DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4341 and TMTC2

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_689801.1	Gene:	TMTC2 / 160335	HGNCID:	25440	Length:	836	Species:	Homo sapiens

Alignment Length:	921	Identity:	340/921 - (36%)
Similarity:	482/921 - (52%)	Gaps:	126/921 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 LFCCSLAFVLYLNTLGAGFVYDDRRAILANADVSGGTPWQRSFSNDFWGTPLTDSGSHGSWRPLC 100
            |...:|...||||||.|.|.|||.|||..|.|:...|||...|.||||||.||.||||.|:||||
Human     5 LVSSALGLALYLNTLSADFCYDDSRAIKTNQDLLPETPWTHIFYNDFWGTLLTHSGSHKSYRPLC 69

  Fly   101 VLSFRLNYLIGGGFAPWGFHLVNNLLHCVATALVVRVARTLLASVWAVLAAGALFAAHPIHTEAV 165
            .||||||:.| ||..||.:||||.|||...|.|....::.||...:....||.:||:||||||||
Human    70 TLSFRLNHAI-GGLNPWSYHLVNVLLHAAVTGLFTSFSKILLGDGYWTFMAGLMFASHPIHTEAV 133

  Fly   166 AGVVGRADLAACVCYLLTYLSYLRHMRWRESGDPRQW-LALGATLILAAAGLLCKETAITALLVC 229
            ||:|||||:.|.:.:||:.|.|::|...| ....|.| ..||:.| .|...:|.||..:|.|.|.
Human   134 AGIVGRADVGASLFFLLSLLCYIKHCSTR-GYSARTWGWFLGSGL-CAGCSMLWKEQGVTVLAVS 196

  Fly   230 ALFDV-------MRGLSGQVDKQRLRSVCIVLGALF----CMAYCRLVIVPGPQTAFSSADNPIA 283
            |::||       ::.:...:.|::..|:.:.:..|.    .:...||..:.....:||::|||.|
Human   197 AVYDVFVFHRLKIKQILPTIYKRKNLSLFLSISLLIFWGSSLLGARLYWMGNKPPSFSNSDNPAA 261

  Fly   284 RTPSAWTRLLTFLYLPVFNLRLLLQPNVLSFDWGMDALPRVTSLWDRRNAQSACFYSVLVGVAWG 348
            .:.|..||.|||.|||..||.|||.|:.|||||.|||:|.:.::.|.||..:..||:.|:
Human   262 DSDSLLTRTLTFFYLPTKNLWLLLCPDTLSFDWSMDAVPLLKTVCDWRNLHTVAFYTGLL----- 321

  Fly   349 SCRQLLSGSKEVTHCGVSSTFPQYHIQKVASRKSRSKRKRLANNTKYQAFEAAYHQQQQEALPCR 413
                ||                                              ||:..:..::. |
Human   322 ----LL----------------------------------------------AYYGLKSPSVD-R 335

  Fly   414 DCN-------NNNSSGYVYEGSSPVAQAPAQAPHLVSSAFRGSRSSSSCSNSTNSSSSSSSSSSS 471
            :||       ..|::|:                              ||     .|.....:|.:
Human   336 ECNGKTVTNGKQNANGH------------------------------SC-----LSDVEYQNSET 365

  Fly   472 SSSSSSSLSGGFQCSSKDYALEGMSPANRHACVLIMSLSFLALPFLPASNLLFYVGFVVAERLLY 536
            .||.:|.:..|.:   .|.:.....|:..:  ::::|||.|.:||:||:||.||||||:|||:||
Human   366 KSSFASKVENGIK---NDVSQRTQLPSTEN--IVVLSLSLLIIPFVPATNLFFYVGFVIAERVLY 425

  Fly   537 LPSVGFCLLVGYGVSKLMSCNQR--TRNILLLSFSLLLAAMSLRTLRRNADWRDEESLYRSAIAI 599
            :||:|||||:..|...|....|:  .::::..:.:.|:....|:|..||.||::||.||||.|.:
Human   426 IPSMGFCLLITVGARALYVKVQKRFLKSLIFYATATLIVFYGLKTAIRNGDWQNEEMLYRSGIKV 490

  Fly   600 NPPKALGNLGSVLSSQGRYEEAKQVLQEAIRFRPNMADVHFNLGILHQNQQVYPAAVECFQRAIK 664
            ||.||.||||:||.||.:..||:...:.|:.:|.||||:.:|||:|.|....:..|:..::.||.
Human   491 NPAKAWGNLGNVLKSQSKISEAESAYRNALYYRSNMADMLYNLGLLLQENSRFAEALHYYKLAIG 555

  Fly   665 FRPNLAVAYLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQG 729
            .||.||.||||.||..:..|:.::|.......|.:....::|..||..:.:|....||.||.|||
Human   556 SRPTLASAYLNTGIILMNQGRTEEARRTFLKCSEIPDENLKDPHAHKSSVTSCLYNLGKLYHEQG 620

