Protein Alignment Tmtc2 and Ifit1

DIOPT Version :10

• Sequence 1: NP_608558.1
• Gene: Tmtc2 / 33276
• FlyBaseID: FBgn0028481
• Length: 938
• Species: Drosophila melanogaster
• Sequence 2: NP_032357.2
• Gene: Ifit1 / 15957
• MGIID: 99450
• Length: 463
• Species: Mus musculus
• Alignment Length: 403
• Identity: 82/403 - (20%)
• Similarity: 159/403 - (39%)
• Gaps: 77/403 - (19%)

  Fly   576 SLRTLRRNADWRDEESLYRSAIAINPPKALGNL-------GSVLSSQGRYEEAKQVLQE---AIR 630
            :|::|:........|.|.:.::|     ..||.       ||:..:|...::.::|.:|   ..|
Mouse    71 ALQSLKEAEALIQSEQLSKRSLA-----TWGNCAWLHYHRGSLAEAQIYLDKVEKVCKEFSSPFR 130

  Fly   631 FRPNMADVHFNLG--ILHQNQQVYPAAVECFQRAIKFRPN--------LAVAY-LNLGISFIALG 684
            :|...|::....|  :|......|..|:.||.:|:|..|.        ..||| .:|..:||:|.
Mouse   131 YRLECAEMDCEEGWALLKCGGGNYKQAMACFAKALKVEPENPEYNTGYAVVAYRQDLDDNFISLE 195

  Fly   685 KRQQAIEI--------------LQ-AGSNLDGAAVRDRTAHDQARSSAYLQLGALYV-EQGKLQR 733
            ..::|:.:              || .|.:::..|..:......:..|..::..|.|. .:.::.:
Mouse   196 PLRKAVRLNPEDPYLKVLLALKLQDLGEHVEAEAHIEEALSSTSCQSYVIRYAAKYFRRKHRVDK 260

  Fly   734 ALAIYREALSSLPG---LPQQREILYQ--------------RIGDVLGRLQQWDEAERHHRAALE 781
            ||.:...||.:.|.   |..|:.:.|:              |..|.:..|.|  :|....:..|:
Mouse   261 ALHLLNRALQASPSSGYLHYQKGLCYKQQISQLRTSRNRQPRRQDNVQELAQ--QAIHEFQETLK 323

  Fly   782 LQPNQVAAHLSYGITLARNSSRASEAEMWFKRALK----LAPEQASVYHHYAEFLSLQSRHHESA 842
            |:|....|::......| ...:..|||..|::||.    :|..:..::..|..||....:..:.|
Mouse   324 LRPTFEMAYVCMAEVQA-EIHQYEEAERNFQKALNNKTLVAHIEQDIHLRYGRFLQFHKQSEDKA 387

  Fly   843 I-YHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRT 906
            | .:.:..::....:..........::.:|:|...:...::.:|          ||.:..|.|:.
Mouse   388 ITLYLKGLKVEEKSFAWRKLLTALEKVAERRVCQNVHLVESTSL----------LGLVYKLKGQE 442

  Fly   907 NHAAASYKAALRL 919
            .:|...|:.||||
Mouse   443 KNALFYYEKALRL 455

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Tmtc2	NP_608558.1	TMTC_DUF1736	270..343	CDD:462468
		TPR	597..852	CDD:440225	65/313 (21%)
		TPR repeat	602..630	CDD:276809	7/37 (19%)
		TPR repeat	635..665	CDD:276809	8/31 (26%)
		TPR repeat	670..694	CDD:276809	8/38 (21%)
		TPR repeat	715..743	CDD:276809	6/28 (21%)
		TPR repeat	748..782	CDD:276809	9/47 (19%)
		TPR	780..>933	CDD:440225	30/145 (21%)
		TPR repeat	787..816	CDD:276809	7/28 (25%)
		TPR repeat	822..850	CDD:276809	5/28 (18%)
		TPR repeat	855..885	CDD:276809	2/29 (7%)
		TPR repeat	890..918	CDD:276809	7/27 (26%)
Ifit1	NP_032357.2	TPR 1. /evidence=ECO:0000255	52..85		2/13 (15%)
		TPR repeat	55..86	CDD:276809	2/14 (14%)
		BepA	58..207	CDD:443813	32/140 (23%)
		TPR repeat	91..121	CDD:276809	6/34 (18%)
		TPR 2. /evidence=ECO:0000255	92..125		7/37 (19%)
		TPR repeat	136..166	CDD:276809	8/29 (28%)
		TPR 3. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	138..171		9/32 (28%)
		LapB	152..396	CDD:442196	52/246 (21%)
		TPR repeat	171..203	CDD:276809	8/31 (26%)
		TPR 4. /evidence=ECO:0000255	174..207		8/32 (25%)
		TPR repeat	208..236	CDD:276809	4/27 (15%)
		TPR 5. /evidence=ECO:0000255	209..241		4/31 (13%)
		TPR 6. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	242..275		8/32 (25%)
		TPR repeat	242..270	CDD:276809	6/27 (22%)
		TPR repeat	275..324	CDD:276809	9/50 (18%)
		TPR 7. /evidence=ECO:0000255	294..328		8/35 (23%)
		TPR 8. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	329..362		8/33 (24%)
		TPR repeat	329..356	CDD:276809	6/27 (22%)
		TPR 9. /evidence=ECO:0000255	367..401		5/33 (15%)
		TPR 10. /evidence=ECO:0000255|PROSITE-ProRule:PRU00339	426..459		11/40 (28%)