DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and Tmtc1

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_945318.2	Gene:	Tmtc1 / 387314	MGIID:	3039590	Length:	942	Species:	Mus musculus

Alignment Length:	1088	Identity:	295/1088 - (27%)
Similarity:	421/1088 - (38%)	Gaps:	401/1088 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 YLNTLGAGFVYDDRRAILANADVSGGTP--WQRSFSNDFWGTPLTDSGSHGSWRPLCVLSFRLNY 108
            |..:|...||:||..||:.|.||..|||  | ..|:|||||..|.||.||.|:|||||||||||.
Mouse    40 YGRSLRGEFVHDDVWAIVNNPDVRPGTPLRW-AIFANDFWGKGLADSTSHKSYRPLCVLSFRLNI 103

  Fly   109 LIGGGFAPWGFHLVNNLLHCVAT-ALVVRVARTLLASVWAVLAAGALFAAHPIHTEAVAGVVGRA 172
            .: .|..|:.||.||.:|||:.| .|:....:|:..:.........|||.||:|||||||:||||
Mouse   104 FL-TGMNPFYFHAVNVILHCLVTLVLMYTCDKTVFKNRGLAFVTALLFAVHPVHTEAVAGIVGRA 167

  Fly   173 DLAACVCYLLTYLSYLRHMRWRESGDPRQWLALGA-------TLILAAAGLLCKETAITALLVCA 230
            |:.||:.:||.:|||.|.:   :.|...|.....|       :|.|....:|.|||.||...||.
Mouse   168 DVLACLLFLLAFLSYQRSL---DQGCAGQCFPTTASPFFLLLSLFLGTCAMLVKETGITVFGVCL 229

  Fly   231 LFD-------------------------------------------------------------- 233
            ::|
Mouse   230 VYDLFSPSHKQDKLSNGAVCQHSSGQPGSPQPSSQQAHPHRESRKQRFPHKDSWGGCHSPLPPEP 294

  Fly   234 --------------VMRGLSGQVDKQ-------RLRSVCIVLGALFCMAYCRLVIVPGPQTAFSS 277
                          :||.|:|..::.       .|:...:|:..:..:.|.||.|:.|....||.
Mouse   295 KSSGFPMSPRAMWSLMRCLTGSTNRNFLLTLRPFLKRAILVISYVTVILYFRLWIMGGTMPLFSE 359

  Fly   278 ADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVL 342
            .|||.:.:|...||.||:.||..||:.|||.|..|.:||.:.::|.|.::||.||     ..::|
Mouse   360 QDNPASFSPYILTRFLTYSYLLAFNVWLLLAPITLCYDWQVGSIPLVETIWDVRN-----LATIL 419

  Fly   343 VGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQ 407
            :.|...    |||     .||             ||                  ||:...|::
Mouse   420 LAVVMA----LLS-----LHC-------------VA------------------AFKRLEHKE-- 442

  Fly   408 EALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSS 472

Mouse   443 ----------------------------------------------------------------- 442

  Fly   473 SSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYL 537
                                            ::..|.||..||:|||||.|.||||||||:||:
Mouse   443 --------------------------------VLAGLLFLVFPFIPASNLFFRVGFVVAERVLYM 475

  Fly   538 PSVGFCLLVGYGVSKLMSCNQRTR---NILLLSFSLLLAAMSLRTLRRNADWRDEESLYRS---- 595
            ||:|:|:|..:|:|||  |...:|   ..|:.|..|||...|.:|:::|..|...|||:||
Mouse   476 PSMGYCILFVHGLSKL--CAGLSRCGATSLMASTVLLLLLFSWKTVKQNEIWLSRESLFRSGVQT 538

  Fly   596 -------------------------------------------------------------AIAI 599
                                                                         |:.:
Mouse   539 LPHNAKVHYNYANFLKDQGRNKEAIYHYRTALKLYPRHASALNNLGTLTKDMAEAKMYYQKALQL 603

  Fly   600 NPP--KALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNL-------------------G 643
            :|.  :||.|||::|.||.:.|||..:|:|:|::.|:.||.:.:|                   |
Mouse   604 HPQHNRALFNLGNLLKSQEKTEEAIMLLKESIKYGPDFADAYSSLASLLAEQERFKEAEDIYQAG 668

  Fly   644 I--------LHQNQQVY-------PAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEIL 693
            |        ||.|..|:       ..||..:|:||:..|:..||.:|||..:.:||:..:|.|..
Mouse   669 IKNCPDSSDLHNNYAVFLVDSGFPEKAVAHYQQAIQLSPSHHVAVVNLGRLYRSLGENSKAEEWY 733

