DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and Tmtc2

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_001164648.2	Gene:	Tmtc2 / 299762	RGDID:	1309848	Length:	836	Species:	Rattus norvegicus

Alignment Length:	920	Identity:	346/920 - (37%)
Similarity:	481/920 - (52%)	Gaps:	124/920 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLC 100
            |...:|...||||||.|.|.|||.|||..|.|:...|||...|.||||||.||.||||.|:||||
  Rat     5 LVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLC 69

  Fly   101 VLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAV 165
            .||||||:.| ||..||.:||||.|||...|.|..|.::.||...:....||.:||:||||||||
  Rat    70 TLSFRLNHAI-GGLNPWSYHLVNVLLHAAVTGLFTRFSKALLGDGYWTFMAGLMFASHPIHTEAV 133

  Fly   166 AGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQWLALGATLILAAAGLLCKETAITALLVCA 230
            ||:|||||:.|.:.:||:.|.|.:|...| ....|.|.....|.:.|...:|.||..:|.|.|.|
  Rat   134 AGIVGRADVGASLFFLLSLLCYTKHCSTR-GYSARTWGWFLGTGLCAGCSMLWKEQGVTVLAVSA 197

  Fly   231 LFDV-------MRGLSGQVDKQRLRSVCI-----------VLGALFCMAYCRLVIVPGPQTAFSS 277
            ::||       ||.:...:.|::..|:.:           :|||       ||..:.....:||:
  Rat   198 VYDVFVFHRLKMRQILPTIYKRKNLSLFLSISLLTFWGTSLLGA-------RLYWMGNKPPSFSN 255

  Fly   278 ADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVL 342
            :|||.|.:.|...|.|||.|||..||.|||.|:.|||||.|||:|.:.::.|.||..:..|||.|
  Rat   256 SDNPAADSDSLLARTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYSGL 320

  Fly   343 VGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQ 407
            :.:|               :||:.|          .|.:.....|.:.|
  Rat   321 LLLA---------------YCGLKS----------PSLEGECNGKAVTN---------------- 344

  Fly   408 EALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSS 472
                    ...|::|:                              ||.:.....:|....|.:|
  Rat   345 --------GKQNANGH------------------------------SCYSDVEYRNSEIKPSFAS 371

  Fly   473 SSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYL 537
            ...:...|    |.|:...|    |:..:  ::|:|||.|.:||:||:||.||||||:|||:||:
  Rat   372 KVENGIKS----CVSQRPQL----PSTEN--IVILSLSLLIIPFIPATNLFFYVGFVIAERVLYI 426

  Fly   538 PSVGFCLLVGYGVSKLMSCNQR--TRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAIN 600
            ||:|||||:..|...|....|:  .::::..:.:.|:....|:|..||.||::||.||||.|.:|
  Rat   427 PSMGFCLLITVGARALYVKVQKRFLKSLVFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKVN 491

  Fly   601 PPKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKF 665
            |.||.||||:||.||.:..||:...:.|:.:|.||||:.:|||:|.|....:..|:..::.|:..
  Rat   492 PAKAWGNLGNVLKSQSKISEAEIAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAVGS 556

  Fly   666 RPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGK 730
            ||.||.||||.||..:..||.::|.......|.:....::|..||..:.:|....||.||.|||:
  Rat   557 RPTLASAYLNTGIILMNQGKTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQGR 621

  Fly   731 LQRALAIYREALSSLPG--LPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSY 793
            .:.||::||||:..:|.  .||.   ||..:|:...||.:..|||..:..:|..:.:.:.|||:|
  Rat   622 YEEALSVYREAIQKMPRQFAPQS---LYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLTY 683

  Fly   794 GITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYTL 858
            |..||. :.|.||||.:|.:|::|.|.:.:.|.||.:||..:||..|:|...::||||...::.:
  Rat   684 GKLLAL-TGRKSEAEKFFLKAIELDPTKGNCYMHYGQFLLEESRLTEAAEMAKKAAELDSTEFDV 747

  Fly   859 VVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPGD 923
            |..||..:|.......||.:|..|..|||....|..||||||||.||...|.|:|..||:|:|.|
  Rat   748 VFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPDD 812

  Fly   924 AITLGNLAKL 933
            .||..||.||
  Rat   813 VITQSNLRKL 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	53/119 (45%)
		DUF1736	275..343	CDD:285594	35/67 (52%)
		TPR_11	602..667	CDD:290150	25/64 (39%)
		TPR_1	602..634	CDD:278916	14/31 (45%)
		TPR repeat	602..630	CDD:276809	13/27 (48%)
		TPR repeat	635..665	CDD:276809	10/29 (34%)
		TPR_11	636..700	CDD:290150	23/63 (37%)
		TPR_1	636..668	CDD:278916	10/31 (32%)
		TPR repeat	670..694	CDD:276809	10/23 (43%)
		TPR_11	714..784	CDD:290150	26/71 (37%)
		TPR repeat	715..743	CDD:276809	14/27 (52%)
		TPR repeat	748..782	CDD:276809	11/33 (33%)
		TPR_11	755..819	CDD:290150	24/63 (38%)
		TPR repeat	787..816	CDD:276809	14/28 (50%)
		TPR_11	821..887	CDD:290150	22/65 (34%)
		TPR repeat	822..850	CDD:276809	10/27 (37%)
		TPR repeat	855..885	CDD:276809	8/29 (28%)
		TPR_11	<874..921	CDD:290150	24/46 (52%)
		TPR repeat	890..918	CDD:276809	15/27 (56%)
Tmtc2	NP_001164648.2	DUF1736	247..321	CDD:285594	35/73 (48%)
		TPR_11	493..554	CDD:290150	24/60 (40%)
		TPR repeat	493..521	CDD:276809	13/27 (48%)
		TPR repeat	527..555	CDD:276809	9/27 (33%)
		TPR_12	557..634	CDD:290160	31/76 (41%)
		TPR repeat	560..590	CDD:276809	12/29 (41%)
		TPR repeat	595..634	CDD:276809	17/38 (45%)
		TPR_12	607..671	CDD:290160	25/66 (38%)
		TPR_2	609..638	CDD:285020	13/28 (46%)
		TPR repeat	642..671	CDD:276809	10/31 (32%)
		TPR repeat	679..705	CDD:276809	14/26 (54%)
		TPR repeat	710..774	CDD:276809	21/63 (33%)
		TPR_19	755..822	CDD:291240	31/66 (47%)
		TPR_1	779..812	CDD:278916	18/32 (56%)
		TPR repeat	779..807	CDD:276809	15/27 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	191	1.000	Domainoid score	I3144
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25521
Inparanoid	1	1.050	566	1.000	Inparanoid score	I1031
OMA	1	1.010	-	-		QHG52430
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0004694
OrthoInspector	1	1.000	-	-		otm46229
orthoMCL	1	0.900	-	-		OOG6_106232
Panther	1	1.100	-	-	LDO	PTHR44216
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3302
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	15	14.840