DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and Tmtc3

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_477246.2	Gene:	Tmtc3 / 37401	FlyBaseID:	FBgn0020312	Length:	926	Species:	Drosophila melanogaster

Alignment Length:	1046	Identity:	279/1046 - (26%)
Similarity:	404/1046 - (38%)	Gaps:	334/1046 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 MDFTCLFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGS 95
            ::|.|:  |....|.|.|:...|.|:||..||..|.|:...||....|.|||||||:....||.|
  Fly    35 LEFLCI--CVACIVCYYNSTQCGLVFDDISAIRDNKDLRPHTPLINVFLNDFWGTPMRKEQSHKS 97

  Fly    96 WRPLCVLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWA------------- 147
            :|||.||:||.|||: ....|:|:||||.|||.....|..||.|.||....|
  Fly    98 YRPLTVLTFRFNYLL-HALEPFGYHLVNLLLHLSVCLLWRRVCRLLLRQCAASGSNAISAPSSSS 161

  Fly   148 -------VLAAGALFAAHPIHTEAVAGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQ--WL 203
                   ...|..|||.||:|||||.||||||:|.:.:|:|..:|||.:.:  .:||.||:  ||
  Fly   162 VSQLNTCAFVASLLFAVHPVHTEAVTGVVGRAELLSSICFLAAFLSYAKSV--GDSGCPRRTNWL 224

  Fly   204 AL----GATLILAAAGLLCKETAITALLVCALFD---------------VMRGLSGQVDKQR--- 246
            .|    |:.|:   |.:||||..||...:|.:::               |:|....:.::|.
  Fly   225 TLFGCFGSCLL---ASMLCKEQGITIAGICVVYELFVVHQLRPLHLCHFVLRLFDERTEQQSPKL 286

  Fly   247 --------------LRSVCIVLGALFCMAYCRLVIVPGPQTAFSSADNP--IARTPSAWTRLLTF 295
                          .:.:..::|....:...|:.::......|:..|||  .|.||.   |.||:
  Fly   287 ANPSGIRRWSSSTLWKRLSFLVGITLTLLVGRVYVMGSQLPIFTRFDNPASAADTPE---RQLTY 348

  Fly   296 LYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWGSCRQLLSGSKEV 360
            .||...|..|||.|::|..||.|..:|.:....|.||     ..::|..:|.|:.
  Fly   349 GYLIYLNCWLLLCPSLLCCDWTMGTVPLLQGFTDSRN-----ITTLLTFLALGAM---------- 398

  Fly   361 THCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCRDCNNNNSSGYVY 425
                |:.|
  Fly   399 ----VAKT--------------------------------------------------------- 402

  Fly   426 EGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSSSLSGGFQCSSKDY 490
                                                                       |.:::.
  Fly   403 -----------------------------------------------------------CFTRNL 408

  Fly   491 ALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVGFCLLVGYGVSKLMS 555
            ||         :..|||.|.::.|||||||||.|.||||||||:||:||:|:||||.||..:|
  Fly   409 AL---------SRTLIMCLGWMVLPFLPASNLFFPVGFVVAERILYMPSMGYCLLVAYGFEQL-- 462

  Fly   556 CNQRTRNILLLSFS-----LLLAAMSLRTLRRNADWRDEESLYRSAIAINP--PKALGNLGSVLS 613
              ||..::....||     :||...:|:|.:||.|||.|.||:.|.:.:|.  .|...|:|..|.
  Fly   463 --QRRGSLSWQRFSQAALAILLLTHALKTHQRNLDWRTEYSLFMSGVHVNQRNAKLYNNVGHALE 525

  Fly   614 SQGRYEEAKQVLQEAIRFRPNMADVHFNLG----------------------------------- 643
            ::|::|||....|:|:|.:.:....|.|:|
  Fly   526 NEGKFEEALLYFQQAVRIQTDDIGAHINVGRTFNNLKRYAEAEQAYVQAKALFPQAKPGVSYHAR 590

