Protein Alignment Tmtc2 and KDM6B

DIOPT Version :10

• Sequence 1: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_001073893.1
• Gene: KDM6B / 23135
• HGNCID: 29012
• Length: 1682
• Species: Homo sapiens
• Alignment Length: 126
• Identity: 36/126 - (28%)
• Similarity: 49/126 - (38%)
• Gaps: 22/126 - (17%)

  Fly   415 CNNNNSSGYVYE-----GSSPVAQAPAQAPHLVSSAFRG---SRSSSSCSNS----TNSSSSSSS 467
            |......|.:.|     ...|...||...||  ...|.|   ||.|....:|    |..:.::||
Human   491 CRAAREDGEILEELFFGTEGPPRPAPPPLPH--REGFLGPPASRFSVGTQDSHTPPTPPTPTTSS 553

  Fly   468 SSSSSSSSSSSLSGGFQCSSKDYALEGM-------SPANRHACVLIMSLSFLALPFLPASN 521
            |:|:|.|.|||.:|........|....:       |||.......::.|: ||||..|.|:
Human   554 SNSNSGSHSSSPAGPVSFPPPPYLARSIDPLPRPPSPAQNPQDPPLVPLT-LALPPAPPSS 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468
		TPR	597..852	CDD:440225
		TPR repeat	602..630	CDD:276809
		TPR repeat	635..665	CDD:276809
		TPR repeat	670..694	CDD:276809
		TPR repeat	715..743	CDD:276809
		TPR repeat	748..782	CDD:276809
		TPR	780..>933	CDD:440225
		TPR repeat	787..816	CDD:276809
		TPR repeat	822..850	CDD:276809
		TPR repeat	855..885	CDD:276809
		TPR repeat	890..918	CDD:276809
KDM6B	NP_001073893.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	52..88
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..680		36/126 (29%)
		PRK12323	<572..718	CDD:481241	11/43 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	704..807
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	822..1096
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1288..1325
		JmjC	1343..1407	CDD:214721
		JmjC	1377..1485	CDD:396791