DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and Tmtc4

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	XP_006252585.1	Gene:	Tmtc4 / 290501	RGDID:	1560183	Length:	773	Species:	Rattus norvegicus

Alignment Length:	925	Identity:	246/925 - (26%)
Similarity:	374/925 - (40%)	Gaps:	253/925 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPSLEPWLWGDSCSWLGMLAMLRLRLHKSNMDFTCLFCCSLAFVLYLNTLGAGFVYDDRRAILAN 65
            :||:.|..|.                 |..:.|..|.|       :..:....||:||..||:.|
  Rat    44 IPSVLPPFWA-----------------KLVVGFVSLLC-------FARSYDGDFVFDDSEAIVNN 84

  Fly    66 ADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLCVLSFRLNYLIGGGFAPWGFHLVNNLLHCVA 130
            .|:...||....:.:||||:.|:.:.||.|:|||.||:||:||.:.|||.|.|||:||.|||...
  Rat    85 KDLQSDTPLADLWHHDFWGSRLSSNTSHKSYRPLTVLTFRVNYYLSGGFHPVGFHVVNILLHGGI 149

  Fly   131 TALVVRVARTLLASVW-------------AVLAAGALFAAHPIHTEAVAGVVGRADLAACVCYLL 182
            :.|::.|...|...:.             |.|.|..|||.||:|||.||||||||||...:.:||
  Rat   150 SILMLDVFSVLFGGLQYSSKGRRVHLAPRASLLAALLFAVHPVHTECVAGVVGRADLLCALFFLL 214

  Fly   183 TYLSYLRHMRWRESGDPRQ------WLALGATLILAAAGLLCKETAITALLVCALFDVMRGLSGQ 241
            ::|.|.|  .::|:|:...      |:.|  ::.|.|..:||||..:|.|.:.|:||::  :.|:
  Rat   215 SFLGYCR--AFKETGNKEGTHSSTFWVLL--SIFLGAVAMLCKEQGVTVLGLNAVFDIL--VIGR 273

  Fly   242 VD-----------KQRLRSVCIVL--GALFCMA----------YCRLVIVPGPQTAFSSADNPIA 283
            :|           .:.|.|..::.  |.||.||          |.|..|:.....||:..|||.:
  Rat   274 LDILVAVRKVLRKDKSLESTGMLKNGGLLFRMALLTIGGSTMLYIRWKIMGTGPPAFTEVDNPAS 338

  Fly   284 RTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWG 348
            ...|...|.:.:.|....|..|||.|..|.|||.|..:|.:.|:.|.|....|..:..|:|:
  Rat   339 FADSVLVRAINYNYYYSLNAWLLLCPWWLCFDWSMGCIPLIKSVGDWRVIALAALWLCLIGL--- 400

  Fly   349 SCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCR 413

  Rat   401 ----------------------------------------------------------------- 400

  Fly   414 DCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSSS 478
                                           .|:...|..||...
  Rat   401 -------------------------------IFQALCSEDSCKRR-------------------- 414

  Fly   479 LSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVGFC 543
                                     :|.:.|.||.:||||||||.|.||||||||:|||||.|:|
  Rat   415 -------------------------ILTLGLGFLVIPFLPASNLFFRVGFVVAERVLYLPSAGYC 454

  Fly   544 LLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINP--PKALG 606
            :|:.:|...|....::.:.:..:...:|| ..:||.:.|:.:||.|:.|:|||:::.|  .|...
  Rat   455 MLLTFGFGTLSRHTKKKKPVAAIILGILL-INALRCVIRSGEWRSEDRLFRSALSVCPLNAKVHY 518

  Fly   607 NLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKFRPNLAV 671
            |:|..|:.||....|.:..:||:|..|.......|||.:.:.:.....|.|....|::.:|:.|.
  Rat   519 NIGKNLADQGNQTAAIKYYREAVRLNPKYVHAMNNLGNILKERNELQEAEELLSLAVQIQPDFAA 583

  Fly   672 AYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALA 736
            |::||||...:|.:.::|.:           :.|....|.:.....|..||.||.:..:...||.
  Rat   584 AWMNLGIVQNSLKRFEEAEQ-----------SYRTAIKHRRKYPDCYYNLGRLYADLNRHVDALN 637

  Fly   737 IYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLSYGITLARNS 801
            .:|.|....|    :..:.:..:..:|.......:||...|.||:|.||..:...|....|.: |
  Rat   638 AWRNATVMKP----EHSLAWNNMVILLDNTGNLAQAEAVGREALQLIPNDHSLMFSLANVLGK-S 697

  Fly   802 SRASEAEMWFKRALKLAPEQAS-------VYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYTLV 859
            .:..|:|..|.:|:|..|..||       :||.:.. |....:|:|.::      :|.|    :.
  Rat   698 QKYKESEALFLKAIKANPNVASYHGNLAVLYHRWGH-LDSAKKHYEISL------QLDP----VA 751

  Fly   860 VAAATAMRLLDRKVD 874
            |.......||.||::
  Rat   752 VGTKENYSLLRRKLE 766

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	54/138 (39%)
		DUF1736	275..343	CDD:285594	22/67 (33%)
		TPR_11	602..667	CDD:290150	17/64 (27%)
		TPR_1	602..634	CDD:278916	10/31 (32%)
		TPR repeat	602..630	CDD:276809	9/27 (33%)
		TPR repeat	635..665	CDD:276809	6/29 (21%)
		TPR_11	636..700	CDD:290150	15/63 (24%)
		TPR_1	636..668	CDD:278916	6/31 (19%)
		TPR repeat	670..694	CDD:276809	8/23 (35%)
		TPR_11	714..784	CDD:290150	17/69 (25%)
		TPR repeat	715..743	CDD:276809	9/27 (33%)
		TPR repeat	748..782	CDD:276809	6/33 (18%)
		TPR_11	755..819	CDD:290150	17/63 (27%)
		TPR repeat	787..816	CDD:276809	7/28 (25%)
		TPR_11	821..887	CDD:290150	14/61 (23%)
		TPR repeat	822..850	CDD:276809	7/34 (21%)
		TPR repeat	855..885	CDD:276809	5/20 (25%)
		TPR_11	<874..921	CDD:290150	0/1 (0%)
		TPR repeat	890..918	CDD:276809
Tmtc4	XP_006252585.1	DUF1736	324..398	CDD:285594	23/73 (32%)
		TPR	513..771	CDD:223533	70/281 (25%)
		TPR_1	514..547	CDD:278916	11/32 (34%)
		TPR repeat	514..542	CDD:276809	9/27 (33%)
		TPR_17	536..569	CDD:290167	8/32 (25%)
		TPR repeat	547..577	CDD:276809	6/29 (21%)
		TPR_1	582..615	CDD:278916	10/43 (23%)
		TPR repeat	582..610	CDD:276809	9/38 (24%)
		TPR repeat	616..642	CDD:276809	8/25 (32%)
		TPR repeat	650..678	CDD:276809	5/27 (19%)
		TPR repeat	683..713	CDD:276809	7/30 (23%)
		TPR_17	706..739	CDD:290167	9/33 (27%)
		TPR repeat	718..746	CDD:276809	7/34 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.820