  Fly   644 --------------ILHQNQQVYPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQ 694
                          ::.:||.....|...:::||..|.:...||:|.|...:.|.:..||.|:.:
  Fly   591 IAPNHLNVFINLANLIAKNQTRLEEADHLYRQAISMRSDYVQAYINRGDILMKLNRTAQAQEVYE 655

  Fly   695 AGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALAIYREALSSLPGLPQ---QREILY 756
                       ....:|...:..|..||.:::||||.|:|...:.:|:...|...|   ...||.
  Fly   656 -----------QALLYDNENADIYYNLGVVFLEQGKSQQAQVYFNKAIELYPEHEQALLNSAILL 709

  Fly   757 QRIGDVLGRLQQWDEAERHHRA----ALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKL 817
            |.:|.        :||.|..|:    .||........:.:.|: ||.:.|...|||.:||||:.|
  Fly   710 QELGG--------EEARRVSRSRLYKVLENDDQNEKVYFNLGM-LAMDESSFDEAEQFFKRAIHL 765

  Fly   818 APEQASVYHHYA-------------EFLSLQSRHHESAIYHRRAAELAPNDYTLVVAAATAMRLL 869
            ..:..|...:.|             .||:...|||.|   |.:...|..:.|      ...|:.|
  Fly   766 KADFRSALFNLALLLADTKRPLDAVPFLNQLIRHHPS---HVKGLILLGDIY------INHMKDL 821

  Fly   870 DRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGD-------AITL 927
            |   :||..||..:...|.:.....||..:.....|...|||..:.|.||.|.:       .|.|
  Fly   822 D---EAEKCYRSILHYDPHNTQGLHNLCVVFVERKRLAKAAACLQYAQRLAPAEDYIGRHLQIVL 883

  Fly   928 GNLAKL 933
            ..|.|:
  Fly   884 ARLQKI 889

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	56/145 (39%)
		DUF1736	275..343	CDD:285594	25/69 (36%)
		TPR_11	602..667	CDD:290150	19/113 (17%)
		TPR_1	602..634	CDD:278916	11/31 (35%)
		TPR repeat	602..630	CDD:276809	10/27 (37%)
		TPR repeat	635..665	CDD:276809	8/78 (10%)
		TPR_11	636..700	CDD:290150	17/112 (15%)
		TPR_1	636..668	CDD:278916	9/80 (11%)
		TPR repeat	670..694	CDD:276809	8/23 (35%)
		TPR_11	714..784	CDD:290150	22/76 (29%)
		TPR repeat	715..743	CDD:276809	10/27 (37%)
		TPR repeat	748..782	CDD:276809	10/40 (25%)
		TPR_11	755..819	CDD:290150	21/67 (31%)
		TPR repeat	787..816	CDD:276809	11/28 (39%)
		TPR_11	821..887	CDD:290150	18/78 (23%)
		TPR repeat	822..850	CDD:276809	9/40 (23%)
		TPR repeat	855..885	CDD:276809	8/29 (28%)
		TPR_11	<874..921	CDD:290150	14/46 (30%)
		TPR repeat	890..918	CDD:276809	7/27 (26%)
Tmtc3	NP_477246.2	DUF1736	323..396	CDD:369859	27/80 (34%)
		PEP_TPR_lipo	<513..871	CDD:274350	91/389 (23%)
		TPR repeat	514..542	CDD:276809	10/27 (37%)
		TPR repeat	547..591	CDD:276809	3/43 (7%)
		TPR repeat	598..625	CDD:276809	4/26 (15%)
		TPR repeat	630..660	CDD:276809	8/40 (20%)
		TPR repeat	665..693	CDD:276809	10/27 (37%)
		TPR repeat	737..764	CDD:276809	11/27 (41%)
		TPR repeat	803..834	CDD:276809	10/39 (26%)
		TPR repeat	839..867	CDD:276809	7/27 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45467045
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.750