DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4341 and IFIT2

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001538.4	Gene:	IFIT2 / 3433	HGNCID:	5409	Length:	472	Species:	Homo sapiens

Alignment Length:	296	Identity:	55/296 - (18%)
Similarity:	114/296 - (38%)	Gaps:	76/296 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   594 RSAIAINPP----KALGNLG-SVLSSQGRYE-EAKQVLQEAIRFRPNMADVHFNLGILHQNQQVY 652
            |.||.:||.    |.|..|. ..:..:|..| |.:::::||:...|.:.||..:....::.:...
Human   199 RQAIRLNPDNQYLKVLLALKLHKMREEGEEEGEGEKLVEEALEKAPGVTDVLRSAAKFYRRKDEP 263

  Fly   653 PAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSA 717
            ..|:|..::|:::.||.|..:..:|..:     |.:..:::....|
Human   264 DKAIELLKKALEYIPNNAYLHCQIGCCY-----RAKVFQVMNLREN------------------- 304

  Fly   718 YLQLGALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIGDVLGRL----QQWDEAERHHRA 778
                 .:|   || ::.|.:...|::.|....:..:.|: |:..:|..|    .|:::||.:.:.
Human   305 -----GMY---GK-RKLLELIGHAVAHLKKADEANDNLF-RVCSILASLHALADQYEDAEYYFQK 359

  Fly   779 ALELQPNQVA---AHLSYGITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHE 840
            ....:...||   .||.||           ..:::     ::..|..:: ||:.|.:.:..:..|
Human   360 EFSKELTPVAKQLLHLRYG-----------NFQLY-----QMKCEDKAI-HHFIEGVKINQKSRE 407

  Fly   841 SAIYHRRAAELAPNDYTLVVAAATAMRLLDRKVDAE 876
            ......:..::|            .|||.....|:|
Human   408 KEKMKDKLQKIA------------KMRLSKNGADSE 431

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453
		DUF1736	275..343	CDD:285594
		TPR_11	602..667	CDD:290150	14/70 (20%)
		TPR_1	602..634	CDD:278916	8/37 (22%)
		TPR repeat	602..630	CDD:276809	8/33 (24%)
		TPR repeat	635..665	CDD:276809	5/29 (17%)
		TPR_11	636..700	CDD:290150	11/63 (17%)
		TPR_1	636..668	CDD:278916	5/31 (16%)
		TPR repeat	670..694	CDD:276809	3/23 (13%)
		TPR_11	714..784	CDD:290150	13/73 (18%)
		TPR repeat	715..743	CDD:276809	5/27 (19%)
		TPR repeat	748..782	CDD:276809	7/37 (19%)
		TPR_11	755..819	CDD:290150	13/70 (19%)
		TPR repeat	787..816	CDD:276809	6/31 (19%)
		TPR_11	821..887	CDD:290150	10/56 (18%)
		TPR repeat	822..850	CDD:276809	4/27 (15%)
		TPR repeat	855..885	CDD:276809	5/22 (23%)
		TPR_11	<874..921	CDD:290150	2/3 (67%)
		TPR repeat	890..918	CDD:276809
IFIT2	NP_001538.4	TPR_12	51..112	CDD:290160
		TPR 1. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	51..89
		TPR 2. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	90..135
		TPR 3. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	136..171
		TPR 4. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	172..208		5/8 (63%)
		TPR repeat	208..236	CDD:276809	6/27 (22%)
		TPR 5. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	247..280		6/32 (19%)
		TPR repeat	248..275	CDD:276809	5/26 (19%)
		TPR repeat	280..329	CDD:276809	10/81 (12%)
		TPR 6. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	281..335		11/87 (13%)
		TPR repeat	334..359	CDD:276809	6/25 (24%)
		TPR 7. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	336..366		5/29 (17%)
		TPR 8. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	367..405		10/54 (19%)
		TPR 9. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00339, ECO:0000269\|PubMed:22825553	406..448		7/38 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	446..472
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810