAHMKF--LNLLLHCVNTLLMWRL 120

  Fly   138 ARTLL-----ASVWAVLAAGALFAAHPIHTEAVAGVVGRADL----AACVCYLLTYLSYLRHMRW 193
            .|:|.     .:.||:|:| |||||||||||||:||||||:|    ...:|.|||..:..|  ..
  Fly   121 IRSLYVPEVSTARWAILSA-ALFAAHPIHTEAVSGVVGRAELMFGMIHLLCLLLTVANTGR--LG 182

  Fly   194 RESGDPRQWLALGATLILAAAGLLCKETAITALLVCALFDVMRGLSG----------QVDKQRLR 248
            .::|        |..::|.|.|:|.||:|:|..:.|.|.|..:  :|          .:.:.|:.
  Fly   183 PQTG--------GLIMLLTAVGMLFKESAVTIPMSCVLLDYFQ--NGYYHLRFKDQWSLLRTRIS 237

  Fly   249 SVCIVLGALFCMAYCRLVIVPGPQTAFSSADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLS 313
            .:..:||.|..:. .||.........|...|||:|......||.|:..||.|.|:.|:|.|:.|.
  Fly   238 YLFYLLGTLGLLT-ARLWWQDFETPTFKEVDNPVAHNEHVLTRGLSQQYLLVMNIWLMLCPHWLC 301

  Fly   314 FDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVA 378
            :||.:..:..||::||.|......|||:::                                 ||
  Fly   302 YDWALGCVKLVTNIWDLRLQGVIGFYSIVL---------------------------------VA 333

  Fly   379 SRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVS 443
                      |.|                                                    
  Fly   334 ----------LMN---------------------------------------------------- 336

  Fly   444 SAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMS 508
              ||                                           .|.||          :::
  Fly   337 --FR-------------------------------------------RLPGM----------MLA 346

  Fly   509 LSFLALPFLPASNLLFYVGFVVAERLLYLPSVGFCLLVGYGV-----SKLMSCNQRTR-NILLLS 567
            |..:.:||||||.:: .||||:|||.||:||:|||||..||.     |...:.:.||. .|||: 
  Fly   347 LGLMIVPFLPASGII-CVGFVIAERTLYVPSIGFCLLSIYGFLYWYDSSTENTHWRTALRILLM- 409

  Fly   568 FSLLLAAMSLRTLRRNADWRDEESLYRSAIAINP--PKALGNLGSVLSSQGRYEEAKQVLQEAIR 630
              ||.:.|.:||.:|..||.:||.|::||:.:.|  .|...|:..:.:..|...:|.|....||.
  Fly   410 --LLFSVMMVRTRQRATDWLNEEQLFKSALQVCPDNAKVHYNIARLATDMGNNTKAFQHYHRAIE 472

  Fly   631 FRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQA 695
            ..||......|||.|::.......|.|..:.|::..|....|::|||              |:|:
  Fly   473 LYPNYESALMNLGNLYREHGQLSTAEEYIRLALQAYPAFPAAWMNLG--------------IVQS 523

  Fly   696 GSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIG 760
            .                               |||..:|||.|.:||......    .:.|..:|
  Fly   524 A-------------------------------QGKYDKALASYEKALKYRANF----AVCYYNMG 553

  Fly   761 DVLGRLQQWDEAERHHRAALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLAPEQASVY 825
            ::....:::.||..|.:.|:.|.|.|..|..:. :|:..|.....:       ||:::       
  Fly   554 NLYLEQKRYAEALHHWQHAVALNPRQPKAWANI-LTMLDNKGLQDD-------ALRIS------- 603

  Fly   826 HHYAEFLSLQSRHHESAIYHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVALRPGDA 890
                          ..|:.|      .|||.:::...|..:..|....:||..|::.:.|.|.:.
  Fly   604 --------------NQALQH------LPNDVSILFIRANVLGKLKHYTEAEAIYKRVIELEPHNT 648

  Fly   891 HAHTNLGAILHLLGRTNHAAASYKAALRLQPGDAITL-GNLAKL 933
            ..|||||.:.|...:|..|..:|:.|:.:....|.|. .||:||
  Fly   649 LYHTNLGVLYHRWDKTQEAIEAYRTAISISAARATTARENLSKL 692

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc2NP_608558.1 TMTC_DUF1736 270..343 CDD:462468 26/72 (36%)
TPR 597..852 CDD:440225 49/256 (19%)
TPR repeat 602..630 CDD:276809 6/27 (22%)
TPR repeat 635..665 CDD:276809 7/29 (24%)
TPR repeat 670..694 CDD:276809 5/23 (22%)
TPR repeat 715..743 CDD:276809 8/27 (30%)
TPR repeat 748..782 CDD:276809 6/33 (18%)
TPR 780..>933 CDD:440225 34/153 (22%)
TPR repeat 787..816 CDD:276809 4/28 (14%)
TPR repeat 822..850 CDD:276809 2/27 (7%)
TPR repeat 855..885 CDD:276809 6/29 (21%)
TPR repeat 890..918 CDD:276809 10/27 (37%)
Tmtc4NP_650451.1 TMTC_DUF1736 258..331 CDD:462468 26/72 (36%)
LapB 431..675 CDD:442196 71/327 (22%)
TPR repeat 444..472 CDD:276809 6/27 (22%)
TPR repeat 480..506 CDD:276809 7/25 (28%)
TPR repeat 511..541 CDD:276809 15/74 (20%)
TPR repeat 546..574 CDD:276809 6/27 (22%)
TPR repeat 580..608 CDD:276809 6/56 (11%)
TPR repeat 614..642 CDD:276809 5/27 (19%)
TPR repeat 647..677 CDD:276809 10/29 (34%)

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