  Fly   730 KLQRALAIYREALSSLPG--LPQQREILYQRIGDVLGRLQQWDEAERHHRAALELQPNQVAAHLS 792
            ..:.||::|:||:..:|.  .||.   ||..:|:...||.:..|||..:..:|..:.:.:.|||:
Human   621 HYEEALSVYKEAIQKMPRQFAPQS---LYNMMGEAYMRLSKLPEAEHWYMESLRSKTDHIPAHLT 682

  Fly   793 YGITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQSRHHESAIYHRRAAELAPNDYT 857
            ||..||. :.|.||||..|.:|::|.|.:.:.|.||.:||..::|..|:|...::||||...::.
Human   683 YGKLLAL-TGRKSEAEKLFLKAIELDPTKGNCYMHYGQFLLEEARLIEAAEMAKKAAELDSTEFD 746

  Fly   858 LVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRTNHAAASYKAALRLQPG 922
            :|..||..:|.......||.:|..|..|||....|..||||||||.||...|.|:|..||:|:|.
Human   747 VVFNAAHMLRQASLNEAAEKYYDLAARLRPNYPAALMNLGAILHLNGRLQKAEANYLRALQLKPD 811

  Fly   923 DAITLGNLAKL 933
            |.||..||.||
Human   812 DVITQSNLRKL 822

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453	54/120 (45%)
		DUF1736	275..343	CDD:285594	35/67 (52%)
		TPR_11	602..667	CDD:290150	26/64 (41%)
		TPR_1	602..634	CDD:278916	14/31 (45%)
		TPR repeat	602..630	CDD:276809	13/27 (48%)
		TPR repeat	635..665	CDD:276809	11/29 (38%)
		TPR_11	636..700	CDD:290150	23/63 (37%)
		TPR_1	636..668	CDD:278916	11/31 (35%)
		TPR repeat	670..694	CDD:276809	9/23 (39%)
		TPR_11	714..784	CDD:290150	25/71 (35%)
		TPR repeat	715..743	CDD:276809	13/27 (48%)
		TPR repeat	748..782	CDD:276809	11/33 (33%)
		TPR_11	755..819	CDD:290150	24/63 (38%)
		TPR repeat	787..816	CDD:276809	14/28 (50%)
		TPR_11	821..887	CDD:290150	21/65 (32%)
		TPR repeat	822..850	CDD:276809	9/27 (33%)
		TPR repeat	855..885	CDD:276809	8/29 (28%)
		TPR_11	<874..921	CDD:290150	24/46 (52%)
		TPR repeat	890..918	CDD:276809	15/27 (56%)
TMTC2	NP_689801.1	DUF1736	247..318	CDD:285594	34/70 (49%)
		TPR 1	462..492		14/29 (48%)
		TPR_11	493..554	CDD:290150	24/60 (40%)
		TPR 2	493..526		14/32 (44%)
		TPR repeat	493..521	CDD:276809	13/27 (48%)
		TPR_1	493..>520	CDD:278916	12/26 (46%)
		TPR 3	527..560		12/32 (38%)
		TPR repeat	527..555	CDD:276809	9/27 (33%)
		TPR_12	557..634	CDD:290160	29/76 (38%)
		TPR repeat	560..590	CDD:276809	11/29 (38%)
		TPR 4	562..594		9/31 (29%)
		TPR repeat	595..634	CDD:276809	16/38 (42%)
		TPR 5	606..639		14/32 (44%)
		TPR_2	609..638	CDD:285020	12/28 (43%)
		TPR repeat	642..671	CDD:276809	10/31 (32%)
		TPR 6	643..676		10/35 (29%)
		TPR_11	645..708	CDD:290150	24/63 (38%)
		TPR 7	677..710		16/33 (48%)
		TPR repeat	679..705	CDD:276809	14/26 (54%)
		TPR repeat	710..774	CDD:276809	20/63 (32%)
		TPR 8	712..744		12/31 (39%)
		TPR 9	746..778		11/31 (35%)
		TPR_19	755..822	CDD:291240	31/66 (47%)
		TPR 10	779..812		18/32 (56%)
		TPR_1	779..812	CDD:278916	18/32 (56%)
		TPR repeat	779..807	CDD:276809	15/27 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	188	1.000	Domainoid score	I3317
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H25521
Inparanoid	1	1.050	560	1.000	Inparanoid score	I1100
Isobase	1	0.950	-	0	Normalized mean entropy	S4190
OMA	1	1.010	-	-		QHG52430
OrthoDB	1	1.010	-	-		D1320023at2759
OrthoFinder	1	1.000	-	-		FOG0004694
OrthoInspector	1	1.000	-	-		otm42083
orthoMCL	1	0.900	-	-		OOG6_106232
Panther	1	1.100	-	-	LDO	PTHR44216
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4791
SonicParanoid	1	1.000	-	-		X3302
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	16	15.820