DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and F32D1.3

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_504200.1	Gene:	F32D1.3 / 178832	WormBaseID:	WBGene00017983	Length:	774	Species:	Caenorhabditis elegans

Alignment Length:	921	Identity:	269/921 - (29%)
Similarity:	414/921 - (44%)	Gaps:	189/921 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 SNMDFTCLFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSF--SNDFWGTPLTDSG 91
            |::.:..|.....|.::|..||.|.||||||.|||.|.||.|.||| ||.  .|||||.|:...|
Worm    17 SHIPYQYLLVALFASIVYRITLNADFVYDDRPAILTNDDVLGRTPW-RSLIVHNDFWGNPIGLQG 80

  Fly    92 SHGSWRPLCVLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVAR--TLLASVWAVLAAGAL 154
            ||.|:|||...||||.:.:.|..|.. ||.||.:.|.:.:.||:::||  .::.:.:::|:| .:
Worm    81 SHKSYRPLITASFRLQFAVHGLKAEL-FHGVNLICHMINSMLVLKLARQMRIMGNEFSLLSA-LI 143

  Fly   155 FAAHPIHTEAVAGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQWLALGATLILAAAGLLCK 219
            ||.|||.:|||..:||||||.:.:..||....:        :.||..:    .|::|:...:..|
Worm   144 FACHPITSEAVCSIVGRADLLSTMLILLAITCH--------TSDPSTF----RTIVLSILAVTAK 196

  Fly   220 ETAITALLVCALFDVMRGLSGQVDKQRLRSVCIVLGALFCMAYCRLVIVPGPQTAFSSADNPIAR 284
            ||.|..|.:..|:||:...|.  .||..|.|...|.:|..:.|.||.|.......||..|||||.
Worm   197 ETGIILLPLITLYDVLFKTSN--TKQFRRDVTAYLISLLALCYLRLSINNFQSPKFSKNDNPIAH 259

  Fly   285 TPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWGS 349
            .|::.||.|||:|||||:|.|::.|..||:||.|||:|:|.||.|.|    .....:::||
Worm   260 EPNSLTRALTFMYLPVFHLNLIVFPKTLSYDWSMDAIPKVESLIDSR----IILTFIVIGV---- 316

  Fly   350 CRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCRD 414

Worm   317 ----------------------------------------------------------------- 316

  Fly   415 CNNNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSSSSSSSSSL 479
                                   ..|::.....|.|      ||.||..:.|
Worm   317 -----------------------GEHVLLKLLLGLR------NSENSHENRS------------- 339

  Fly   480 SGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLYLPSVGFCL 544
                                     |:...:....|.:.:||||.:||||.|||:|||.:|.:|:
Worm   340 -------------------------LLFLFALFTTPHILSSNLLTHVGFVAAERILYLNTVAYCI 379

  Fly   545 LVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAINPPKALGNLG 609
            |..: ::::.|.....:::|.| :.|||:..::||::|..||:.||||::||:.:||.||..|||
Worm   380 LAAF-LAEMCSKRSSPKSVLPL-YILLLSLFTIRTMQRVDDWKTEESLFKSALEVNPTKANMNLG 442

  Fly   610 SVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGIL-HQNQQVYPAAVECFQRAIKFRPNLAVAY 673
            .|.::|.:||.||...::|::.:.|:||..:||||| .:.......::.|:|.|::.|...|.|:
Worm   443 YVYTTQKKYELAKYHYRQALKRQGNLADAWYNLGILTSKTSNNSNGSIHCYQMALQSRSTYAAAH 507

  Fly   674 LNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALAIY 738
            |||.:.....|....|...|....|..|..::....:.:.:::.....|.|..:.|....|:..:
Worm   508 LNLALLLHDAGHHMAAFSHLDKCLNNTGEFLKFYHVNRKTQATCAFNKGRLLQKSGNFHVAIENF 572

  Fly   739 REAL-------SSLPGLPQQREILYQRIGDVLGRLQQWDEA--ERHHRAALELQPNQVAAHLSYG 794
            ..||       ...|.:.......|..:||.....:.:.:|  |.|..:.|.:      |||..
Worm   573 ELALKLGGPHFEHTPSVLNSMGTCYNELGDEQSAEKFFGKAIGENHVNSYLTM------AHLKI- 630

  Fly   795 ITLARNSSRASEAEMWFKRALKLAPEQASVYHH--YAEFLSLQSRHHESAIYHRRAAELAPNDYT 857
                 ..:|:.|.|...::|:.||||..:|..:  .||| .:|: ::.|.:::|:|..|.|....
Worm   631 -----RQNRSFEVENLLRKAMTLAPESVTVLQNIALAEF-HMQN-YNRSLLFYRKALHLDPTHLD 688

  Fly   858 LVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPG 922
            .:...|..::.....|::|.:|||.:..:|....||.|.||||||..:.:.|...|:.||.|.|.
Worm   689 SLQGIANLLQQTQNHVESETFYRKVMEAQPNSYAAHANYGAILHLNQKYDLALKEYEIALILDPT 753

  Fly   923 DAITLGNLAKL 933
            ..:...|..|:
Worm   754 SDVARENRKKV 764

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	38/121 (31%)
		DUF1736	275..343	CDD:285594	34/67 (51%)
		TPR_11	602..667	CDD:290150	23/65 (35%)
		TPR_1	602..634	CDD:278916	12/31 (39%)
		TPR repeat	602..630	CDD:276809	12/27 (44%)
		TPR repeat	635..665	CDD:276809	10/30 (33%)
		TPR_11	636..700	CDD:290150	20/64 (31%)
		TPR_1	636..668	CDD:278916	11/32 (34%)
		TPR repeat	670..694	CDD:276809	7/23 (30%)
		TPR_11	714..784	CDD:290150	14/78 (18%)
		TPR repeat	715..743	CDD:276809	6/34 (18%)
		TPR repeat	748..782	CDD:276809	7/35 (20%)
		TPR_11	755..819	CDD:290150	15/65 (23%)
		TPR repeat	787..816	CDD:276809	7/28 (25%)
		TPR_11	821..887	CDD:290150	16/67 (24%)
		TPR repeat	822..850	CDD:276809	8/29 (28%)
		TPR repeat	855..885	CDD:276809	6/29 (21%)
		TPR_11	<874..921	CDD:290150	19/46 (41%)
		TPR repeat	890..918	CDD:276809	12/27 (44%)
F32D1.3	NP_504200.1	DUF1736	244..316	CDD:369859	34/75 (45%)
		TPR repeat	436..464	CDD:276809	12/27 (44%)
		TPR	448..748	CDD:223533	81/313 (26%)
		TPR repeat	469..498	CDD:276809	10/28 (36%)
		TPR repeat	504..531	CDD:276809	8/26 (31%)
		TPR repeat	537..578	CDD:276809	6/40 (15%)
		TPR repeat	587..614	CDD:276809	4/26 (15%)
		TPR repeat	619..647	CDD:276809	8/39 (21%)
		TPR repeat	655..681	CDD:276809	8/27 (30%)
		TPR repeat	686..716	CDD:276809	6/29 (21%)
		TPR repeat	721..748	CDD:276809	11/26 (42%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160159197
Domainoid	1	1.000	136	1.000	Domainoid score	I3058
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25521
Inparanoid	1	1.050	388	1.000	Inparanoid score	I1149
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG52430
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0004694
OrthoInspector	1	1.000	-	-		otm14099
orthoMCL	1	0.900	-	-		OOG6_106232
Panther	1	1.100	-	-	LDO	PTHR44216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4791
SonicParanoid	1	1.000	-	-		X3302
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.800