Protein Alignment Tmtc2 and Tomm34

DIOPT Version :10

• Sequence 1: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_001037709.1
• Gene: Tomm34 / 311621
• RGDID: 1309029
• Length: 309
• Species: Rattus norvegicus
• Alignment Length: 268
• Identity: 59/268 - (22%)
• Similarity: 102/268 - (38%)
• Gaps: 56/268 - (20%)

  Fly   557 NQRTRNILLLSFSLLL-AAMSLRTLRRNADWRDEESLY--------------------RSAIAIN 600
            ||..||......|.|. .|:.|...|.:||..:|..||                    .||:|:.
  Rat    17 NQNFRNGQYGEASALYERALRLLQARGSADPEEESVLYSNRAACYLKDGNCTDCIKDCTSALALV 81

  Fly   601 PPKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPA--AVECFQRAI 663
            |    .::..:|.....||..::.         ::|.|.:.. :|..:..|..|  .:....||:
  Rat    82 P----FSIKPLLRRASAYEALEKY---------SLAYVDYKT-VLQIDNSVASALEGINRITRAL 132

  Fly   664 --KFRPNLAVAYLNLGISFIALGKRQQAI------EILQAGSNLDGAAVRDR--TAHDQARSSAY 718
              ...|...:....:.:..::..||..::      |..::.|. :..|.::|  :|.|..|:...
  Rat   133 MDSLGPEWRLKLPPIPVVPVSAQKRWSSLPSENHKETAKSKSK-ETTATKNRVPSAGDVERARVL 196

  Fly   719 LQLGALYVEQGKLQRALAIYREAL--SSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALE 781
            .:.|...|::|..::|:..|.|:|  |||.........|...:      |:|:.|||:....||:
  Rat   197 KEEGNELVKKGNHKKAIEKYSESLLFSSLESATYSNRALCHLV------LKQYKEAEKDCTEALK 255

  Fly   782 LQPNQVAA 789
            |....|.|
  Rat   256 LDGKNVKA 263

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468
		TPR	597..852	CDD:440225	43/207 (21%)
		TPR repeat	602..630	CDD:276809	3/27 (11%)
		TPR repeat	635..665	CDD:276809	7/33 (21%)
		TPR repeat	670..694	CDD:276809	3/29 (10%)
		TPR repeat	715..743	CDD:276809	7/29 (24%)
		TPR repeat	748..782	CDD:276809	8/33 (24%)
		TPR	780..>933	CDD:440225	4/10 (40%)
		TPR repeat	787..816	CDD:276809	2/3 (67%)
		TPR repeat	822..850	CDD:276809
		TPR repeat	855..885	CDD:276809
		TPR repeat	890..918	CDD:276809
Tomm34	NP_001037709.1	TPR 1	9..42		8/24 (33%)
		TPR repeat	9..37	CDD:276809	7/19 (37%)
		3a0801s09	<11..>294	CDD:273380	59/268 (22%)
		TPR repeat	50..80	CDD:276809	5/29 (17%)
		TPR 2	51..84		6/36 (17%)
		TPR repeat	85..113	CDD:276809	5/37 (14%)
		TPR 3	86..118		6/41 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	158..187		4/29 (14%)
		TPR 4	193..226		9/32 (28%)
		TPR repeat	193..221	CDD:276809	6/27 (22%)
		TPR repeat	226..256	CDD:276809	8/35 (23%)
		TPR 5	227..260		9/38 (24%)
		TPR repeat	261..289	CDD:276809	2/3 (67%)
		TPR 6	262..294		1/2 (50%)