Protein Alignment Tmtc2 and Tmtc2

DIOPT Version :10

• Sequence 1: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_001164648.2
• Gene: Tmtc2 / 299762
• RGDID: 1309848
• Length: 836
• Species: Rattus norvegicus
• Alignment Length: 920
• Identity: 346/920 - (37%)
• Similarity: 481/920 - (52%)
• Gaps: 124/920 - (13%)

  Fly    36 LFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLC 100
            |...:|...||||||.|.|.|||.|||..|.|:...|||...|.||||||.||.||||.|:||||
  Rat     5 LVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLC 69

  Fly   101 VLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAV 165
            .||||||:.| ||..||.:||||.|||...|.|..|.::.||...:....||.:||:||||||||
  Rat    70 TLSFRLNHAI-GGLNPWSYHLVNVLLHAAVTGLFTRFSKALLGDGYWTFMAGLMFASHPIHTEAV 133

  Fly   166 AGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQWLALGATLILAAAGLLCKETAITALLVCA 230
            ||:|||||:.|.:.:||:.|.|.:|...| ....|.|.....|.:.|...:|.||..:|.|.|.|
  Rat   134 AGIVGRADVGASLFFLLSLLCYTKHCSTR-GYSARTWGWFLGTGLCAGCSMLWKEQGVTVLAVSA 197

  Fly   231 LFDV-------MRGLSGQVDKQRLRSVCI-----------VLGALFCMAYCRLVIVPGPQTAFSS 277
            ::||       ||.:...:.|::..|:.:           :|||       ||..:.....:||:
  Rat   198 VYDVFVFHRLKMRQILPTIYKRKNLSLFLSISLLTFWGTSLLGA-------RLYWMGNKPPSFSN 255

  Fly   278 ADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVL 342
            :|||.|.:.|...|.|||.|||..||.|||.|:.|||||.|||:|.:.::.|.||..:..|||.|
  Rat   256 SDNPAADSDSLLARTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYSGL 320

  Fly   343 VGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQ 407
            :.:|               :||:.|          .|.:.....|.:.|
  Rat   321 LLLA---------------YCGLKS----------PSLEGECNGKAVTN---------------- 344

  Fly   408 EALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSS 472
                    ...|::|:                              ||.:.....:|....|.:|
  Rat   345 --------GKQNANGH------------------------------SCYSDVEYRNSEIKPSFAS 371

  Fly   473 SSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYL 537
            ...:...|    |.|:...|    |:..:  ::|:|||.|.:||:||:||.||||||:|||:||:
  Rat   372 KVENGIKS----CVSQRPQL----PSTEN--IVILSLSLLIIPFIPATNLFFYVGFVIAERVLYI 426

  Fly   538 PSVGFCLLVGYGVSKLMSCNQR--TRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAIN 600
            ||:|||||:..|...|....|:  .::::..:.:.|:....|:|..||.||::||.||||.|.:|
  Rat   427 PSMGFCLLITVGARALYVKVQKRFLKSLVFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVN 491

  Fly   601 PPKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKF 665
            |.||.||||:||.||.:..||:...:.|:.:|.||||:.:|||:|.|....:..|:..::.|:..
  Rat   492 PAKAWGNLGNVLKSQSKISEAEIAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAVGS 556

  Fly   666 RPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGK 730
            ||.||.||||.||..:..||.::|.......|.:....::|..||..:.:|....||.||.|||:
  Rat   557 RPTLASAYLNTGIILMNQGKTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGR 621

  Fly   731 LQRALAIYREALSSLPG--LPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSY 793
            .:.||::||||:..:|.  .||.   ||..:|:...||.:..|||..:..:|..:.:.:.|||:|
  Rat   622 YEEALSVYREAIQKMPRQFAPQS---LYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTY 683

  Fly   794 GITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYTL 858
            |..||. :.|.||||.:|.:|::|.|.:.:.|.||.:||..:||..|:|...::||||...::.:
  Rat   684 GKLLAL-TGRKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELDSTEFDV 747

  Fly   859 VVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGD 923
            |..||..:|.......||.:|..|..|||....|..||||||||.||...|.|:|..||:|:|.|
  Rat   748 VFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDD 812

  Fly   924 AITLGNLAKL 933
            .||..||.||
  Rat   813 VITQSNLRKL 822

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468	35/72 (49%)
		TPR	597..852	CDD:440225	99/256 (39%)
		TPR repeat	602..630	CDD:276809	13/27 (48%)
		TPR repeat	635..665	CDD:276809	10/29 (34%)
		TPR repeat	670..694	CDD:276809	10/23 (43%)
		TPR repeat	715..743	CDD:276809	14/27 (52%)
		TPR repeat	748..782	CDD:276809	11/33 (33%)
		TPR	780..>933	CDD:440225	64/152 (42%)
		TPR repeat	787..816	CDD:276809	14/28 (50%)
		TPR repeat	822..850	CDD:276809	10/27 (37%)
		TPR repeat	855..885	CDD:276809	8/29 (28%)
		TPR repeat	890..918	CDD:276809	15/27 (56%)
Tmtc2	NP_001164648.2	ArnT	<78..>198	CDD:441412	52/119 (44%)
		TMTC_DUF1736	247..321	CDD:462468	35/73 (48%)
		TadD	439..558	CDD:444034	45/120 (38%)
		TPR repeat	493..521	CDD:276809	19/27 (70%)
		LapB	511..807	CDD:442196	113/299 (38%)
		TPR repeat	527..555	CDD:276809	6/29 (21%)
		TPR repeat	560..590	CDD:276809	17/29 (59%)
		TPR repeat	595..634	CDD:276809	13/38 (34%)
		TPR repeat	642..671	CDD:276809	9/28 (32%)
		TPR repeat	679..705	CDD:276809	10/25 (40%)
		TPR repeat	710..774	CDD:276809	21/65 (32%)
		TPR repeat	779..807	CDD:276809	10/27 (37%)