DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc2 and TTC6

DIOPT Version :10

Sequence 1:NP_608558.1 Gene:Tmtc2 / 33276 FlyBaseID:FBgn0028481 Length:938 Species:Drosophila melanogaster
Sequence 2:XP_047287288.1 Gene:TTC6 / 319089 HGNCID:19739 Length:1894 Species:Homo sapiens


Alignment Length:849 Identity:157/849 - (18%)
Similarity:273/849 - (32%) Gaps:232/849 - (27%)


- Green bases have known domain annotations that are detailed below.


  Fly   183 TY--LSYLRHMRWRESG---------DPRQWLAL---GATLILAAAGLLCKETAITAL------- 226
            ||  ::|::...::|:.         ||..||||   |.....:......::.:::||       
Human  1090 TYRGIAYVKWKFYKEATQDFSAAIHLDPNNWLALYYRGCLFRKSNPFRALQDYSVSALINDGYEN 1154

  Fly   227 LVCALFDVMRGLSGQVDKQRLRSVCIVLGALFCMAYCRLVIVPGPQTAFSSADNPIARTPSAWTR 291
            |.|.|.               |.:......|:.:|.|..                  .|..:..|
Human  1155 LGCFLH---------------RGIVYAHLKLWLLAICDF------------------ETVISLER 1186

  Fly   292 LLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWGSCRQLLSG 356
            .:|..|:.:..:.||...|.....|......|:..|         |..|.|              
Human  1187 TITLAYVNIGLIHLLHLDNYTEAIWQFSEAIRIDPL---------CIQSYL-------------- 1228

  Fly   357 SKEVTHCGVSSTFPQYHIQKVASRKSRS---------------------KRKRLANNTKYQAFE- 399
                  |...:.|..:.::|..:..||:                     |...||..|.||..| 
Human  1229 ------CRAETYFKLHKLKKAVNELSRAIHLQPDGIQLYIRRGQYLLMMKYYDLAKFTIYQIAEM 1287

  Fly   400 ---AAYHQQQQEALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSS---CSNS 458
               .:.....|:||....|.|::.:..|.:|.|...........|.....:..|:..:   ...:
Human  1288 DKGLSELSPMQQALIYSFCENHDKAIEVLDGISWNRAEMTMCALLAKVQMKAKRTKEAVEVLKKA 1352

  Fly   459 TNSSSSSSSSSSSSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLL 523
            .::.|.|.....:::.|:..|.....|    |..||.           :.::|.:......:|..
Human  1353 LDAISHSDKGPDATAISADCLYNLGLC----YMEEGN-----------LQMAFDSFTKAVKANPD 1402

  Fly   524 FYVGFVVAERLLYLPSVGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRD 588
            |...|.  :|       |.|.:..:..|.::..|:                              
Human  1403 FAESFY--QR-------GLCKVKLHKDSSILDFNR------------------------------ 1428

  Fly   589 EESLYRSAIAINP----PKALGNLGSVLSS------QGRYEEAKQVLQEAIRFRPNMADVHFNLG 643
                   ||.:||    ....|.||:.||.      :|||.:|.....:||:..|.....:...|
Human  1429 -------AITLNPKHYQEMHTGGLGAYLSRVAFYGLKGRYSKAILNCNKAIKIYPESVRAYLYRG 1486

  Fly   644 ILHQNQQVYPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRT 708
            :|....:.|..|:.....||....|...|:.|..:.:..:.:.|.|:        .|...|....
Human  1487 VLKYYNKTYKLAITDLTTAISMDKNSYTAFYNRALCYTKIRELQMAL--------TDYGIVLLLD 1543

  Fly   709 AHDQARSSAYLQLGALYVEQGKLQRALAIYREA--LSSLPG-LPQQREILYQRIGD--------- 761
            |.:..:.:.:|..|.:|||.|:...||..:::|  :|...| |.....:.:.||.:         
Human  1544 ATETVKLNTFLNRGLIYVELGQYGFALEDFKQAALISRTNGSLCHATAMCHHRINEFEEAVNFFT 1608

