DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4341 and IFIT5

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_036552.1	Gene:	IFIT5 / 24138	HGNCID:	13328	Length:	482	Species:	Homo sapiens

Alignment Length:	489	Identity:	92/489 - (18%)
Similarity:	169/489 - (34%)	Gaps:	119/489 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly   523 LFYVGFVVAERLLYLPS---VGFCLLVGY-----GVSK-LMSCNQRTRNILLLSFSLLLAAMSLR 578
            ||.|...:.::|.:|.:   :....|:.|     |.:| .:.|.::...|:....|......||.
Human    31 LFEVEDTIGQQLEFLTTKSRLALYNLLAYVKHLKGQNKDALECLEQAEEIIQQEHSDKEEVRSLV 95

  Fly   579 TLRRNA------DWRDEESLYRSAIAINPPKALGNLGSVLSSQGRYE-EAKQVLQEAIRFRPNMA 636
            |....|      |..:|...|...|        ||:...|||...|: |..:            .
Human    96 TWGNYAWVYYHMDQLEEAQKYTGKI--------GNVCKKLSSPSNYKLECPE------------T 140

  Fly   637 DVHFNLGILHQNQQVYPAAVECFQRAIKFRPN-------LAVAYLNL-------GISFIALGKRQ 687
            |......:|....:.|..|...|::|::..|:       .|:....|       .:...:||..:
Human   141 DCEKGWALLKFGGKYYQKAKAAFEKALEVEPDNPEFNIGYAITVYRLDDSDREGSVKSFSLGPLR 205

  Fly   688 QAIEILQAGSNLDGA------AVRDRTAHDQARSSAYLQ---------------LGALYVEQGKL 731
            :|:.:     |.|.:      |::.:..|.:|....|::               ....|..:...
Human   206 KAVTL-----NPDNSYIKVFLALKLQDVHAEAEGEKYIEEILDQISSQPYVLRYAAKFYRRKNSW 265

  Fly   732 QRALAIYREALSSLPG---LPQQREILYQ--------------------RIGDVLGRLQQWDEAE 773
            .:||.:.::||...|.   |..|..:.|:                    ::.:::      ..|.
Human   266 NKALELLKKALEVTPTSSFLHHQMGLCYRAQMIQIKKATHNRPKGKDKLKVDELI------SSAI 324

  Fly   774 RHHRAALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLA----PEQASVYHHYAEFLSL 834
            .|.:||:|.......|:.... .:.....:.|.||..|::||:|.    ..:..:::||..|...
Human   325 FHFKAAMERDSMFAFAYTDLA-NMYAEGGQYSNAEDIFRKALRLENITDDHKHQIHYHYGRFQEF 388

  Fly   835 QSRHHESAIYHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAI 899
            ..:...:||:|...|....:...|.....:|::.|.         .|.:.....|..:.:.||.:
Human   389 HRKSENTAIHHYLEALKVKDRSPLRTKLTSALKKLS---------TKRLCHNALDVQSLSALGFV 444

  Fly   900 LHLLGRTNHAAASYKAALRLQPGDAITLGNLAKL 933
            ..|.|....||..|:.|.::.|.:|..|..|.:|
Human   445 YKLEGEKRQAAEYYEKAQKIDPENAEFLTALCEL 478

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453
		DUF1736	275..343	CDD:285594
		TPR_11	602..667	CDD:290150	13/65 (20%)
		TPR_1	602..634	CDD:278916	7/32 (22%)
		TPR repeat	602..630	CDD:276809	7/28 (25%)
		TPR repeat	635..665	CDD:276809	6/29 (21%)
		TPR_11	636..700	CDD:290150	13/77 (17%)
		TPR_1	636..668	CDD:278916	6/31 (19%)
		TPR repeat	670..694	CDD:276809	5/30 (17%)
		TPR_11	714..784	CDD:290150	15/107 (14%)
		TPR repeat	715..743	CDD:276809	5/42 (12%)
		TPR repeat	748..782	CDD:276809	7/53 (13%)
		TPR_11	755..819	CDD:290150	14/87 (16%)
		TPR repeat	787..816	CDD:276809	6/28 (21%)
		TPR_11	821..887	CDD:290150	11/65 (17%)
		TPR repeat	822..850	CDD:276809	6/27 (22%)
		TPR repeat	855..885	CDD:276809	4/29 (14%)
		TPR_11	<874..921	CDD:290150	10/46 (22%)
		TPR repeat	890..918	CDD:276809	8/27 (30%)
IFIT5	NP_036552.1	TPR_12	49..116	CDD:315987	13/66 (20%)
		TPR 1	51..84		6/32 (19%)
		TPR repeat	53..79	CDD:276809	5/25 (20%)
		TPR repeat	84..133	CDD:276809	14/56 (25%)
		TPR 2	94..127		9/40 (23%)
		TPR 3	138..173		7/46 (15%)
		TPR repeat	138..168	CDD:276809	6/41 (15%)
		PEP_TPR_lipo	<157..470	CDD:274350	58/333 (17%)
		TPR 4	181..214		6/37 (16%)
		TPR repeat	214..244	CDD:276809	4/29 (14%)
		TPR 5	249..282		6/32 (19%)
		TPR repeat	249..277	CDD:276809	4/27 (15%)
		Interaction with the 5'-triphosphate group of PPP-RNA	254..260		0/5 (0%)
		TPR repeat	282..333	CDD:276809	7/56 (13%)
		TPR 6	338..371		8/33 (24%)
		TPR repeat	338..366	CDD:276809	6/28 (21%)
		TPR 7	376..410		7/33 (21%)
		TPR repeat	376..405	CDD:276809	7/28 (25%)
		TPR 8	435..468		9/32 (28%)
		TPR repeat	435..463	CDD:276809	8/27 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810