  Fly   694 QAGSNLDGAAVRDRTAHDQARSSAYLQ-LGALYVEQGKLQRALAIYREALSSLPGLPQQREILYQ 757
                         |.|...||::..|. |||||...|:.:.||.:||||:|.   .|.||| |..
Mouse   734 -------------RRALKVARTAEVLSPLGALYYNTGRHKEALEVYREAVSL---QPSQRE-LRL 781

  Fly   758 RIGDVLGRLQQWDEAERHHRAALELQPNQVAAH--LSYGITLARNSSRASEAEMWFKRALKLAPE 820
            .:..||..:.|..|||:.....:..:|..:..:  ||...:...:..:|.||   .::||:|.|:
Mouse   782 ALAQVLAVMGQTKEAEKITSHIVSEEPRCLECYRLLSAIHSKQEHHGKALEA---IEKALQLKPK 843

  Fly   821 QASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVAL 885
            ...|.               |.::..:..:|...:            |||:..::   |..||.|
Mouse   844 DPKVI---------------SELFFTKGNQLREQN------------LLDKAFES---YEAAVTL 878

  Fly   886 RPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGDAITLGNLAKL 933
            .|..|.|..|:|.|.|:.|....|.|.|:.||:|.|...:...|||||
Mouse   879 DPDQAQAWMNMGGIRHIQGSYVSARAYYERALKLVPDSKLLKENLAKL 926

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	50/127 (39%)
		DUF1736	275..343	CDD:285594	27/67 (40%)
		TPR_11	602..667	CDD:290150	29/100 (29%)
		TPR_1	602..634	CDD:278916	14/33 (42%)
		TPR repeat	602..630	CDD:276809	13/29 (45%)
		TPR repeat	635..665	CDD:276809	14/63 (22%)
		TPR_11	636..700	CDD:290150	24/97 (25%)
		TPR_1	636..668	CDD:278916	14/65 (22%)
		TPR repeat	670..694	CDD:276809	9/23 (39%)
		TPR_11	714..784	CDD:290150	26/70 (37%)
		TPR repeat	715..743	CDD:276809	13/28 (46%)
		TPR repeat	748..782	CDD:276809	11/33 (33%)
		TPR_11	755..819	CDD:290150	16/65 (25%)
		TPR repeat	787..816	CDD:276809	6/30 (20%)
		TPR_11	821..887	CDD:290150	10/65 (15%)
		TPR repeat	822..850	CDD:276809	2/27 (7%)
		TPR repeat	855..885	CDD:276809	6/29 (21%)
		TPR_11	<874..921	CDD:290150	18/46 (39%)
		TPR repeat	890..918	CDD:276809	11/27 (41%)
Tmtc1	NP_945318.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	245..285		0/39 (0%)
		DUF1736	351..425	CDD:285594	30/78 (38%)
		TPR_11	542..605	CDD:290150	1/62 (2%)
		TPR 1	543..576		0/32 (0%)
		TPR_2	543..576	CDD:285020	0/32 (0%)
		TPR repeat	543..571	CDD:276809	0/27 (0%)
		TPR repeat	576..603	CDD:276809	1/26 (4%)
		TPR 2	577..607		2/29 (7%)
		TPR	577..607	CDD:197478	2/29 (7%)
		TPR_17	596..628	CDD:290167	12/31 (39%)
		TPR 3	608..641		15/32 (47%)
		TPR repeat	608..636	CDD:276809	13/27 (48%)
		TPR	621..940	CDD:223533	101/356 (28%)
		TPR 4	642..675		5/32 (16%)
		TPR repeat	642..670	CDD:276809	4/27 (15%)
		TPR repeat	675..705	CDD:276809	9/29 (31%)
		TPR 5	676..709		10/32 (31%)
		TPR 6	710..742		12/44 (27%)
		TPR repeat	710..738	CDD:276809	11/40 (28%)
		TPR_7	715..744	CDD:289919	11/41 (27%)
		TPR 7	743..776		15/35 (43%)
		TPR repeat	743..771	CDD:276809	13/27 (48%)
		TPR_14	749..786	CDD:290164	18/40 (45%)
		TPR repeat	776..806	CDD:276809	10/30 (33%)
		TPR 8	811..844		9/35 (26%)
		TPR repeat	812..839	CDD:276809	6/29 (21%)
		TPR repeat	844..878	CDD:276809	9/63 (14%)
		TPR 9	849..882		10/47 (21%)
		TPR 10	883..916		14/32 (44%)
		TPR_1	883..915	CDD:278916	13/31 (42%)
		TPR repeat	883..911	CDD:276809	11/27 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810