DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4341 and odad4

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_956610.1	Gene:	odad4 / 393286	ZFINID:	ZDB-GENE-040426-995	Length:	486	Species:	Danio rerio

Alignment Length:	488	Identity:	93/488 - (19%)
Similarity:	148/488 - (30%)	Gaps:	208/488 - (42%)

- Green bases have known domain annotations that are detailed below.

  Fly   609 GSVLSSQGRYEEAKQVLQEAIRFRPN---------------------MADVHFNL--------GI 644
            |..|..:|.|.:|.:....|:..:|:                     :.|...:|        |:
Zfish    21 GDQLFQRGEYVKAVESFTTALTLQPDNKNCLVSRSRCYVKLGDAENALKDAESSLKDNKNYFKGL 85

  Fly   645 LHQNQQVYPA-----AVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIE----------ILQ 694
            ..:.:.:|..     |:..:.|..|.||.|  ....|||.     |.|:||:          ::.
Zfish    86 YQKAEALYTMGDFEFALVYYHRGHKLRPEL--QEFRLGIQ-----KAQEAIDNSVGSPSSVKLVN 143

  Fly   695 AG-----------SNLDGAAVRDRTAH----DQARSSAYLQLGALYVEQGKLQRAL--------- 735
            .|           .||:.:..::...|    |:...:|...||.||.::..|::.|
Zfish   144 KGDLSFFHNGVHPQNLNPSNKKESKKHSKKTDKGEKTAKQLLGELYSDREYLKKLLQDEDLVKCK 208

  Fly   736 -----------------------------AIY-------------------------REALSSL- 745
                                         .||                         |..||||
Zfish   209 IRSGERVQDLIVGSISYLDTRMAFWQQQKPIYARQRDRKLMQQQWSKVLHKPPSDPTRYVLSSLE 273

  Fly   746 ------------------------------PGLPQQREI---LYQRIGDVLGRLQQWDEAERHHR 777
                                          ..||.:.|:   |:..||:.|..|...|.|..||.
Zfish   274 EIDTALSAGYTESGLNKARELMKVVKDWSEDALPNKNEVLGNLHSYIGNALMDLGNMDRALHHHE 338

  Fly   778 AALE------LQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLA---PEQASVYHHYAE-FL 832
            ..||      |..::..|..:.|...||........|:|.|: |.||   .|:|.::|.... :|
Zfish   339 KDLELAKKCDLTDSKSRALDNIGRVYARIGKFQQAIEVWEKK-LPLACGGLEKAWLFHEIGRCYL 402

  Fly   833 SLQSRHHESAIYHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNL- 896
            .|: |:.|:..|..|:. :|.:|                 :..|.|...|..|.   |.|...|
Zfish   403 ELK-RYMEARDYGSRSL-MAADD-----------------ISDEKWQLNASVLM---AQAELKLS 445

  Fly   897 ---GAILHL--------LGRTNHAAASYKAALR 918
               .::||.        |.:.:.|:.:.:.|||
Zfish   446 NYKASVLHFERALERAKLLQDDSASEAIQKALR 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453
		DUF1736	275..343	CDD:285594
		TPR_11	602..667	CDD:290150	14/91 (15%)
		TPR_1	602..634	CDD:278916	6/24 (25%)
		TPR repeat	602..630	CDD:276809	6/20 (30%)
		TPR repeat	635..665	CDD:276809	6/42 (14%)
		TPR_11	636..700	CDD:290150	19/97 (20%)
		TPR_1	636..668	CDD:278916	8/44 (18%)
		TPR repeat	670..694	CDD:276809	7/33 (21%)
		TPR_11	714..784	CDD:290150	29/172 (17%)
		TPR repeat	715..743	CDD:276809	10/90 (11%)
		TPR repeat	748..782	CDD:276809	14/42 (33%)
		TPR_11	755..819	CDD:290150	22/72 (31%)
		TPR repeat	787..816	CDD:276809	7/28 (25%)
		TPR_11	821..887	CDD:290150	14/66 (21%)
		TPR repeat	822..850	CDD:276809	8/28 (29%)
		TPR repeat	855..885	CDD:276809	4/29 (14%)
		TPR_11	<874..921	CDD:290150	14/57 (25%)
		TPR repeat	890..918	CDD:276809	8/39 (21%)
odad4	NP_956610.1	TPR 1. /evidence=ECO:0000255	14..47		7/25 (28%)
		TPR_11	16..79	CDD:290150	9/57 (16%)
		TPR repeat	16..42	CDD:276809	6/20 (30%)
		TPR repeat	47..77	CDD:276809	2/29 (7%)
		TPR 2. /evidence=ECO:0000255	49..81		2/31 (6%)
		TPR_11	50..113	CDD:290150	7/62 (11%)
		TPR 3. /evidence=ECO:0000255	82..115		7/32 (22%)
		TPR repeat	82..110	CDD:276809	4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	153..180		4/26 (15%)
		TPR_12	313..379	CDD:290160	18/65 (28%)
		TPR 4. /evidence=ECO:0000255	314..347		11/32 (34%)
		TPR repeat	316..342	CDD:276809	9/25 (36%)
		TPR repeat	347..383	CDD:276809	9/36 (25%)
		TPR 5. /evidence=ECO:0000255	354..387		10/33 (30%)
		TPR_12	355..423	CDD:290160	20/70 (29%)
		TPR 6. /evidence=ECO:0000255	391..424		10/51 (20%)
		TPR 7. /evidence=ECO:0000255	431..464		7/35 (20%)
		TPR repeat	431..459	CDD:276809	7/30 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.900