DRSC/TRiP Functional Genomics Resources

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Protein Alignment Tmtc2 and Tmtc3

DIOPT Version :10

Sequence 1:NP_608558.1 Gene:Tmtc2 / 33276 FlyBaseID:FBgn0028481 Length:938 Species:Drosophila melanogaster
Sequence 2:NP_001103483.1 Gene:Tmtc3 / 237500 MGIID:3036255 Length:920 Species:Mus musculus


Alignment Length:950 Identity:251/950 - (26%)
Similarity:380/950 - (40%) Gaps:279/950 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    40 SLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLCVLSF 104
            |:....|.|:|..|||:||..|||.|.|:...||.:..|.|||||||:::..||.|:|||.||:|
Mouse    19 SVVAACYWNSLFCGFVFDDVSAILDNKDLHPSTPLKTLFQNDFWGTPMSEERSHKSYRPLTVLTF 83

  Fly   105 RLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAVAGVV 169
            |||||: ....|..:||:|.:.|.|.:.:.::|.|..|....:::|| .|||.||||||||.|||
Mouse    84 RLNYLL-SELKPMSYHLLNTVFHAVVSVIFLKVCRLFLDKRSSMIAA-LLFAVHPIHTEAVTGVV 146

  Fly   170 GRADLAACVCYLLTYLSYLRHMRWRESGDPRQ---WLALGATLILAAAGLLCKETAITALLVCAL 231
            |||:|.:.|.:|..:|||.:      |..|..   |..:..|:.|.|...||||..||.:.:|.:
Mouse   147 GRAELLSSVFFLAAFLSYTK------SKGPDNSIVWTPIVLTVFLVAVATLCKEQGITVVGICCV 205

  Fly   232 FDV------------------MRGLSGQVDKQRLRS----VCIVLGALFCMAYCRLVIVPGPQTA 274
            ::|                  :|| .|.:....|::    :.::|..|. :...|:.::......
Mouse   206 YEVFVAQGYTLPMLCTVAGQFLRG-KGSIPLSMLQTLVKLIVLMLSTLL-LVVVRVQVIQSQLPV 268

  Fly   275 FSSADNPIARTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFY 339
            |:..|||.|.:|:. ||.|||.||...|..|||.|:.|..||.|..:|.:.|..|.||..:..|:
Mouse   269 FTRFDNPAAVSPTP-TRQLTFNYLLPVNAWLLLNPSELCCDWTMGTIPLIESFLDVRNLATFAFF 332

  Fly   340 SVLVGVAWGSCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQ 404
            ..|..:...|.|                                                     
Mouse   333 CFLGALGIFSLR----------------------------------------------------- 344

  Fly   405 QQQEALPCRDCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSS 469
                                |.|.                                         
Mouse   345 --------------------YPGD----------------------------------------- 348

  Fly   470 SSSSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERL 534
                            |||               .::|:|..:||||:|||||.|.||||||||:
Mouse   349 ----------------SSK---------------TVLMALCLMALPFIPASNLFFPVGFVVAERV 382

  Fly   535 LYLPSVGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAI 599
            ||:||:|||:||.:|..|: |.....:.:..:..|:::...:|:||.||.||..|.:|:.||:.:
Mouse   383 LYVPSMGFCILVAHGWQKI-SNKSVLKKLSWVCLSMVILTHALKTLHRNWDWESEYTLFMSALKV 446

  Fly   600 NP--PKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQN-------------- 648
            |.  .|...|:|..|.::..:|:|.:...:|...:|:....|.|:|..::|              
Mouse   447 NKNNAKLWNNVGHALENEKNFEKALKYFLQATHVQPDDIGAHMNVGRTYKNLNRTREAEASYMLA 511

  Fly   649 QQVYPAAVECFQRAIKFRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQA 713
            :.:.|..:...:.|.:..||....|:||.....|...|      |:....|...|:..|....| 
Mouse   512 KSLMPQIIPGKKYAARIAPNHLNVYINLANLIRANESR------LEEADQLYRQAISMRPDFKQ- 569

  Fly   714 RSSAYLQLGALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRA 778
               ||:..|.|.::..|..:|...|.:||.    |.:....|:..:..|...|::.:||.::...
Mouse   570 ---AYISRGELLLKMNKPLKAKEAYLKALE----LDRNNADLWYNLAIVYIELKEPNEALKNFNR 627

  Fly   779 ALELQPNQVAAHLSYGI------------------------------------TLARNSSRASEA 807
            ||||.|....|..:..|                                    .||.:..:.|||
Mouse   628 ALELNPKHKLALFNSAILMQESGEVKLRPEARKRLLNYVNEEPQDANGYFNLGMLAMDDKKDSEA 692

  Fly   808 EMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAP-----------NDYT--LV 859
            |.|.|:|:||.|:..|...:.|            .:|.:.|.||..           .|:|  |:
Mouse   693 ESWMKKAIKLQPDFRSALFNLA------------LLYSQTAKELKALPILEELLKYYPDHTKGLI 745

  Fly   860 VAAATAMRLLDRKVD---AEMWYRKAVALRPGDAHAHTNL 896
            :....   |:::|.|   |:..:.|.:.:.|.:.....||
Mouse   746 LKGDI---LMNQKKDIPGAKKCFEKILEMDPSNVQGKHNL 782

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Tmtc2NP_608558.1 TMTC_DUF1736 270..343 CDD:462468 28/72 (39%)
TPR 597..852 CDD:440225 66/306 (22%)
TPR repeat 602..630 CDD:276809 7/27 (26%)
TPR repeat 635..665 CDD:276809 6/43 (14%)
TPR repeat 670..694 CDD:276809 5/23 (22%)
TPR repeat 715..743 CDD:276809 8/27 (30%)
TPR repeat 748..782 CDD:276809 8/33 (24%)
TPR 780..>933 CDD:440225 34/168 (20%)
TPR repeat 787..816 CDD:276809 11/64 (17%)
TPR repeat 822..850 CDD:276809 4/27 (15%)
TPR repeat 855..885 CDD:276809 8/34 (24%)
TPR repeat 890..918 CDD:276809 1/6 (17%)
Tmtc3NP_001103483.1 TMTC_DUF1736 263..336 CDD:462468 28/73 (38%)
TPR 444..673 CDD:440225 49/242 (20%)
TPR 1. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 451..484 8/32 (25%)
TPR repeat 451..479 CDD:276809 7/27 (26%)
TPR repeat 484..528 CDD:276809 6/43 (14%)
TPR 2. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 485..518 5/32 (16%)
TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 534..567 9/38 (24%)
TPR repeat 535..562 CDD:276809 8/32 (25%)
LapB 549..804 CDD:442196 56/262 (21%)
TPR repeat 567..597 CDD:276809 10/37 (27%)
TPR 4. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 568..601 11/40 (28%)
TPR 5. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 602..635 10/32 (31%)
TPR repeat 602..630 CDD:276809 6/27 (22%)
TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 673..706 12/32 (38%)
TPR repeat 673..702 CDD:276809 9/28 (32%)
TPR 7. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 707..740 6/44 (14%)
TPR repeat 707..735 CDD:276809 6/39 (15%)
TPR repeat 741..770 CDD:276809 7/31 (23%)
TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 742..775 7/35 (20%)
TPR 9. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339 776..809 1/6 (17%)
TPR repeat 776..799 CDD:276809 1/6 (17%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 829..897
Blue background indicates that the domain is not in the aligned region.

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