DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4341 and Ifit1

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_032357.2	Gene:	Ifit1 / 15957	MGIID:	99450	Length:	463	Species:	Mus musculus

Alignment Length:	403	Identity:	82/403 - (20%)
Similarity:	159/403 - (39%)	Gaps:	77/403 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly   576 SLRTLRRNADWRDEESLYRSAIAINPPKALGNL-------GSVLSSQGRYEEAKQVLQE---AIR 630
            :|::|:........|.|.:.::|     ..||.       ||:..:|...::.::|.:|   ..|
Mouse    71 ALQSLKEAEALIQSEQLSKRSLA-----TWGNCAWLHYHRGSLAEAQIYLDKVEKVCKEFSSPFR 130

  Fly   631 FRPNMADVHFNLG--ILHQNQQVYPAAVECFQRAIKFRPN--------LAVAY-LNLGISFIALG 684
            :|...|::....|  :|......|..|:.||.:|:|..|.        ..||| .:|..:||:|.
Mouse   131 YRLECAEMDCEEGWALLKCGGGNYKQAMACFAKALKVEPENPEYNTGYAVVAYRQDLDDNFISLE 195

  Fly   685 KRQQAIEI--------------LQ-AGSNLDGAAVRDRTAHDQARSSAYLQLGALYV-EQGKLQR 733
            ..::|:.:              || .|.:::..|..:......:..|..::..|.|. .:.::.:
Mouse   196 PLRKAVRLNPEDPYLKVLLALKLQDLGEHVEAEAHIEEALSSTSCQSYVIRYAAKYFRRKHRVDK 260

  Fly   734 ALAIYREALSSLPG---LPQQREILYQ--------------RIGDVLGRLQQWDEAERHHRAALE 781
            ||.:...||.:.|.   |..|:.:.|:              |..|.:..|.|  :|....:..|:
Mouse   261 ALHLLNRALQASPSSGYLHYQKGLCYKQQISQLRTSRNRQPRRQDNVQELAQ--QAIHEFQETLK 323

  Fly   782 LQPNQVAAHLSYGITLARNSSRASEAEMWFKRALK----LAPEQASVYHHYAEFLSLQSRHHESA 842
            |:|....|::......| ...:..|||..|::||.    :|..:..::..|..||....:..:.|
Mouse   324 LRPTFEMAYVCMAEVQA-EIHQYEEAERNFQKALNNKTLVAHIEQDIHLRYGRFLQFHKQSEDKA 387

  Fly   843 I-YHRRAAELAPNDYTLVVAAATAMRLLDRKVDAEMWYRKAVALRPGDAHAHTNLGAILHLLGRT 906
            | .:.:..::....:..........::.:|:|...:...::.:|          ||.:..|.|:.
Mouse   388 ITLYLKGLKVEEKSFAWRKLLTALEKVAERRVCQNVHLVESTSL----------LGLVYKLKGQE 442

  Fly   907 NHAAASYKAALRL 919
            .:|...|:.||||
Mouse   443 KNALFYYEKALRL 455

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453
		DUF1736	275..343	CDD:285594
		TPR_11	602..667	CDD:290150	18/76 (24%)
		TPR_1	602..634	CDD:278916	9/41 (22%)
		TPR repeat	602..630	CDD:276809	7/37 (19%)
		TPR repeat	635..665	CDD:276809	8/31 (26%)
		TPR_11	636..700	CDD:290150	21/89 (24%)
		TPR_1	636..668	CDD:278916	9/33 (27%)
		TPR repeat	670..694	CDD:276809	8/38 (21%)
		TPR_11	714..784	CDD:290150	18/87 (21%)
		TPR repeat	715..743	CDD:276809	6/28 (21%)
		TPR repeat	748..782	CDD:276809	9/47 (19%)
		TPR_11	755..819	CDD:290150	17/81 (21%)
		TPR repeat	787..816	CDD:276809	7/28 (25%)
		TPR_11	821..887	CDD:290150	8/66 (12%)
		TPR repeat	822..850	CDD:276809	5/28 (18%)
		TPR repeat	855..885	CDD:276809	2/29 (7%)
		TPR_11	<874..921	CDD:290150	11/46 (24%)
		TPR repeat	890..918	CDD:276809	7/27 (26%)
Ifit1	NP_032357.2	TPR 1	52..85		2/13 (15%)
		TPR_12	54..124	CDD:290160	11/57 (19%)
		TPR repeat	55..86	CDD:276809	2/14 (14%)
		TPR repeat	91..121	CDD:276809	6/34 (18%)
		TPR 2	92..126		8/38 (21%)
		TPR 3	136..171		10/34 (29%)
		TPR repeat	136..166	CDD:276809	8/29 (28%)
		TPR_16	145..208	CDD:290168	16/62 (26%)
		TPR repeat	171..203	CDD:276809	8/31 (26%)
		TPR 4	174..207		8/32 (25%)
		type_IV_pilW	<194..354	CDD:131573	31/162 (19%)
		TPR repeat	208..236	CDD:276809	4/27 (15%)
		TPR 5	209..241		4/31 (13%)
		TPR 6	242..275		8/32 (25%)
		TPR repeat	242..270	CDD:276809	6/27 (22%)
		Interaction with the 5'-triphosphate group of PPP-RNA. /evidence=ECO:0000250	247..253		2/5 (40%)
		TPR repeat	275..324	CDD:276809	9/50 (18%)
		TPR 7	294..328		8/35 (23%)
		TPR 8	329..362		8/33 (24%)
		TPR repeat	329..356	CDD:276809	6/27 (22%)
		TPR 9	367..401		5/33 (15%)
		TPR 10	426..459		11/40 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810