DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and Tmtc3

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_017450330.2	Gene:	Tmtc3 / 314785	RGDID:	1306351	Length:	1022	Species:	Rattus norvegicus

Alignment Length:	943	Identity:	251/943 - (26%)
Similarity:	382/943 - (40%)	Gaps:	277/943 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 YLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLCVLSFRLNYLI 110
            |.|:|..|||:||..|||.|.|:...||.:..|.|||||||:::..||.|:|||.||:||||||:
  Rat   127 YWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTFRLNYLL 191

  Fly   111 GGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAVAGVVGRADLA 175
             ....|..:||:|.:.|.|.:.:.::|.|..|....:|:|| .|||.||||||||.||||||:|.
  Rat   192 -SELKPMSYHLLNTVFHAVVSVIFLKVCRLFLDKRGSVIAA-LLFAVHPIHTEAVTGVVGRAELL 254

  Fly   176 ACVCYLLTYLSYLRHMRWRESGDPRQ---WLALGATLILAAAGLLCKETAITALLVCALFDV--- 234
            :.|.:|..:|||.:      |..|..   |..:..|::|.|...||||..||.:.:|.:::|
  Rat   255 SSVFFLAAFLSYTK------SKGPDNSIVWTPIALTVLLVAVATLCKEQGITVVGICCVYEVFVA 313

  Fly   235 -------MRGLSGQVDK----------QRLRSVCIVLGALFCMAYCRLVIVPGPQTAFSSADNPI 282
                   :..::||..:          |.|..:.:::.:...:...|:.::......|:..|||.
  Rat   314 QGYTLPLLCAVAGQFLRGKGSIPFSMLQTLIKLIVLMFSTLLLVVIRVQVIQSQLPVFTRFDNPA 378

  Fly   283 ARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAW 347
            |.:|:. ||.|||.||...|..|||.|:.|..||.|..:|.:.|..|.||..:..|:..|..:..
  Rat   379 AVSPTP-TRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESFLDVRNLATFAFFCFLGALGI 442

  Fly   348 GSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPC 412
            .|.|
  Rat   443 FSLR------------------------------------------------------------- 446

  Fly   413 RDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSS 477
                        |.|.
  Rat   447 ------------YPGD------------------------------------------------- 450

  Fly   478 SLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVGF 542
                    |||               .::|:||.:||||:|||||.|.||||||||:||:||:||
  Rat   451 --------SSK---------------TVLMALSLMALPFIPASNLFFPVGFVVAERVLYVPSMGF 492

  Fly   543 CLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINP--PKAL 605
            |:||.:|..|: |.....:.:..:..|:::...:|:||.||.||..|.:|:.||:.:|.  .|..
  Rat   493 CILVAHGWQKI-SNKSVLKKLSWVCLSMVILTHALKTLHRNWDWESEYTLFMSALKVNKNNAKLW 556

  Fly   606 GNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQN--------------QQVYPAAV 656
            .|:|..|.::..:|:|.:...:|...:|:....|.|:|..::|              :.:.|..:
  Rat   557 NNVGHALENEKNFEKALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTKEAEESYMLAKSLMPQII 621

  Fly   657 ECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQL 721
            ...:.|.:..||....|:||.....|...|      |:....|...|:..|....|    ||:..
  Rat   622 PGKKYAARIAPNHLNVYINLANLIRANESR------LEEADQLYRQAISMRPDFKQ----AYISR 676

  Fly   722 GALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALEL---- 782
            |.|.::..|..:|...|.:||.    |.:....|:..:..|...|::.|||.::...||||
  Rat   677 GELLLKMNKPLKAKEAYLKALE----LDRNNADLWYNLAIVYIELKEPDEALKNFNRALELNSRH 737

  Fly   783 ---------------------------------QPNQVAAHLSYGITLARNSSRASEAEMWFKRA 814
                                             :|.....:.:.|: ||.:..:.||||.|.|||
  Rat   738 KLALFNSAILMQESGEVKLRPEARKRLLNYINEEPQDANGYFNLGM-LAMDDKKDSEAETWMKRA 801

  Fly   815 LKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAP-----------NDYT--LVVAAATAM 866
            :||.|:..|...:.|            .:|.:.|.||..           .|:|  |::....
  Rat   802 IKLQPDFRSALFNLA------------LLYSQTAKELKALPILEELLRYYPDHTKGLILKGDI-- 852

  Fly   867 RLLDRKVD---AEMWYRKAVALRPGDAHAHTNL 896
             |:::|.|   |:..:.|.:.:.|.:.....||
  Rat   853 -LMNQKKDIAGAKKCFEKILEMDPSNVQGKHNL 884

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	48/122 (39%)
		DUF1736	275..343	CDD:285594	28/67 (42%)
		TPR_11	602..667	CDD:290150	14/78 (18%)
		TPR_1	602..634	CDD:278916	7/31 (23%)
		TPR repeat	602..630	CDD:276809	7/27 (26%)
		TPR repeat	635..665	CDD:276809	6/43 (14%)
		TPR_11	636..700	CDD:290150	14/77 (18%)
		TPR_1	636..668	CDD:278916	6/45 (13%)
		TPR repeat	670..694	CDD:276809	5/23 (22%)
		TPR_11	714..784	CDD:290150	20/106 (19%)
		TPR repeat	715..743	CDD:276809	8/27 (30%)
		TPR repeat	748..782	CDD:276809	9/33 (27%)
		TPR_11	755..819	CDD:290150	24/100 (24%)
		TPR repeat	787..816	CDD:276809	11/28 (39%)
		TPR_11	821..887	CDD:290150	14/81 (17%)
		TPR repeat	822..850	CDD:276809	4/27 (15%)
		TPR repeat	855..885	CDD:276809	8/34 (24%)
		TPR_11	<874..921	CDD:290150	6/26 (23%)
		TPR repeat	890..918	CDD:276809	2/7 (29%)
Tmtc3	XP_017450330.2	DUF1736	366..438	CDD:400627	28/72 (39%)
		PEP_TPR_lipo	<542..909	CDD:274350	81/373 (22%)
		TPR repeat	553..581	CDD:276809	7/27 (26%)
		TPR repeat	586..630	CDD:276809	6/43 (14%)
		TPR repeat	637..664	CDD:276809	8/32 (25%)
		TPR repeat	669..699	CDD:276809	10/37 (27%)
		TPR repeat	704..732	CDD:276809	7/27 (26%)
		TPR repeat	775..803	CDD:276809	11/28 (39%)
		TPR repeat	808..838	CDD:276809	6/41 (15%)
		TPR repeat	843..872	CDD:276809	7/31 (23%)
		TPR repeat	878..901	CDD:276809	2/7 (29%)
		ParB_N_Srx	901..>943	CDD:421688
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820