DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and F38B6.6

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_509123.2	Gene:	F38B6.6 / 185454	WormBaseID:	WBGene00018175	Length:	690	Species:	Caenorhabditis elegans

Alignment Length:	819	Identity:	211/819 - (25%)
Similarity:	339/819 - (41%)	Gaps:	223/819 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLC 100
            |...||:.:.||:.||..||:||..:|:.|..|:|..|..:.||.||||..::.|.||.|:||:.
Worm    33 LILISLSIIPYLSCLGGDFVFDDAESIVNNPIVNGKDPLLQIFSRDFWGRSISSSNSHKSYRPVT 97

  Fly   101 VLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTL--------LASVWAVLAAGALFAA 157
            ..:|.|||.: ...:..|:|:||.:.|.|||.:..::.:.|        :|     .:|..|||.
Worm    98 TFTFWLNYKL-HETSTLGYHVVNIICHTVATLVFYKLGKQLEHIFDFFNIA-----FSASILFAV 156

  Fly   158 HPIHTEAVAGVVGRADLAACVCYLLTYLS---YLRHMRWRESGDPRQWLALGATLILAAAGLLCK 219
            ||:||||||.:.|||:|      |:|..|   .:.|::.||..        ...::|.....|.|
Worm   157 HPVHTEAVANITGRAEL------LMTIFSLAALILHVKNREIN--------CKFVLLVILSTLSK 207

  Fly   220 ETAITALLVCALFDVMRGLSGQVDKQRLRSVCIVLGALFCMAYCRLVIVPGPQTAFSSADNPIAR 284
            |..:..:.:....|.:...|.:  ...:|.:|:    |..:.:.|:::.......|:..|||.|.
Worm   208 EQGLMTIPIAICIDFLAHRSCR--SNFVRMICL----LVAIGFLRMMVNGFEAAKFTKLDNPTAF 266

  Fly   285 TPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYS-VLVGVAWG 348
            ..|.:.|::.:.|:.:::..||:.|..|.||:.|..:..:|::||.|.......:: |::||
Worm   267 LNSKFYRMINYTYIWLYHAYLLVIPVNLCFDYSMGCISSITTMWDLRALSPVLIFTIVIIGV--- 328

  Fly   349 SCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCR 413
                                                         |:|                .
Worm   329 ---------------------------------------------KFQ----------------N 332

  Fly   414 DCNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSSS 478
            :|.                            ||                            :.||
Worm   333 ECR----------------------------AF----------------------------TLSS 341

  Fly   479 LSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVGFC 543
            |.|                               .:.||||||:.|.|||.:|||:|||||.|||
Worm   342 LMG-------------------------------IISFLPASNIFFTVGFSIAERVLYLPSAGFC 375

  Fly   544 LLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINPPKAL--G 606
            ||......||   :...:|..:||.:|:|..:| :|.||:.:|:.|.|||.|.:::.|..|.  .
Worm   376 LLCAIIFKKL---SVHFKNADVLSITLILLLIS-KTYRRSGEWKTELSLYSSGLSVCPTNAKIHY 436

  Fly   607 NLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIKFRPNLAV 671
            |||.||...|..::|::....||:..|:......|||.|.:.......|.....||:..||:.||
Worm   437 NLGKVLGDNGLTKDAEKNYWNAIKLDPSYEQALNNLGNLLEKSGDSKTAESLLARAVTLRPSFAV 501

  Fly   672 AYLNLGISFIALGKRQQA--------------------IEILQAGSNLDGAAV---RDRTAHDQA 713
            |::|||||.:.|.|..:|                    :.:|...:|.|..|:   ::.|..|.:
Worm   502 AWMNLGISQMNLKKYYEAEKSLKNSLLIRPNSAHCLFNLGVLYQRTNRDEMAMSAWKNATRIDPS 566

  Fly   714 RSSAYLQLGALYVEQGKLQRALAIYREALSSLPGLPQQREILYQRIGDVLGRLQQWDEAERHHRA 778
            .|.::..|..:.....:..:.:.:..:||||:|.  :.|  ::.:||....:...:..||.|.::
Worm   567 HSQSWTNLFVVLDHLSQCSQVIDLSYQALSSVPN--ESR--VHMQIGSCHAKHSNFTAAENHIKS 627

  Fly   779 ALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKL 817
            |::|.|..|..|.:.|| |.:..||..|||..::..|.|
Worm   628 AIDLNPTSVLFHANLGI-LYQRMSRHKEAESQYRIVLAL 665

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	36/130 (28%)
		DUF1736	275..343	CDD:285594	20/68 (29%)
		TPR_11	602..667	CDD:290150	18/66 (27%)
		TPR_1	602..634	CDD:278916	10/33 (30%)
		TPR repeat	602..630	CDD:276809	9/29 (31%)
		TPR repeat	635..665	CDD:276809	7/29 (24%)
		TPR_11	636..700	CDD:290150	22/83 (27%)
		TPR_1	636..668	CDD:278916	8/31 (26%)
		TPR repeat	670..694	CDD:276809	11/43 (26%)
		TPR_11	714..784	CDD:290150	15/69 (22%)
		TPR repeat	715..743	CDD:276809	3/27 (11%)
		TPR repeat	748..782	CDD:276809	7/33 (21%)
		TPR_11	755..819	CDD:290150	20/63 (32%)
		TPR repeat	787..816	CDD:276809	10/28 (36%)
		TPR_11	821..887	CDD:290150
		TPR repeat	822..850	CDD:276809
		TPR repeat	855..885	CDD:276809
		TPR_11	<874..921	CDD:290150
		TPR repeat	890..918	CDD:276809
F38B6.6	NP_509123.2	DUF1736	251..325	CDD:285594	19/73 (26%)
		TPR_11	431..497	CDD:290150	18/65 (28%)
		TPR_1	432..465	CDD:278916	11/32 (34%)
		TPR repeat	432..460	CDD:276809	9/27 (33%)
		TPR_17	455..486	CDD:290167	7/30 (23%)
		TPR_11	467..531	CDD:290150	20/63 (32%)
		TPR repeat	467..494	CDD:276809	7/26 (27%)
		TPR repeat	499..529	CDD:276809	11/29 (38%)
		TPR_11	500..565	CDD:290150	16/64 (25%)
		TPR_1	500..532	CDD:278916	11/31 (35%)
		TPR repeat	534..560	CDD:276809	4/25 (16%)
		TPR repeat	568..596	CDD:276809	3/27 (11%)
		TPR_11	601..666	CDD:290150	21/68 (31%)
		TPR repeat	601..631	CDD:276809	7/31 (23%)
		TPR repeat	636..664	CDD:276809	10/28 (36%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.820