  Fly   762 ------------VLGRLQQWDE---------AERHHRAALELQPNQVAAHLSYGITLARNSSRAS 805
                        .:||...:.|         |::....||.:.|..:.|.:|:|..|   .::..
Human  1609 WALKINPCFLDAYVGRGNSYMEYGHDEATKQAQKDFLKALHINPAYIKARISFGYNL---QAQGK 1670

  Fly   806 EAEMW--FKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYTLVVAAATAMRL 868
            ..:.|  |..|:...|:....|...| .:.||..::.:|:....||.........:.........
Human  1671 FQKAWNHFTIAIDTDPKNYLAYEGRA-VVCLQMGNNFAAMQDINAAMKISTTAEFLTNRGVIHEF 1734

  Fly   869 LDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGDAITLGNLAKL 933
            :..|.:|...|:.|:.|.|..:.|:.|.|.|.....:.:.|:..:..||:..|.:...|.|.|  
Human  1735 MGHKQNAMKDYQDAITLNPKYSLAYFNAGNIYFHHRQFSQASDYFSKALKFDPENEYVLMNRA-- 1797

  Fly   934 GVTN 937
             :||
Human  1798 -ITN 1800

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc2NP_608558.1 TMTC_DUF1736 270..343 CDD:462468 12/72 (17%)
TPR 597..852 CDD:440225 65/299 (22%)
TPR repeat 602..630 CDD:276809 10/33 (30%)
TPR repeat 635..665 CDD:276809 6/29 (21%)
TPR repeat 670..694 CDD:276809 4/23 (17%)
TPR repeat 715..743 CDD:276809 9/29 (31%)
TPR repeat 748..782 CDD:276809 9/63 (14%)
TPR 780..>933 CDD:440225 34/154 (22%)
TPR repeat 787..816 CDD:276809 7/30 (23%)
TPR repeat 822..850 CDD:276809 6/27 (22%)
TPR repeat 855..885 CDD:276809 4/29 (14%)
TPR repeat 890..918 CDD:276809 6/27 (22%)
TTC6XP_047287288.1 TPR repeat 917..945 CDD:276809
PEP_TPR_lipo 924..1816 CDD:274350 157/849 (18%)
TPR repeat 950..980 CDD:276809
TPR repeat 986..1013 CDD:276809
TPR repeat 1018..1047 CDD:276809
TPR repeat 1053..1080 CDD:276809
TPR repeat 1085..1115 CDD:276809 4/24 (17%)
TPR repeat 1157..1183 CDD:276809 7/58 (12%)
TPR repeat 1191..1218 CDD:276809 5/26 (19%)
TPR repeat 1223..1253 CDD:276809 8/49 (16%)
TPR repeat 1292..1317 CDD:276809 6/24 (25%)
TPR repeat 1331..1354 CDD:276809 2/22 (9%)
TPR repeat 1370..1398 CDD:276809 6/42 (14%)
TPR repeat 1403..1432 CDD:276809 9/74 (12%)
TPR repeat 1447..1473 CDD:276809 7/25 (28%)
TPR repeat 1478..1508 CDD:276809 6/29 (21%)
TPR repeat 1513..1536 CDD:276809 4/30 (13%)
TPR repeat 1552..1578 CDD:276809 9/25 (36%)
TPR repeat 1583..1613 CDD:276809 4/29 (14%)
TPR repeat 1618..1648 CDD:276809 4/29 (14%)
TPR repeat 1655..1683 CDD:276809 7/30 (23%)
TPR repeat 1688..1718 CDD:276809 7/30 (23%)
TPR 1722..>1891 CDD:440225 19/82 (23%)
TPR repeat 1722..1750 CDD:276809 4/27 (15%)
TPR repeat 1758..1784 CDD:276809 6/25 (24%)
TPR repeat 1789..1819 CDD:276809 5/15 (33%)
TPR repeat 1824..1852 CDD:276809
TPR repeat 1858..1886 CDD:276809
Blue background indicates that the domain is not in the aligned region.

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