DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4341 and Bbs4

DIOPT Version :9

Sequence 1:	NP_608558.1	Gene:	CG4341 / 33276	FlyBaseID:	FBgn0028481	Length:	938	Species:	Drosophila melanogaster
Sequence 2:	NP_780534.1	Gene:	Bbs4 / 102774	MGIID:	2143311	Length:	520	Species:	Mus musculus

Alignment Length:	508	Identity:	98/508 - (19%)
Similarity:	166/508 - (32%)	Gaps:	160/508 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly   515 PFLPASNLLFYVGFVVAERLLYLPSVGFCLLVGYGVSKLMSCNQRTRNILLLSFSLLLAAMSLRT 579
            |.:...|.|.::.::..:               |...|.:...|......|..:::.:.|:..|
Mouse    30 PIVEKQNWLIHLHYIRKD---------------YEACKAVIKEQLQETQGLCEYAIYVQALIFR- 78

  Fly   580 LRRNADWRDEESL-YRSAIAINPPKALGNLGSVLSS---QGRYEEAKQVLQEAIRFRPNMADVHF 640
            |..|.    :||| .....|:..|:...||..|..|   .|:::.|.:|..||.:......::..
Mouse    79 LEGNI----QESLELFQTCAVLSPQCADNLKQVARSLFLLGKHKAATEVYNEAAKLNQKDWEICH 139

  Fly   641 NLGI---------------------------------LHQNQQVYPAAVECFQRAIKFRPNLAVA 672
            |||:                                 :|..|.....|:|.:::|::|.|.....
Mouse   140 NLGVCYTYLKQFNKAQDQLHSALQLNKHDLTYIMLGKIHLLQGDLDKAIEIYKKAVEFSPENTEL 204

  Fly   673 YLNLGISFIALGKRQQAIEILQAGSNLDGAAVRDRTAHDQARSSAYLQLGALYVEQGKLQRALAI 737
            ...||:.::.||..|:|.|.|       |.|:    .:|.|...|.|..|::....|....||..
Mouse   205 LTTLGLLYLQLGVYQKAFEHL-------GNAL----TYDPANYKAILAAGSMMQTHGDFDVALTK 258

  Fly   738 YREALSSLP---------GL----------------------PQQREILYQRIGDVLGRLQQWDE 771
            ||....::|         |:                      |...:||| .:|.|...:||:..
Mouse   259 YRVVACAIPESPPLWNNIGMCFFGKKKYVAAISCLKRANYLAPFDWKILY-NLGLVHLTMQQYAS 322

  Fly   772 AERHHRAALELQPNQVAAHLSYGITLARNSSRASEAEMWFKRALKLAPEQASVYHHYAEFLSLQS 836
            |.....||:..||.....::...:.|. |......|...:..|::|......|..:||..|..|.
Mouse   323 AFHFLSAAINFQPKMGELYMLLAVALT-NLEDIENARRAYVEAVRLDKCNPLVNLNYAVLLYNQG 386

  Fly   837 RHHESAIYHRRAAELAPNDYTLVVAAATAMRLLDRKVD--------------AEMWYRKAVALRP 887
            ....:...::.                     :::||:              .||..:...||:.
Mouse   387 EKKSALAQYQE---------------------MEKKVNFLKDNSPLEFDSEMVEMAQKLGAALQV 430

  Fly   888 GDAHAHTN-----------------------LGAILHLLGRTNHAAASYKAAL 917
            |:|...|.                       ||:| ..||:...:||:|:..|
Mouse   431 GEALVWTKPVKDPKTKHRTNSGSKSATLQQPLGSI-QALGQAMSSAAAYRKIL 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4341	NP_608558.1	PMT_2	112..>232	CDD:304453
		DUF1736	275..343	CDD:285594
		TPR_11	602..667	CDD:290150	19/100 (19%)
		TPR_1	602..634	CDD:278916	10/34 (29%)
		TPR repeat	602..630	CDD:276809	10/30 (33%)
		TPR repeat	635..665	CDD:276809	8/62 (13%)
		TPR_11	636..700	CDD:290150	18/96 (19%)
		TPR_1	636..668	CDD:278916	9/64 (14%)
		TPR repeat	670..694	CDD:276809	7/23 (30%)
		TPR_11	714..784	CDD:290150	21/100 (21%)
		TPR repeat	715..743	CDD:276809	8/27 (30%)
		TPR repeat	748..782	CDD:276809	11/55 (20%)
		TPR_11	755..819	CDD:290150	16/63 (25%)
		TPR repeat	787..816	CDD:276809	4/28 (14%)
		TPR_11	821..887	CDD:290150	11/79 (14%)
		TPR repeat	822..850	CDD:276809	5/27 (19%)
		TPR repeat	855..885	CDD:276809	4/43 (9%)
		TPR_11	<874..921	CDD:290150	16/81 (20%)
		TPR repeat	890..918	CDD:276809	11/51 (22%)
Bbs4	NP_780534.1	Required for localization to centrosomes. /evidence=ECO:0000250	1..66		6/50 (12%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..26
		TPR 1	67..100		9/37 (24%)
		TPR repeat	68..95	CDD:276809	7/31 (23%)
		Interaction with PCM1. /evidence=ECO:0000250	101..337		54/247 (22%)
		TPR_11	101..166	CDD:290150	12/64 (19%)
		TPR repeat	101..129	CDD:276809	9/27 (33%)
		TPR repeat	134..164	CDD:276809	3/29 (10%)
		TPR_11	136..199	CDD:290150	9/62 (15%)
		TPR_11	169..233	CDD:290150	17/74 (23%)
		TPR repeat	169..196	CDD:276809	5/26 (19%)
		TPR	170..201	CDD:197478	7/30 (23%)
		TPR repeat	202..229	CDD:276809	9/33 (27%)
		TPR repeat	236..264	CDD:276809	8/27 (30%)
		TPR_11	237..301	CDD:290150	10/63 (16%)
		TPR repeat	270..298	CDD:276809	1/27 (4%)
		TPR_11	272..335	CDD:290150	12/63 (19%)
		TPR repeat	303..333	CDD:276809	10/30 (33%)
		TPR_11	305..369	CDD:290150	17/65 (26%)
		Required for localization to centrosomes. /evidence=ECO:0000250	338..520		28/168 (17%)
		TPR repeat	338..366	CDD:276809	4/28 (14%)
		TPR_16	342..400	CDD:290168	10/79 (13%)
		TPR repeat	372..397	CDD:276809	5/24 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	488..520
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1124
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900